Cognitive effects of modafinil in patients with multiple sclerosis: A clinical trial.

Abstract

Findings indicate that 200 mg of modafinil has the potential to improve working memory in persons with MS. These findings suggest that modafinil may enhance aspects of cognition in persons with MS and may be an effective adjunct to clinical rehabilitation interventions.

Fatigue in multiple sclerosis – Insights into evaluation and management

“…FSS scores exhibited only a trend toward significant decrease, while the other scales did not show any difference [134]. Moreover, a crossover placebo-controlled study was published in 2016; it aimed to assess the impact of modafinil on fatigue and cognition in persons with MS [65]. Although the results plead for a potential role of the medication on memory performance, no effect was found on fatigue.…”

Combinatorial Targeting of Distributed Forebrain Networks Reverses Noise Hypersensitivity in a Model of Autism Spectrum Disorder

“…To correct PFC dysfunction, we considered a newly discovered role of the mediodorsal (MD) thalamus in enhancing local functional PFC connectivity (Bolkan et al, 2017;Halassa and Kastner, 2017;Halassa and Sherman, 2019;Nakajima and Halassa, 2017;Rikhye et al, 2018aRikhye et al, , 2018bHalassa, 2018), asking whether pharmacological agents known to activate the MD might enhance PFC functional connectivity. We found that modafinil was a prime candidate; it is a known cognitive enhancer with clinical efficacy in treating cognitive symptoms across a variety of disorders (Ford-Johnson et al, 2016;Wang et al, 2017) and improving psychomotor vigilance (Czeisler et al, 2005). Unlike classical stimulants, modafinil leads to improvement on a broad range of cognitive control tasks, particularly in attention deficit hyperactivity disorder (Minzenberg and Carter, 2008;Turner et al, 2004), a comorbidity often seen in Ptchd1 deletion patients (Chaudhry et al, 2015).…”

Practical Evidence-Based Recommendations for Patients with Multiple Sclerosis Who Want to Have Children

“…Modafinil is another drug used off-label for treatment of fatigue and cognitive dysfunction in MS [ 62 , 63 ]. The effect of modafinil in MS, if any, is small and is poorly studied.…”