Cognitive Effects of Exogenous Melatonin Administration in Elderly Persons: A Pilot Study

Peck, Joel S.; LeGoff, Daniel B.; Ahmed, D. Iqbal; Goebert, Deborah

doi:10.1176/appi.ajgp.12.4.432

Cited by 33 publications

(18 citation statements)

References 13 publications

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“…The possibility that these are causally related is supported by several intervention studies demonstrating that improving the consistency of sleepwake cycles with melatonin subsequently enhanced cognitive performance in older adults with and without cognitive impairment (Cardinali et al, 2012: Jeane-Louis et al, 1998Peck et al, 2004). This is important because previous work has shown that individuals with more variable CARs are at a higher risk of developing neurocognitive disorders.…”

Section: Discussionmentioning

confidence: 97%

Hippocampal activity mediates the relationship between circadian activity rhythms and memory in older adults

2015

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Section: Discussionmentioning

confidence: 97%

Hippocampal activity mediates the relationship between circadian activity rhythms and memory in older adults

2015

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“…Thus increased levels of Sgk expression in the CNS produced following melatonin supplementation may result in similar beneficial effects. Such effects may also contribute to improved learning in older humans observed with nightly administration of 1 mg of melatonin (Peck et al, 2004).…”

Section: Genes Altered By Melatonin But Not Changed With Agementioning

confidence: 99%

Effects of melatonin and age on gene expression in mouse CNS using microarray analysis

Sharman

Bondy

Sharman

et al. 2007

Neurochemistry International

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The expression levels of a number of genes associated with inflammation and immune function change with advancing age. Melatonin modulates gene expression levels of several of these genes. Therefore the declining levels of melatonin associated with age may play a role in the physiological effects of aging. We used oligonucleotide microarrays to measure age-related changes in mRNA expression in the murine CNS, and to study the effect of prolonged administration of dietary melatonin upon these changes. CB6F1 male mice were fed 40ppm melatonin for 2.1 months prior to sacrifice at age 26.5 months, and compared with both age-matched controls and young, 4.5-monthold untreated controls. Total RNA was extracted from whole brain (excluding cerebellum and brain stem) and individual samples were hybridized to Affymetrix Mouse 430-2.0 arrays. The expression of a substantial number of genes was modulated by melatonin treatment and changes in selected genes were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). A subset of these genes did not change with age. Conversely, some genes modulated by age were also modulated by melatonin treatment. In general melatonin treatment drove the expression levels of these genes closer to the expression levels detected in the younger animals. Notably, the abundance of lipocalin 2 (Lcn2) mRNA increased with age and was decreased in old animals treated with melatonin. Lcn2 is a member of the acute phase response family of proteins and its mRNA levels in the brain increase in response to inflammation. Many of the genes with expression reduced by melatonin are involved in inflammation and the immune system. This suggests that melatonin treatment may influence the inflammatory responses of old animals, driving them to resemble more closely those occurring in young animals.

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“…Several studies reported alterations of alertness and performances by acute melatonin when administered during daytime (Atkinson et al, 2005;Cajochen et al, 1996;Dollins et al, 1993;Graw et al, 2001;Lieberman et al, 1984;Neville and McNaughton, 1986;Rogers et al, 1998) but not when administered during late afternoon or at bedtime in young and middle-aged (20-57 years) healthy volunteers (Paul et al, 2003;Stone et al, 2000;Suhner et al, 1998;Wynn and Arendt, 1988). Furthermore, melatonin administered nightly for 4 weeks improved certain aspects of cognition in healthy elderly subjects (Peck et al, 2004). Fainstein et al (1997) noted that melatonin at bedtime augmented the quality of alertness that is impaired with hypnotics (benzodiazepines).…”

Section: Introductionmentioning

confidence: 99%

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Otmani

Demazieres

Staner

et al. 2008

Human Psychopharmacology

116

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Cognitive Effects of Exogenous Melatonin Administration in Elderly Persons: A Pilot Study

Cited by 33 publications

References 13 publications

Hippocampal activity mediates the relationship between circadian activity rhythms and memory in older adults

Hippocampal activity mediates the relationship between circadian activity rhythms and memory in older adults

Effects of melatonin and age on gene expression in mouse CNS using microarray analysis

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

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