Cognitive Effects Of Anti-Epileptic Drugs In Nigerians With Epilepsy

Ogunrin, Olubunmi; Adamolekun, B; Oguniiyi, A

doi:10.4314/ajns.v24i1.7563

Cited by 7 publications

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“…The cognitive performance was however worse in PWE on phenytoin when compared with those on carbamazepine. This pattern has been consistently noted by other authors (8,23,29,31). The duration of therapy affected all the cognitive tasks assessed portraying the contributory role of prolonged administration of AED on cognitive functioning of PWE.…”

Section: Discussionsupporting

confidence: 83%

Seizure variables and cognitive performance in patients with epilepsy

Sunmonu¹,

Ogunrin²,

Komolafe³

et al. 2010

African Journal of Neurological Sciences

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Background and Purpose Epilepsy is highly prevalent in developing African countries with significant morbidity, social stigmatization, poor quality of life and preventable mortality. There are scanty reports on the contributions of seizure variables like seizure types, frequency of seizures, duration of epilepsy, age at onset and anti-epileptic drugs to cognitive disturbances in Nigerian Africans. This study assessed the effects of seizure variables on the cognitive performances of patients with epilepsy. Methods The cognitive functions of 41 patients with epilepsy and 41 controls were assessed with a computerassisted cognitive test battery, Iron Psychology (acronym-FePsy) using the simple and complex reaction time tasks for mental speed, recognition memory test (RMT) for memory and continuous performance test for attention. Results The cognitive performances of the patients using complex reaction time and the recognition memory tasks were worse than those of the controls (p<0.05). The duration of treatment with anti-epileptic drugs negatively affected all cognitive domains assessed. The seizure frequency, duration of epilepsy and the use of phenytoin were associated with psychomotor retardation and impaired memory. Conclusions The seizure variables negatively affected cognitive performances of Nigerian patients with epilepsy. Cognitive assessment is recommended as part of regular evaluation of patients with epilepsy.

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Section: Discussionsupporting

confidence: 83%

Seizure variables and cognitive performance in patients with epilepsy

Sunmonu¹,

Ogunrin²,

Komolafe³

et al. 2010

African Journal of Neurological Sciences

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“…The high rates of memory impairment are similar to reports by Suresh et al and Eddy et al [25,30]. Whereas a study carried out in the south-south region of Nigeria did not report significant memory impairment in patients on AEDs [31].…”

Section: Discussionsupporting

confidence: 75%

Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications

et al. 2017

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Abstract.Background and aims: Antiepileptic drugs do cause adverse effects, affecting quality of life, adherence and seizures. Consequently, need to study this among Nigerian patients. Methods: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors. Results: 54 patients (64.3 %) reported no adverse effects, while 30 did. Commonest adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects. Conclusions: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women. IntroductionEpilepsy is a chronic neurological condition that affects between 65 to 70million people worldwide [1,2], with drug therapy the mainstay of the treatment. It is estimated that 70% of patients will respond to the medicines prescribed whilst the remainder will need surgery and other forms of therapy to achieve seizure control [2,3,4].

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“…It may be useful in focus localization and prognosticating the severity of brain involvement. Neuropsychological assessment is advised before the commencement of antiepileptic drug 16,17 and if surgery is contemplated.…”

Section: Discussionmentioning

confidence: 99%

Profile of Post-traumatic Epilepsy in Benin City, Nigeria

Ogunrin¹,

Adeyekun²

2011

West African Journal of Medicine

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BACKGROUND: Post traumatic epilepsy is recurrent chronic seizures occurring after four weeks following brain injury. It commonly occurs after road traffic accidents thus making it a preventable cause of chronic seizures. The prevalence and pattern of this disorder is not known among Nigerian patients with epilepsy. OBJECTIVE: This study aimed at determining the prevalence of and predisposing type of head injury to developing post traumatic epilepsy. METHODS: We studied 244 consecutive patients with epilepsy attending the neurology clinic of a tertiary health facility in an urban Nigerian city by analyzing the details of their demographic and clinical data obtained with the aid of a structured questionnaire and from the Epilepsy Registry of a Neurology Unit between January and December 2006. RESULTS: Thirty-eight patients with a mean age of 38.6 ± 7.3 years (age range 15-75 years) had posttraumatic epilepsy comprising 15.57% of all cases of epilepsy. Thirty-three (86.8%) had closed head injury. Thirty-two (84.2%) of the patients had positive history of loss of consciousness. Twentytwo patients (57.9%) sustained head injury from motor vehicle accidents. Majority of the patients had secondarily generalized seizures (73.7% of the cases). Twenty-seven (71.4%) of the 38 patients had seizure onset in the first year after brain injury. Depressed skull fracture (19/38; 50%) was the most common abnormal CT finding. CONCLUSION: Post traumatic epilepsy contributes significantly to the number of patients with epilepsy presenting to our neurology services. There is need to educate people on the usefulness of seat-belts and helmets while driving. WAJM 2010; 29(3): 153-157.

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Cognitive Effects Of Anti-Epileptic Drugs In Nigerians With Epilepsy

Cited by 7 publications

References 0 publications

Seizure variables and cognitive performance in patients with epilepsy

Seizure variables and cognitive performance in patients with epilepsy

Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications

Profile of Post-traumatic Epilepsy in Benin City, Nigeria

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