Cognitive Dysfunction in Type 1 Diabetes Mellitus

Shalimova, Anna; Graff, Beata; Gąsecki, Dariusz; Wolf, Jacek; Sabisz, Agnieszka; Szurowska, Edyta; Jodzio, Krzysztof; Narkiewicz, Krzysztof

doi:10.1210/jc.2018-01315

Cited by 100 publications

(63 citation statements)

References 96 publications

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“…Importantly, values > 180 mg/dL (10 mmol/L) were as rare as values < 54 mg/ dL (3.0 mmol/L); it is curious why so many diabetologists, certified diabetes educators, and individuals with diabetes so lightheartedly accept values > 180 mg/dL (10 mmol/L) in day-to-day diabetes management. Such an attitude may well need a more thorough consideration, particularly in the view of recent data strongly linking hyperglycemia to vascular dementia (6).…”

Section: Commentmentioning

confidence: 99%

Continuous and Intermittent Glucose Monitoring in 2019

Battelino

Dovč

Bode

2020

Diabetes Technology & Therapeutics

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Section: Commentmentioning

confidence: 99%

Continuous and Intermittent Glucose Monitoring in 2019

Battelino

Dovč

Bode

2020

Diabetes Technology & Therapeutics

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“…Clinical studies from both adult and pediatric populations with diabetes mellitus offer evidence that high blood glucose levels have adverse effects on the brain. Type 2 diabetes (T2D) is a risk factor for the development of dementia later in life [10,11]. Children with hyperglycemia due to early onset type 1 diabetes (T1D), have structural and functional hippocampal deficits [12].…”

Section: Clinical Studiesmentioning

confidence: 99%

Hyperglycemia-Induced Brain Injury in Preterm Infants

Satrom¹,

Gisslen²,

Rao³

2019

obm neurobiol

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Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white matter content, abnormal synaptogenesis, microgliosis, and functional deficits in the absence of intraventricular hemorrhage. Data suggest that oxidative stress, inflammation, and abnormal substrate metabolism are responsible for these effects.

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“…Previous studies showed that T1DM leads to impairments in various cognitive domains in children, including intelligence quotient (IQ), attention, memory, processing speed, motor, visuospatial, and executive function (4). These impairments may begin in the early stage of disease and gradually progress with age (5,6), which will ultimately affect the quality of life and increase the burden on families and society. Therefore, a better understanding of the effects of T1DM and its metabolic disorders on children's brain is critical for promoting evidence-based pediatric management programs and positive interventions.…”

Section: Introductionmentioning

confidence: 99%

Disrupted Regional Cerebral Blood Flow in Children With Newly-Diagnosed Type 1 Diabetes Mellitus: An Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Study

et al. 2020

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Object: Diabetes is associated with cerebral vascular dysfunction and increased vascular cognitive impairment. The objective of this study was to use arterial spin labeling (ASL) perfusion-weighted magnetic resonance imaging to investigate whether cerebral perfusion was changed in newly-diagnosed children with type 1 diabetes mellitus (T1DM) and the possible relationship between aberrant cerebral blood flow (CBF) with cognitive as well as clinical variables. Methods: Between January 2017 and February 2018, 34 children with newly-diagnosed T1DM and 34 age, gender, and education-matched healthy controls were included. Three dimensional pseudo-continuous ASL perfusion MRI was used to evaluate CBF. A conventional T2WI sequence was added to exclude intracranial disease. Regions with CBF differences between T1DM children and the controls were detected via voxel-wise comparisons in REST software. Associations among the result of neuropsychological test, clinical variables, and CBF values of different brains were investigated by using partial correlation analysis. Results: Compared with the controls, T1DM children show decreased CBF in the left calcarine and postcentral gyrus, and right precentral gyrus. The perfusion in the postcentral gyrus was positively correlated with IQ performance. No significant correlations were found between CBF and HbA1c, blood glucose level before imaging and IQ in other brain regions in T1DM children. Conclusion: There is an abnormal cerebral perfusion in children with newly diagnosed T1DM. The visual and sensorimotor areas are brain areas where perfusion is prone to change at the beginning of T1DM. Our study provided clues for cerebral pathophysiological changes in the initial stage of T1DM.

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Cognitive Dysfunction in Type 1 Diabetes Mellitus

Cited by 100 publications

References 96 publications

Continuous and Intermittent Glucose Monitoring in 2019

Continuous and Intermittent Glucose Monitoring in 2019

Hyperglycemia-Induced Brain Injury in Preterm Infants

Disrupted Regional Cerebral Blood Flow in Children With Newly-Diagnosed Type 1 Diabetes Mellitus: An Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Study

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