Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective

Besson, Morgane; Forget, Benoît

doi:10.3389/fpsyt.2016.00160

Cited by 42 publications

(31 citation statements)

References 393 publications

(386 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of nicotine on mood and cognition might be dependent on different factors such as neurobiological/genetic background of the subjects. These leading to the substantial heterogeneity in the underlying causes of cognitive impairments in passive-smokers (Besson and Forget, 2016;Hall et al, 2015). Also the causal relationships may be due to the genetic relationships to the parents, not due to their smoking.…”

Section: Discussionmentioning

confidence: 99%

Passive smoking is associated with cognitive and emotional impairment in adolescent girls

Khorasanchi

Bahrami

Avan

et al. 2019

The Journal of General Psychology

View full text Add to dashboard Cite

It is well established that smoking is associated with impaired mental health and sleep problems. However the possible effects of passive smoking on cognitive and emotional characteristics have not previously been evaluated in adolescents. We investigated the association between passive smoking and cognitive and emotional function, and sleep patterns in 940 adolescent girls. The girls were divided into 2 groups [305 exposed subjects and 635 non-exposed subjects (the controls)]. The passive smokers had a significantly lower cognitive function and higher depression, aggression, and insomnia scores compared to the control group (P <0.05). No significant difference was detected with respect to daytime sleepiness and sleep apnea. Logistic regression analyses showed that the passive smokers were more likely than the controls to have cognitive impairments, depressive mood, aggressive behavior and insomnia. Adolescents passive smokers had significant differences in their cognitive abilities and emotional function.

show abstract

Section: Discussionmentioning

confidence: 99%

Passive smoking is associated with cognitive and emotional impairment in adolescent girls

Khorasanchi

Bahrami

Avan

et al. 2019

The Journal of General Psychology

View full text Add to dashboard Cite

show abstract

“…It was suggested that downregulation of the dopaminergic system in the VTA, NAc and central nucleus of the amygdala (CeA), together with upregulation of corticotropin‐releasing factor (CRF) and norepinephrine systems in the CeA and VTA, underlie excessive nicotine intake, driven by negative reinforcement . For example, cocaine increases DA and 5‐HT release, but decreases in dopaminergic and serotonergic transmission were observed in the ventral striatum during cocaine withdrawal in rats .…”

Section: Clinical and Neurobiological Similarities Between Addiction mentioning

confidence: 99%

Addiction and the itch‐scratch cycle. What do they have in common?

Ishiuji

2019

Experimental Dermatology

View full text Add to dashboard Cite

Itch is a multidimensional experience involving various brain regions associated with sensory perception and emotion, as well as an urge to scratch employing the motor system. Scratch temporarily relieves itch sensation in healthy subjects. However, in patients with chronic itch, rather than inhibit, scratch may aggravate itch. Patients with chronic itch, such as those with atopic dermatitis, experience severe itch and a strong desire to scratch. This urge to scratch is the driving force underlying the formation of the itch‐scratch‐cycle, an addictive and vicious cycle in chronic itch patients. This vicious itch‐scratch behaviour and various types of addiction (henceforth, including recreational drug use) were shown to share common sensory mechanisms. Abnormalities have been observed in central neural circuits, including the reward, motivation/drive, control and learning/memory circuits, as well as other brain systems. Reward systems, including the ventral tegmental area (VTA), nucleus accumbens (NAc) and striatum, are important for brain processing of both addiction and itch. In addition to reward, addicted individuals can experience severe disruptions in motor control, cognitive awareness, executive function, learning/memory and even emotional functions. Findings showing that addiction and itch share a common neurobiological foundation could have important mechanistic and therapeutic implications. Here we propose that similar neuroadaptations exist in addiction and chronic itch patients.

show abstract

“…Because these psychiatric disorders are associated with various cognitive impairments, including deficits in attention, working memory, and response inhibition functions [ 17 , 18 ], the cognitive enhancing effects of nicotine may be especially important determinants of the initation and maintenance of smoking in this comorbid population. Growing evidence suggest that cognitive enhancing effects of nicotine may also contribute to the difficulty in quitting smoking, especially in individuals with psychiatric disorders [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Effects of Nicotine: Recent Progress

2018

View full text Add to dashboard Cite

BackgroundCigarette smoking is the main cause of preventable death in developed countries. While the direct positive behavioral reinforcing effect of nicotine has historically been considered the primary mechanism driving the development of TUD, accumulating contemporary research suggests that the cognitive-enhancing effects of nicotine may also significantly contribute to the initiation and maintenance of TUD, especially in individuals with pre-existing cognitive deficits.MethodsWe provide a selective overview of recent advances in understanding nicotine’s effects on cognitive function, a discussion of the role of cognitive function in vulnerability to TUD, followed by an overview of the neurobiological mechanisms underlying the cognitive effects of nicotine.ResultsPreclinical models and human studies have demonstrated that nicotine has cognitive-enhancing effects. Attention, working memory, fine motor skills and episodic memory functions are particularly sensitive to nicotine’s effects. Recent studies have demonstrated that the α4, β2, and α7 subunits of the nicotinic acetylcholine receptor (nAChR) participate in the cognitive-enhancing effects of nicotine. Imaging studies have been instrumental in identifying brain regions where nicotine is active, and research on the dynamics of large-scale networks after activation by, or withdrawal from, nicotine hold promise for improved understanding of the complex actions of nicotine on human cognition.ConclusionBecause poor cognitive performance at baseline predicts relapse among smokers who are attempting to quit smoking, studies examining the potential efficacy of cognitive-enhancement as strategy for the treatment of TUD may lead to the development of more efficacious interventions.

show abstract

Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective

Cited by 42 publications

References 393 publications

Passive smoking is associated with cognitive and emotional impairment in adolescent girls

Passive smoking is associated with cognitive and emotional impairment in adolescent girls

Addiction and the itch‐scratch cycle. What do they have in common?

Cognitive Effects of Nicotine: Recent Progress

Contact Info

Product

Resources

About