Cognitive disruptions in stress-related psychiatric disorders: A role for corticotropin releasing factor (CRF)

Bangasser, Debra A.; Kawasumi, Yushi

doi:10.1016/j.yhbeh.2015.04.003

Cited by 37 publications

(21 citation statements)

References 247 publications

(326 reference statements)

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“…The CRH/CRHR1 system is considered fundamental for the regulation of stress and anxiety in both experimental animals and humans (Altemus et al, 2014; Bangasser and Kawasumi, 2015). Genetic studies have established that loss of Crhr1 in glutamatergic cells in the cerebral cortex is anxiolytic (Refojo et al, 2011), and that CRH dysfunction can contribute to human anxiety related disorders (Weber et al, 2015; Smoller, 2016).…”

Section: Resultsmentioning

confidence: 99%

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

Nakajima

Ibañez–Tallon

et al. 2016

Cell

191

174

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SUMMARY The frequency of human social and emotional disorders varies significantly between males and females. We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female sociosexual behavior. Here we show that in male mice OxtrINs regulate anxiety-related behaviors. We demonstrate that corticotropin releasing hormone binding protein (CRHBP), an antagonist of the stress hormone CRH, is specifically expressed in OxtrINs. Production of CRHBP blocks the CRH-induced potentiation of postsynaptic layer 2/3 pyramidal cell activity of male but not female mice, thus producing an anxiolytic effect. Our data identify OxtrINs as critical for modulation of social and emotional behaviors in both females and males, and reveal a molecular mechanism that acts on local mPFC circuits to coordinate responses to OXT and CRH. They suggest that additional studies of the impact of the OXT/OXTR and CRHBP/CRH pathways in males and females will be important in development of gender specific therapies.

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Section: Resultsmentioning

confidence: 99%

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

Nakajima

Ibañez–Tallon

et al. 2016

Cell

191

174

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“…Although most of the research has focused on males (reviewed in [57]), our laboratory assessed in both sexes the effect of central CRF administration on attention. We specifically tested sustained attention, which is the ability to continuously monitor situations for intermittent and unpredictable events [60].…”

Section: Sex Differences In Crf-mediated Responses To Stressmentioning

confidence: 99%

Sex differences in stress responses: a critical role for corticotropin-releasing factor

2018

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Rates of post-traumatic stress disorder, panic disorder, and major depression are higher in women than in men. Another shared feature of these disorders is that dysregulation of the stress neuropeptide, corticotropin-releasing factor (CRF), is thought to contribute to their pathophysiology. Therefore, sex differences in responses to CRF could contribute to this sex bias in disease prevalence. Here, we review emerging data from non-human animal models that reveal extensive sex differences in CRF functions ranging from its presynaptic regulation to its postsynaptic efficacy. Specifically, detailed are sex differences in the regulation of CRF-containing neurons and the amount of CRF that they produce. We also describe sex differences in CRF receptor expression, distribution, trafficking, and signaling. Finally, we highlight sex differences in the processes that mitigate the effects of CRF. In most cases, the identified sex differences can lead to increased stress sensitivity in females. Thus, the relevance of these differences for the increased risk of depression and anxiety disorders in women compared to men is also discussed.

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“…In humans, enhanced CRF levels found in the CSF of PTSD patients have indicated a link between increased CRF concentrations and disrupted fear extinction observed in PTSD and anxiety disorders (Bangasser and Kawasumi, 2015; Gafford and Ressler, 2015). In rats, administration of CRF into the lateral amygdala before fear recall testing in formerly fear-conditioned animals induced enhanced freezing responses to the conditioned stimulus (Isogawa et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Involvement of CRFR₁in the Basolateral Amygdala in the Immediate Fear Extinction Deficit

Hollis¹,

Sevelinges²,

Grosse³

et al. 2016

eNeuro

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Several animal and clinical studies have highlighted the ineffectiveness of fear extinction sessions delivered shortly after trauma exposure. This phenomenon, termed the immediate extinction deficit, refers to situations in which extinction programs applied shortly after fear conditioning may result in the reduction of fear behaviors (in rodents, frequently measured as freezing responses to the conditioned cue) during extinction training, but failure to consolidate this reduction in the long term. The molecular mechanisms driving this immediate extinction resistance remain unclear. Here we present evidence for the involvement of the corticotropin releasing factor (CRF) system in the basolateral amygdala (BLA) in male Wistar rats. Intra-BLA microinfusion of the CRFR1 antagonist NBI30775 enhances extinction recall, whereas administration of the CRF agonist CRF6–33 before delayed extinction disrupts recall of extinction. We link the immediate fear extinction deficit with dephosphorylation of GluA1 glutamate receptors at Ser845 and enhanced activity of the protein phosphatase calcineurin in the BLA. Their reversal after treatment with the CRFR1 antagonist indicates their dependence on CRFR1 actions. These findings can have important implications for the improvement of therapeutic approaches to trauma, as well as furthering our understanding of the neurobiological mechanisms underlying fear-related disorders.

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Cognitive disruptions in stress-related psychiatric disorders: A role for corticotropin releasing factor (CRF)

Cited by 37 publications

References 247 publications

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

Sex differences in stress responses: a critical role for corticotropin-releasing factor

Involvement of CRFR₁in the Basolateral Amygdala in the Immediate Fear Extinction Deficit

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Cognitive disruptions in stress-related psychiatric disorders: A role for corticotropin releasing factor (CRF)

Cited by 37 publications

References 247 publications

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

Sex differences in stress responses: a critical role for corticotropin-releasing factor

Involvement of CRFR1in the Basolateral Amygdala in the Immediate Fear Extinction Deficit

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Involvement of CRFR₁in the Basolateral Amygdala in the Immediate Fear Extinction Deficit