Cognitive differences among depressed and non‐depressed MCI participants: a project FRONTIER study

Johnson, Leigh A.; Mauer, Cortney B.; Jahn, Danielle R.; Song, Michael; Wyshywaniuk, Lauren; Hall, James; Balldin, Valerie Hobson; O’Bryant, Sid

doi:10.1002/gps.3835

Cited by 39 publications

(35 citation statements)

References 29 publications

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“…Johnson et al [37] reported a greater prevalence of depression as assessed with the Geriatric Depression Scale (GDS-30) among non-amnestic than among amnestic MCI community-based patients (depression: 51.0 vs. 33.0%), as did Hidaka et al [38] in a study of amnestic compared with non-amnestic MCI community-based individuals (depression: 35.9 vs. 23.5%). However, the statistical significance of these differences was not indicated [37,38]. …”

Section: Discussionmentioning

confidence: 97%

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Kosteniuk

Morgan

O’Connell³

et al. 2014

Dement Geriatr Cogn Disord Extra

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Background/Aims: To estimate the prevalence, severity, and covariates of depressive symptoms in rural memory clinic patients diagnosed with either mild cognitive impairment (MCI) or dementia. Methods: In a cross-sectional study of 216 rural individuals who attended an interdisciplinary memory clinic between March 2004 and July 2012, 51 patients were diagnosed with MCI and 165 with either dementia due to Alzheimer's disease (AD) or non-AD dementia. The Center for Epidemiologic Studies of Depression Scale (CES-D) was used to estimate the severity and prevalence of clinically elevated depressive symptomatology. Results: The prevalence of elevated depressive symptoms was 51.0% in the MCI patients and 30.9% in the dementia patients. Depressive symptoms were more severe in the MCI patients than in the dementia patients. Elevated depressive symptoms were statistically associated with younger age for the MCI group, with lower self-rated memory for the dementia group, and with increased alcohol use and lower quality of life ratings for all patients. In the logistic regression models, elevated depressive symptoms remained negatively associated with self-rated memory and quality of life for the patients with dementia, but significant bivariate associations did not persist in the MCI group. Conclusions: The high prevalence and severity of depressive symptoms among rural memory clinic patients diagnosed with either MCI or dementia warrant continued investigation.

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Section: Discussionmentioning

confidence: 97%

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Kosteniuk

Morgan

O’Connell³

et al. 2014

Dement Geriatr Cogn Disord Extra

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“…The distinctive pattern of cognitive impairment caused by other conditions such as depression requires the use of elaborate scales such as the Cambridge Cognitive Examination, [93][94][95] the Alzheimer's Disease Assessment Scale 96,97 or the Repeatable Battery for the Assessment of Neuropsychological Status. 98,99 Current pen-and-paper tests screening instruments for MCI cannot do this.…”

Section: Applicability Of Findings To the Review Questionmentioning

confidence: 99%

Automated tests for diagnosing and monitoring cognitive impairment: a diagnostic accuracy review

Aslam

Bates

Dündar

et al. 2016

Health Technol Assess

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BackgroundCognitive impairment is a growing public health concern, and is one of the most distinctive characteristics of all dementias. The timely recognition of dementia syndromes can be beneficial, as some causes of dementia are treatable and are fully or partially reversible. Several automated cognitive assessment tools for assessing mild cognitive impairment (MCI) and early dementia are now available. Proponents of these tests cite as benefits the tests’ repeatability and robustness and the saving of clinicians’ time. However, the use of these tools to diagnose and/or monitor progressive cognitive impairment or response to treatment has not yet been evaluated.ObjectivesThe aim of this review was to determine whether or not automated computerised tests could accurately identify patients with progressive cognitive impairment in MCI and dementia and, if so, to investigate their role in monitoring disease progression and/or response to treatment.Data sourcesFive electronic databases (MEDLINE, EMBASE, The Cochrane Library, ISI Web of Science and PsycINFO), plus ProQuest, were searched from 2005 to August 2015. The bibliographies of retrieved citations were also examined. Trial and research registers were searched for ongoing studies and reviews. A second search was run to identify individual test costs and acquisition costs for the various tools identified in the review.Review methodsTwo reviewers independently screened all titles and abstracts to identify potentially relevant studies for inclusion in the review. Full-text copies were assessed independently by two reviewers. Data were extracted and assessed for risk of bias by one reviewer and independently checked for accuracy by a second. The results of the data extraction and quality assessment for each study are presented in structured tables and as a narrative summary.ResultsThe electronic searching of databases, including ProQuest, resulted in 13,542 unique citations. The titles and abstracts of these were screened and 399 articles were shortlisted for full-text assessment. Sixteen studies were included in the diagnostic accuracy review. No studies were eligible for inclusion in the review of tools for monitoring progressive disease. Eleven automated computerised tests were assessed in the 16 included studies. The overall quality of the studies was good; however, the wide range of tests assessed and the non-standardised reporting of diagnostic accuracy outcomes meant that meaningful synthesis or statistical analysis was not possible.LimitationsThe main limitation of this review is the substantial heterogeneity of the tests assessed in the included studies. As a result, no meta-analyses could be undertaken.ConclusionThe quantity of information available is insufficient to be able to make recommendations on the clinical use of the computerised tests for diagnosing and monitoring MCI and early dementia progression. The value of these tests also depends on the costs of acquisition, training, administration and scoring.Future workResearch is required to establish stable cut-off points for automated computerised tests that are used to diagnose patients with MCI or early dementia. Additionally, the costs associated with acquiring and using these tests in clinical practice should be estimated.Study registrationThe study is registered as PROSPERO CRD42015025410.FundingThe National Institute for Health Research Health Technology Assessment programme.

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“…Depressed subjects have been shown to have greater deficits in cognitive functioning than their non-depressed counterparts. 2,3,4 A commonly used method for assessing intellectual functioning in aging individuals is the administration of the AMNART (American National Adult Reading Test). This is a task in which participants read aloud a list of irregularly spelled words, which allows the examiner to determine both the general level of education of the individual as well as their cognitive functioning based on their ability to read and correctly pronounce the words.…”

Section: Introductionmentioning

confidence: 99%

Depression is associated with lower American National Adult Reading Test scores among rural dwellers aged between 50 and 64 years in Texas: A Project FRONTIER Study

2017

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Background: Previous studies have shown that depression is associated with cognitiveimpairment. However, others have shown that there is no significant difference in the scoresof the National Adult Reading Test (NART), a screening test for intellectual functioning andgeneral level of education, between those with vs. without depression. This study sought toexamine whether depression is associated with the American version of NART (AMNART) ina rural cohort of West Texas.Methods: Participants with IQ and AMNART tests were selected from Project FRONTIER,an ongoing epidemiology study of rural residents in four West Texas counties.Results: AMNART scores were significantly lower in participants with depression(23.3±9.2) vs. those without depression (25.9±9.9) (p<0.05). Analysis by age group showedthat AMNART scores were significantly lower in those with depression (22.0±10.1) comparedwith those without depression (26.2±10.2) in the age group 50 to 64 years (P=0.0322). AlthoughAMNART scores were lower in participants with depression than those without depression inthe age groups 40 to 49 years (25.0±8.6 vs. 26.2±10.2) and 65 years or older (23.6±8.2 vs.25.6±9.5), they were not statistically significantly different.Conclusions: Depression is associated with lower AMNART scores in rural residentsaged between 50 and 64 years in West Texas.

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Cognitive differences among depressed and non‐depressed MCI participants: a project FRONTIER study

Cited by 39 publications

References 29 publications

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Automated tests for diagnosing and monitoring cognitive impairment: a diagnostic accuracy review

Depression is associated with lower American National Adult Reading Test scores among rural dwellers aged between 50 and 64 years in Texas: A Project FRONTIER Study

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