Cognitive deficits in schizophrenia: short‐term and long‐term

Kane, John M.; Lencz, Todd

doi:10.1002/j.2051-5545.2008.tb00143.x

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…They often develop in the prodromal period (Lencz, Smith, & McLaughlin, 2006; Kane & Lencz, 2008) and can be significant by the time of the first episode (Mesholam-Gately et al, 2009). Specific deficits have been found in all cognitive domains, including executive function, memory, and attention, and are between 0.5 and 1.5 standard deviations below matched control subjects (Velligan et al, 2000; Mohamed et al, 1999; Buchanan et al, 2005; Green, 2006; Zanelli et al, 2010; Bilder et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Although negative symptoms may modulate the effect of cognition on clinical outcome (Lin et al, 2013), cognition seems to be an independent, core symptom domain of schizophrenia that separately predicts long-term functional outcome and quality of life (Kane & Lencz, 2008; Keefe & Fenton, 2007; Green, Kern, & Braff, 2000). Despite the clinical and functional importance of cognitive symptoms, there are no currently approved and clearly effective pharmacologic treatments for these deficits (Harvey & Keefe, 2001; Coyle et al, 2010; Menniti et al, 2013; Choi, Wykes, & Kurtz, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Antidepressants for cognitive impairment in schizophrenia — A systematic review and meta-analysis

Vernon¹,

Grudnikoff²,

Seidman³

et al. 2014

Schizophrenia Research

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidepressants for cognitive impairment in schizophrenia — A systematic review and meta-analysis

Vernon¹,

Grudnikoff²,

Seidman³

et al. 2014

Schizophrenia Research

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“…Keefe [373] even suggested including cognitive impairment as a diagnostic criterion for schizophrenia in the DSM-V [374]. The suggestion triggered a lively debate [375], because comparable cognitive deficits are also encountered in other mental disorders [274,376].…”

Section: Negative Symptoms and Cognitive Impairmentmentioning

confidence: 99%

The Concept of Schizophrenia: From Unity to Diversity

Häfner

2014

Advances in Psychiatry

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After over 100 years of research without clarifying the aetiology of schizophrenia, a look at the current state of knowledge in epidemiology, genetics, precursors, psychopathology, and outcome seems worthwhile. The disease concept, created by Kraepelin and modified by Bleuler, has a varied history. Today, schizophrenia is considered a polygenic disorder with onset in early adulthood, characterized by irregular psychotic episodes and functional impairment, but incident cases occur at all ages with marked differences in symptoms and social outcome. Men’s and women’s lifetime risk is nearly the same. At young age, women fall ill a few years later and less severely than men, men more rarely and less severely later in life. The underlying protective effect of oestrogen is antagonized by genetic load. The illness course is heterogeneous and depressive mood the most frequent symptom. Depression and schizophrenia are functionally associated, and affective and nonaffective psychoses do not split neatly. Most social consequences occur at the prodromal stage. Neither schizophrenia as such nor its main symptom dimensions regularly show pronounced deterioration over time. Schizophrenia is neither a residual state of a neurodevelopmental disorder nor a progressing neurodegenerative process. It reflects multifactorial CNS instability, which leads to cognitive deficits and symptom exacerbations.

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“…Moreover, they seem to be connected with different aspects of functionality as an objective measure and quality of life as a subjective measure of illness outcome (Lepage et al 2014, Mesholam-Gately et al 2009, Rodriguez et al 2015. Neurocognitive decline is directly associated with poor psychosocial functioning, low work productivity and high absenteeism of persons with schizophrenia and consequently present a significant emotional and economic burden to them and the society (Chong et al 2016, Fett et al 2011, Kane & Lencz 2008, Rodriguez et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive Profiles of Patients With the First Episode of Psychosis and Schizophrenia Do Not Differ Qualitatively: A Nested Cross-Sectional Study

Kuharić¹,

Kekin²,

Bajić³

et al. 2019

Psychiat Danub

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Background: The aim of study was to analyze neurocognitive profiles in patients with first-episode psychosis (FEP) and patients with schizophrenia (SCH), and their correlations with other clinical features. Subjects and methods: We performed a multicentric cross sectional study including 100 FEP and 100 SCH recruited from three Croatian hospitals during 2015-2017. Assessment included a set of neurocognitive tests, psychiatric scales and self-reporting questionnaires. The main analysis was done by multigroup latent profile analysis. Results: Multigroup latent profile analysis resulted in three structurally equivalent neurocognitive profiles ("Best", "Medium", "Worst"), with differences in the severity of neurocognitive deficits measured with successfulness in solving domain specific tasks. The "Best" profile was statistically significantly more prevalent in FEP and "Worst" profile in the SCH. Negative symptom score was the highest in patients with the "Worst" profile and the lowest among those with the "Best" profiles. Conclusions: Differences in neurocognitive profiles between FEP and SCH appear to be quantitative rather than qualitative nature, possibly reflecting a specific trait of illness that may progress over time. Defining neurocognitive profiles from the first episode of psychosis could help in tailoring individualized treatment options with focus on neurocognitive and negative symptoms and possible influence on patients' overall clinical outcome.

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Cognitive deficits in schizophrenia: short‐term and long‐term

Cited by 9 publications

References 19 publications

Antidepressants for cognitive impairment in schizophrenia — A systematic review and meta-analysis

Antidepressants for cognitive impairment in schizophrenia — A systematic review and meta-analysis

The Concept of Schizophrenia: From Unity to Diversity

Neurocognitive Profiles of Patients With the First Episode of Psychosis and Schizophrenia Do Not Differ Qualitatively: A Nested Cross-Sectional Study

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