Cognitive deficits in patients with chronic fatigue syndrome

Marcel, Barbara; Komaroff, Anthony L.; Fagioli, Laura; Kornish, R. James; Albert, Marilyn

doi:10.1016/0006-3223(95)00422-x

Cited by 56 publications

(41 citation statements)

References 21 publications

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“…Neuropsychological testing of cognition has revealed abnormalities in patients with CFS, [54][55][56][57][58][59][60][61][62][63][64][65][66][67] abnormalities not explained by a coexisting depression. 56 A recent meta-analysis of 50 eligible studies found deficits primarily in attention, memory and reaction time, and not in fine motor speed, vocabulary, or reasoning.…”

Section: Cognitionmentioning

confidence: 99%

Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome

Komaroff

Cho²

2011

Semin Neurol

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Chronic fatiguing illnesses following well-documented infections and acute "infectious-like" illnesses of uncertain cause have been reported for many decades. Chronic fatigue syndrome (CFS) was first formally defined in 1988. There is considerable evidence that CFS is associated with abnormalities of the central and autonomic nervous systems. There also is evidence linking several infectious agents with CFS, although no agent has been proven to be a cause of the illness. Most of the infectious agents that have been linked to CFS are able to produce a persistent, often life-long, infection and thus are a constant incitement to the immune system. Most also have been shown to be neuropathogens. The evidence is consistent with the hypothesis that CFS, in some cases, can be triggered and perpetuated by several chronic infections that directly or indirectly affect the nervous system, and that symptoms are a reflection of the immune response to the infection.

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Section: Cognitionmentioning

confidence: 99%

Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome

Komaroff

Cho²

2011

Semin Neurol

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“…Although there is some inconsistency in the literature, individuals with CFS have also been found to exhibit deficits in memory when group differences are examined (DeLuca et al, 1994;Estes et al, 1984;Johnson et al, 1998;Joyce et al, 1996;Marcel et al, 1996;Michiels et al, 1996;Sandman et al, 1993). The memory deficit in CFS seems to be a consequence of difficulties in the acquisition of information.…”

Section: Introductionmentioning

confidence: 99%

“…Deficits on specific measures of executive functioning in CFS have been documented in the literature (Marcel et al, 1996;Marshall et al, 1997;McDonald et al, 1993;Ray et al, 1993;Smith et al, 1993). A variety of measures have been used to assess different aspects of executive functioning such as set shifting and conceptualization [Stroop Interference (Stroop, 1935); Proverb Interpretation (Gorham, 1956), respectively], figure copying [figures from the Wechsler Memory Scale (Wechsler, 1945)], along with processing reading passages [Salthouse Reading Span Task (Salthouse, 1994)].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological deficits in patients with chronic fatigue syndrome

Busichio

Tiersky

DeLuca

et al. 2004

J Int Neuropsychol Soc

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The degree of neuropsychological dysfunction across multiple domains was examined in individuals suffering from chronic fatigue syndrome (CFS). In this descriptive study, a similar series of neuropsychological tests was administered to a group of CFS patients and healthy participants. More specifically, CFS patients (n = 141) who met the 1994 Case Definition criteria were compared to 76 healthy control participants on tests of memory, attention (concentration), speed of information processing, motor speed, and executive functioning. On the 18 measures administered, CFS patients scored 1 standard deviation below the healthy mean on nine measures and scored 2 standard deviations below the healthy mean on four of the measures. Moreover, results indicated that CFS patients were more likely than healthy controls to fail (1.6 SD below the healthy mean) at least one test in each of the following domains: attention, speed of information processing, and motor speed, but not on measures of memory and executive functioning. Finally, CFS patients demonstrated a greater total number of tests failed across domains.

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“…For example, patients with CFS report an increased perception of muscular effort despite submaximal performance on exercise testing (Stokes et al 1988 ;Riley et al 1990), but the same may be true in depression, where impairment of motor function extends even to maximal voluntary hand grip (Cohen et al 1982 ;Moffoot et al 1994). Subjective reports of cognitive impairment in CFS are supported by objective evidence for slowed reaction time and poor memory or attention (Millon et al 1989 ;Altay et al 1990 ;Riccio et al 1992 ;Grafman et al 1993 ;MacDonald et al 1993 ;Ray et al 1993 ;Sandman et al 1993 ;Schmaling et al 1994 ;Cope et al 1995 ;DeLuca et al 1995 ;Joyce et al 1996 ;Marcel et al 1996 ;Marshall et al 1997 ;Vollmer-Conna et al 1997 ;Wearden & Appleby, 1997 ;Johnson et al 1998). A comparison with depression suggests a similar pattern of impairments (e.g.…”

Section: Introductionmentioning

confidence: 99%

The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness

Lawrie

MacHale²,

Cavanagh³

et al. 2000

Psychol. Med.

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Background. Chronic fatigue syndrome (CFS) and major depressive disorder (MDD) share many symptoms and aetiological factors but may have different neurobiological underpinnings. We wished to determine the profile of the biological variables disturbed in CFS and MDD, and identify any critical factors that differentiate the disorders. Methods. Thirty patients with CFS, 20 with MDD and 15 healthy controls -matched group-wise for age and sex -were recruited. Subjects were given a detailed battery of motor and cognitive tests, including measures of psychomotor speed, memory and maximal voluntary muscle contraction in both the morning and evening that were balanced to avoid order effects. Results. CFS patients generally performed worse on cognitive tests than healthy controls, but better than patients with MDD. Both patient groups had markedly impaired motor function compared with healthy controls. MDD subjects showed a significantly greater diurnal improvement in maximal voluntary contraction than healthy controls. Conclusions. Patients with CFS and MDD show similarly substantial motor impairment, but cognitive deficits are generally more marked in MDD. Diurnal changes in some functions in MDD may differentiate the disorder from CFS.

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Cognitive deficits in patients with chronic fatigue syndrome

Cited by 56 publications

References 21 publications

Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome

Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome

Neuropsychological deficits in patients with chronic fatigue syndrome

The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness

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