Cognitive deficits in children with autism spectrum disorders: Toward an integrative approach combining social and non-social cognition

Hajri, M.; Abbès, Zeineb; Yahia, Houda Ben; Jelili, Sélima; Halayem, Soumeyya; Mrabet, Ali; Bouden, Asma

doi:10.3389/fpsyt.2022.917121

Cited by 12 publications

(8 citation statements)

References 42 publications

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“…As mentioned for behavioral problems, cognitive impairment, in all its facets, can also be found in ASD patients [ 67 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 ]. In ASD patients, ID is significantly associated with epilepsy [ 122 , 123 ], and the prevalence of the latter is higher in ASD patients with ID compared with ASD patients without ID [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review

Bosetti,

Ferrini,

Ferrari

et al. 2024

JCM

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Over the last decade, the comorbidity between Autism Spectrum Disorder (ASD) and epilepsy has been widely demonstrated, and many hypotheses regarding the common neurobiological bases of these disorders have been put forward. A variable, but significant, prevalence of abnormalities on electroencephalogram (EEG) has been documented in non-epileptic children with ASD; therefore, several scientific studies have recently tried to demonstrate the role of these abnormalities as a possible biomarker of altered neural connectivity in ASD individuals. This narrative review intends to summarize the main findings of the recent scientific literature regarding abnormalities detected with standard EEG in children/adolescents with idiopathic ASD. Research using three different databases (PubMed, Scopus and Google Scholar) was conducted, resulting in the selection of 10 original articles. Despite an important lack of studies on preschoolers and a deep heterogeneity in results, some authors speculated on a possible association between EEG abnormalities and ASD characteristics, in particular, the severity of symptoms. Although this correlation needs to be more strongly elucidated, these findings may encourage future studies aimed at demonstrating the role of electrical brain abnormalities as an early biomarker of neural circuit alterations in ASD, highlighting the potential diagnostic, prognostic and therapeutic value of EEG in this field.

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Section: Discussionmentioning

confidence: 99%

Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review

Bosetti,

Ferrini,

Ferrari

et al. 2024

JCM

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“…Children diagnosed with ASD show increased sleep disturbances (Krakowiak et al, 2008) and shorter sleep duration (Veatch et al, 2017). These differences in sleep likely result in skewed developmental trajectories, resulting in the life-long cognitive and social deficits (Hajri et al, 2022). The disruption of sleep in early life may increase vulnerability of individuals towards the development of ASD.…”

Section: Introductionmentioning

confidence: 99%

Sex-Specific Impacts of Early Life Sleep Disruption: Ethanol Seeking, Social Interaction, and Anxiety Are Differentially Altered in Adolescent Prairie Voles

Ginder,

Tinsley,

Kaiser

et al. 2024

Preprint

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Early life sleep is important for neuronal development and maturation. Using the highly social prairie vole rodent model, we have previously reported that early-life sleep disruption (ELSD) during the pre-weaning period postnatal day (P)14 to 21 results in adult interference with social bonding and increases ethanol consumption following a stressor. Furthermore, we have reported increased parvalbumin expression and reduced glutamatergic neurotransmission in cortical regions in adult prairie voles that experienced this paradigm. To understand the impact of ELSD on the lifespan, examination of an earlier time in life is necessary. Thus, the aim of the present study was to examine the behavioral outcomes of ELSD on adolescent prairie voles. Here we hypothesized that anxiety and reward related behaviors, as measured by light/dark box, 2-bottle choice and social interactions, would be negatively impacted by ELSD in adolescent male and female prairie voles. Male ELSD voles were no different from control voles in measures of anxiety and ethanol preference or consumption, but affiliative social interactions were significantly reduced. ELSD differentially impacted female prairie voles, with increased anxiety-like behavior and reductions in ethanol consumption compared to Controls, but no impact on ethanol preference or social interactions. Together, these results suggest both male and female prairie voles experience differential changes to reward seeking behaviors, but only female prairie voles showed increases in anxiety-like behavior. These results further suggest that early-life sleep is critically important for neurotypical behaviors in adolescence, a time where reward-seeking and risky behaviors are adaptive for learning and promoting survival.

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“…Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders marked by social interaction, communication difficulties and cognitive deficits [1,2], as well as repetitive or restricted behaviors. Over the past decade, the global prevalence of ASD has increased, and the disorder is four times more likely to occur in boys than in girls [3,4].…”

Section: Introductionmentioning

confidence: 99%

Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder

Prince,

Peralta Marzal,

Markidi

et al. 2024

Acta Pharmacol Sin

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Autism spectrum disorder (ASD) is a cluster of neurodevelopmental disorders characterized by deficits in communication and behavior. Increasing evidence suggests that the microbiota-gut-brain axis and the likely related immune imbalance may play a role in the development of this disorder. Gastrointestinal deficits and gut microbiota dysfunction have been linked to the development or severity of autistic behavior. Therefore, treatments that focus on specific diets may improve gastrointestinal function and aberrant behavior in individuals with ASD. In this study, we investigated whether a diet containing specific prebiotic fibers, namely, 3% galacto-oligosaccharide/fructo-oligosaccharide (GOS/FOS; 9:1), can mitigate the adverse effects of in utero exposure to valproic acid (VPA) in mice. Pregnant BALB/cByJ dams were injected with VPA (600 mg/kg, sc.) or phosphate-buffered saline (PBS) on gestational day 11 (G11). Male offspring were divided into four groups: (1) in utero PBS-exposed with a control diet, (2) in utero PBS-exposed with GOS/FOS diet, (3) in utero VPA-exposed with a control diet, and (4) in utero VPA-exposed with GOS/FOS diet. Dietary intervention started from birth and continued throughout the duration of the experiment. We showed that the prebiotic diet normalized VPA-induced alterations in male offspring, including restoration of key microbial taxa, intestinal permeability, peripheral immune homeostasis, reduction of neuroinflammation in the cerebellum, and impairments in social behavior and cognition in mice. Overall, our research provides valuable insights into the gut-brain axis involvement in ASD development. In addition, dietary interventions might correct the disbalance in gut microbiota and immune responses and, ultimately, might improve detrimental behavioral outcomes in ASD.

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Cognitive deficits in children with autism spectrum disorders: Toward an integrative approach combining social and non-social cognition

Cited by 12 publications

References 42 publications

Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review

Children with Autism Spectrum Disorder and Abnormalities of Clinical EEG: A Qualitative Review

Sex-Specific Impacts of Early Life Sleep Disruption: Ethanol Seeking, Social Interaction, and Anxiety Are Differentially Altered in Adolescent Prairie Voles

Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder

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