Cognitive Deficits before Treatment among Patients with Brain Tumors

Tucha, Oliver; Smely, Christian; Preier, Michael; Lange, Klaus W.

doi:10.1097/00006123-200008000-00011

Cited by 323 publications

(180 citation statements)

References 24 publications

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“…Interestingly, different sub-groups of patients emerged at T1. There were patients who became pathological, expressing the effect of resection; patients who remained as impaired as they had been at T0 (stable), expressing the effect of lesion, in line with, Tucha et al [2] study showing that a deficit in design fluency can be detected pre-surgery. There were also patients who had been pathological at T0 and recovered at T1, possibly expressing the effect of flexible adaptation/amelioration.…”

Section: Discussionsupporting

confidence: 73%

“…It is known that a deficit in design fluency can emerge in neurosurgical patients as an effect of lesion, thus detected prior to surgery [2], or can arise post-surgery [4][5][6], as an effect of tumor resection. In a recent meta-analysis [7] the need of more studies with longer post-op cognitive follow-up testing to better understand the conclusive effects of glioma surgery on cognition has been highlighted.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that a deficit in design fluency can emerge in neurosurgical patients as an effect of lesion, thus detected prior to surgery, or can arise post-surgery, as an effect of tumor resection. For instance, Tucha et al [2] studied 161 presurgical patients and found impaired design fluency in 74 of them. Unfortunately, no data about their post-surgical performance is available.…”

Section: Introductionmentioning

confidence: 99%

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Recovering and Worsening at Design Fluency in 22 Neurosurgical Patients: Preimmediately Post-surgery and Follow-up Testing

Tomasino

Marin

Madotto

et al. 2017

Int J Phys Med Rehabil

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The five-point test (FPT) measures the ability to voluntarily generate non-verbal novel patterns. We investigated how this ability can be impaired or improved before immediately after brain surgery, and at follow-up. Twenty-two patients undergoing neurosurgery in the right hemisphere performed the FPT at T0 (pre-), T1 (1 week post-), and T2 (follow-up at 5 months after surgery). Significant improvements at T1 (in patients who had a deficit at T0) measured recovering (N=3/22); in addition there were patients who become pathological (8/22) and subjects who presented with the same degree of impairment as observed at T0 (stable, 1/22). Similarly, at T2 (4-5 months after surgery) we measured the effect of post-op reorganization: there were patients (5/22) who had been pathological at T1 and recovered at T2. Lesions overlapped in the right body of the corpus callosum/anterior cingulum reflecting the overcome of the deficit. Amelioration can be an effect of edema reduction. In addition, there were those who become pathological (4/22). Lesions overlapped in the right supramarginal gyrus. Lastly, there were subjects who presented with the same degree of impairment as observed at T1 (stable, 4/22) and those who remained spared (9/22). Multiple regression analysis was used to test if the number of strategies (CSs) used to solve the task or the perseverative behaviour (ErrI) significantly predicted participants' stratification, namely patients who worsened those who improved and patients who remained spared. It was found that the use of strategies significantly predicted participants' stratification, whereas perseverative behaviour was not a significant predictor.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recovering and Worsening at Design Fluency in 22 Neurosurgical Patients: Preimmediately Post-surgery and Follow-up Testing

Tomasino

Marin

Madotto

et al. 2017

Int J Phys Med Rehabil

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“…Poorer recall of more distant phone use by cases is conceivable if, for example, long-term memory in brain tumour cases was more affected than short-term memory. There is considerable literature on memory impairment and cognitive dysfunction in people with brain tumours (Salander et al, 1995;Weitzner and Meyers, 1997;Tucha et al, 2000), but evidence concerning long-term memory is limited. In any case, memory problems in brain tumour cases would be expected to lead to more random error rather than more overreporting.…”

Section: Discussionmentioning

confidence: 99%

Recall bias in the assessment of exposure to mobile phones

Vrijheid

Armstrong

Bedard

et al. 2008

J Expo Sci Environ Epidemiol

128

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Most studies of mobile phone use are case-control studies that rely on participants' reports of past phone use for their exposure assessment. Differential errors in recalled phone use are a major concern in such studies. INTERPHONE, a multinational case-control study of brain tumour risk and mobile phone use, included validation studies to quantify such errors and evaluate the potential for recall bias. Mobile phone records of 212 cases and 296 controls were collected from network operators in three INTERPHONE countries over an average of 2 years, and compared with mobile phone use reported at interview. The ratio of reported to recorded phone use was analysed as measure of agreement. Mean ratios were virtually the same for cases and controls: both underestimated number of calls by a factor of 0.81 and overestimated call duration by a factor of 1.4. For cases, but not controls, ratios increased with increasing time before the interview; however, these trends were based on few subjects with long-term data. Ratios increased by level of use. Random recall errors were large. In conclusion, there was little evidence for differential recall errors overall or in recent time periods. However, apparent overestimation by cases in more distant time periods could cause positive bias in estimates of disease risk associated with mobile phone use.

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“…Una de las manifestaciones clínicas más frecuentes en estos pacientes son los défi-cits cognitivos, que se asocian a su vez a elevada morbilidad y a una negativa en su calidad de vida (3)(4)(5) , los que convierte a los tumores cerebrales en una de las principales patologías neurológicas con este tipo de sintomatología (6) . Sin embargo, los datos de prevalencia sobre los déficits cognitivos en pacientes con tumores cerebrales son muy dispersos en función de los diferentes estudios, oscilando los porcentajes entre el 12% y el 90%, durante todo el proceso de la enfermedad (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) . En lo que sí parece haber acuerdo en la literatura, es respecto a los dominios cognitivos que presentan mayor afectación en estos enfermos (16,(18)(19)(20)(21)(22)(23) , entre los que cabe destacar: -Atención: velocidad de procesamiento de la información y atención alternante.…”

Section: Introductionunclassified

Rehabilitación neuropsicológica en pacientes con tumores cerebrales

Cortés¹,

Crespo

2014

Psicooncología

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ResumenLos déficits cognitivos son uno de los sínto-mas más frecuentes en pacientes con tumores cerebrales, principalmente en atención, memoria y funciones ejecutivas. Estas alteraciones impactan de forma negativa en al calidad de vida de los pacientes y en su reincorporación a su funcionamiento diario. En los últi-mos años se están desarrollando programas de Rehabilitación Neuropsicológica en pacientes adultos con tumores cerebrales, con resultados positivos. Así, los autores recomiendas que las intervenciones incluyan técnicas de psico-educación, estrategias de recuperación de los diferentes procesos atencionales y de ejecutivos (planificación y organización), así como técni-cas compensatorias para la memoria. Los trabajos publicados hasta la fecha muestran mejoría inmediatamente después de la intervención en atención y memoria. Sin embargo, no existen datos del impacto de estos programas de Rehabilitación en el rendimiento de estos pacientes a medio y largo plazo (más de seis meses). Futuros estudios necesitan evaluar la eficacia de este tipo de intervención en pacientes mayores con tumores cerebrales, así como diferenciar los resultados en función del tipo de tumor y de los tratamientos oncológicos aplicados, ya que estas dos características pueden afectar de forma significativa a los datos obtenidos.Palabras clave: tumores cerebrales, pacientes adultos, Rehabilitación Neuropsicológica. The authors recommend that interventions include psychoeducation techniques, recovery strategies of different attentional and executive processes (planning and organization) and compensatory techniques for memory. The studies published to date show improvement immediately after surgery in attention and memory. However, there are not data exist on the impact of these programs on performance rehabilitation of these patients in the medium and long term (over six months). The future studies need to evaluate the effectiveness of this intervention in elderly patients with brain tumors, and the results differ depending on the type of tumor and cancer treatments applied, as these two features can significantly affect the data obtained.

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Cognitive Deficits before Treatment among Patients with Brain Tumors

Cited by 323 publications

References 24 publications

Recovering and Worsening at Design Fluency in 22 Neurosurgical Patients: Preimmediately Post-surgery and Follow-up Testing

Recovering and Worsening at Design Fluency in 22 Neurosurgical Patients: Preimmediately Post-surgery and Follow-up Testing

Recall bias in the assessment of exposure to mobile phones

Rehabilitación neuropsicológica en pacientes con tumores cerebrales

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