Cognitive deficits and levels of IQ in adolescent onset schizophrenia and other psychotic disorders☆

Fagerlund, Birgitte; Pagsberg, Anne Katrine; Hemmingsen, Ralf

doi:10.1016/j.schres.2006.03.004

Cited by 64 publications

(48 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association with premorbid cognitive functioning has been infrequently studied for ONAP. 9,12 Consistent with most prior studies, 9,18,19 we found that the association of ONAP with SA in males was identical to that seen for SZ. Interestingly, in females, it was modestly weaker.…”

Section: Discussionsupporting

confidence: 91%

A Swedish National Prospective and Co-relative Study of School Achievement at Age 16, and Risk for Schizophrenia, Other Nonaffective Psychosis, and Bipolar Illness

Kendler¹,

Mezuk

Sundquist

et al. 2015

SCHBUL

View full text Add to dashboard Cite

While cognitive ability is inversely associated with risk for schizophrenia (SZ), the association is less clear with other nonaffective psychoses (ONAP) and bipolar illness (BPI). Using national Swedish hospital registry dataThe association between SA and risk was stronger in the lower vs the higher ranges of SA. In most analyses, moderate increases in risk were observed at the highest levels of SA, with the strongest evidence for females and risk of ONAP. Co-relative control analyses indicated that common genetic or familial-environmental effects only marginally confounded these associations. Consistent with prior studies, these results have 3 major implications for neurodevelopmental models: (1) adolescent cognitive deficits that increase risk are not the result of prodromal changes,( 2) individual specific environmental exposures are largely responsible for the association between low SA and psychosis risk, and (3) neurodevelopmental disturbances (as indicated by low SA) are not unique to SZ but also occur in ONAP and to a lesser degree BPI.Key words: Cognitive ability/school performance/ schizophrenia/bipolar illness/other nonaffective psychoses/prospective risk/co-relative control analysis A series of meta-analyses have convincingly shown that cognitive ability is inversely related to risk for future schizophrenia (SZ) onsets 1-4 although a question remains whether this relationship holds at the highest levels of cognitive performance. 3,5,6 The association between cognitive functioning and risk for bipolar illness (BPI) is less consistent, 7-10 with some evidence that higher cognitive functioning is associated with elevated risk. 10,11 The relationship between cognitive performance and risk for other nonaffective psychosis (ONAP) has been less studied but extant research suggests that it resembles the relationship seen for SZ. 9,12 In our prior study of cognitive ability indexed by IQ, IQ obtained at military conscription at age 18-20 had a strong and monotonic inverse relationship with risk for onset of SZ in Swedish males.6 Co-relative analyses suggested that the IQ-SZ relationship was not due to genetic or environmental familial risk factors that predisposed both to low IQ and SZ. While some prior reports, including a Finnish longitudinal study, found enrichment for cases of SZ among those with the highest level of cognitive functioning (indicating an inverted J-shaped relationship between performance and SZ risk), 3,5 we found no evidence that high IQ is associated with increased risk for SZ. However, our study was unable to investigate this relationship at the highest end of the IQ distribution because the highest performing group in our study had a mean IQ of 129, slightly less than 2 standard deviations above the mean.In the present study, we had access to a measure of aggregate school achievement (SA) at age 16 in a nearly complete sample of native Swedish children of both sexes born between 1972 and 1990 (n = 1 800 643). While substantially correlated, SA is not identical to IQ and has Downloaded ...

show abstract

Section: Discussionsupporting

confidence: 91%

A Swedish National Prospective and Co-relative Study of School Achievement at Age 16, and Risk for Schizophrenia, Other Nonaffective Psychosis, and Bipolar Illness

Kendler¹,

Mezuk

Sundquist

et al. 2015

SCHBUL

View full text Add to dashboard Cite

show abstract

“…Furthermore, patients with EOS demonstrate significant cognitive impairments in specific domains, mainly general intellectual ability [36][37][38][39][40][41][42], memory [43][44][45][46][47], attention [43,48,49], and executive function [46,48,50,51]. Studying early-onset cases may provide important insights into the etiopathogenesis of the disorder [50][51].…”

Section: Children and Adolescents With Schizophreniamentioning

confidence: 99%

Theory of Mind in the Early Course of Schizophrenia

Vyas

et al. 2017

CPSR

View full text Add to dashboard Cite

Theory of mind deficit is a core feature of schizophrenia and is considered a vulnerability marker of the disorder. The majority of studies measuring theory of mind in schizophrenia involve multiple-episode or chronic schizophrenia patients, and therefore it is important to delineate whether these deficits occur before or following illness-onset by assessing high-risk subjects (clinical high risk and ultra-high risk), early-onset psychosis, and first-degree relatives. We address the question of whether theory of mind impairment is specific or a facet of general cognitive impairment in these clinical populations, and incorporate genetic and neuroimaging studies on theory of mind. The review provides a succinct evaluation of the literature, discusses current limitations and proposes future directions.

show abstract

“…[21] изучался когнитивный дефицит в двух группах подростков (сред-ний возраст 15,2 года): 18 больных с диагнозом «рано на-чавшаяся шизофрения» и 21 -с другими психозами. Средние показатели интеллекта у обследованных больных на 2 / 3 -1 стандартное отклонение отставали от норматив-ных средних.…”

unclassified

“…Среди других отличий больных подростков авторы указывают на показатель «времени инициации мышления» (initial thinking time), который в обеих группах больных значительно меньше, чем в кон-троле. На основании этого сделан вывод, что больные бы-стрее планируют выполнение того или иного задания, но не отличаются во времени их решения [21].…”

unclassified

Variants of cognitive development in children and adolescents with different forms of schizophrenia

Zvereva¹,

Хромов²

2014

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

В современных работах по детской и юношеской ши-зофрении большое внимание уделяется оценке когнитив-ного и личностного развития больных, а также состоянию лиц из групп высокого риска по шизофрении [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. В литературе одним из ключевых понятий является «ког-нитивный дефицит», которое в клинической психологии используется более 40 лет, особенно часто в исследовани-ях последних 20 лет [18][19][20]. Тем не менее работы по изу-чению когнитивного дефицита при отдельных видах пси-хической патологии у подростков, а тем более детей, встречаются крайне редко в сравнении с аналогичными исследованиями у взрослых больных. При этом чаще встречаются работы, посвященные анализу отдельных по-казателей когнитивного функционирования, проводимые в сопоставлении со здоровыми сверстниками или взрос-лыми больными. Редко встречаются указания на какие-либо специфические особенности когнитивного профиля больных, свойственные тому или иному виду патологии. Цель исследования. Изучение когнитивных нарушений у детей и подростков при шизофрении с позиции концепции когнитивного дизонтогенеза с оценкой степени его выраженности и специфики, а также вариантов динамики и типов когнитивного развития. Материал и методы. Обследовали 3 группы пациентов. 1-я группа из 31 больного с детским типом шизофрении, 2-я группа из 91 больного страдала шизотипическим расстройством, в 3-ю группу вошли 19 больных с разными формами шизофрении (аналогичными таковым у взрослых пациентов). Результаты и обсуждение. Установлено преобладание вариантов когнитивного развития, относящихся к когнитивному дизонтогенезу, структура которого определяется сочетанием признаков динамики познавательного развития и выраженности когнитивного дефицита. При этом выявлено, что выраженность и характер динамики когнитивного дефицита зависят от особенностей клинических проявлений шизофрении и степени развития познавательных процессов. Ключевые слова: когнитивное развитие, дефицит, когнитивный дизонтогенез, шизофрения, психологическая диагностика, дети и подростки.Objective. To explore cognitive disorders in children and adolescents with schizophrenia from the perspective of cognitive dysontogenesis concept, assess severity and specificity of cognitive deficits and identify variants of the dynamics and types of cognitive development. Material and methods. Three diagnostic groups of patients were studied: 1) childhood onset schizophrenia, 2) schizotypal disorder, and 3) other types of schizophrenia. Results and сonclusion. There was a predomination of cognitive development types, named cognitive dysontogenesis, which structure was determined by a combination of the dynamics of cognitive development and severity of cognitive deficits. Severity and type of the dynamics of cognitive deficits were associated with the diagnosis and cognitive process.

show abstract

Cognitive deficits and levels of IQ in adolescent onset schizophrenia and other psychotic disorders☆

Cited by 64 publications

References 54 publications

A Swedish National Prospective and Co-relative Study of School Achievement at Age 16, and Risk for Schizophrenia, Other Nonaffective Psychosis, and Bipolar Illness

A Swedish National Prospective and Co-relative Study of School Achievement at Age 16, and Risk for Schizophrenia, Other Nonaffective Psychosis, and Bipolar Illness

Theory of Mind in the Early Course of Schizophrenia

Variants of cognitive development in children and adolescents with different forms of schizophrenia

Contact Info

Product

Resources

About