Cognitive Decline in Patients with Leukoaraiosis Within 5 Years after Initial Stroke

Kumral, Emre; Gulluoglu, Halil; Alakbarova, Naila; Deveci, Emrah Emre; Çolak, Ayşe; Çağında, Ayşe D.; Evyapan, Dilek; Orman, Mehmet

doi:10.1016/j.jstrokecerebrovasdis.2015.06.012

Cited by 17 publications

(13 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the different degree of cognitive impairments between svMCI and SVaD patients, we speculated that subcortical ischemic lesions (e.g., WMH or multiple lacunar infarctions) do not correlate with cognitive impairments directly, which is incompatible with previous researches that subcortical ischemic lesions, such as leukoaraiosis, are associated with cognitive deficits (Kumral et al, 2015;Lamar et al, 2011). According to the conclusion in our study that the cerebral GM volume reduction in both svMCI patients and SVaD patients correlates with cognitive impairments, we speculate that it is cerebral GM volume reduction that results in cognitive impairments, rather than subcortical ischemic lesions.…”

Section: Discussioncontrasting

confidence: 70%

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Meng

Wang

et al. 2017

Brain and Behavior

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 70%

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Meng

Wang

et al. 2017

Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…In particular, this study confirmed the strong association between WMLs and lacunar strokes and highlighted that WMLs have an even stronger association with intracerebral hemorrhages. In addition, considering the predisposition to cognitive impairment characterizing patients with WMLs, the search for factors capable of predicting WMLs development is of considerable interest. M‐mode echocardiography provides a simple parameter, ie, RWT, which is associated with an almost triple relative risk of WMLs.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to unveiling a predisposition to stroke in general (and to lacunar strokes in particular), WMLs are frequently found in the presence of cognitive impairment, of which they are an important predictive factor …”

mentioning

confidence: 99%

“…In addition to unveiling a predisposition to stroke in general (and to lacunar strokes in particular), [2][3][4] WMLs are frequently found in the presence of cognitive impairment, of which they are an important predictive factor. [5][6][7] There are two main risk factors for WMLs: advanced age 8,9 and high blood pressure (BP). [10][11][12] The latter in particular also predisposes patients to all types of stroke, both ischemic and hemorrhagic.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Hypertension and Other Determinants of White Matter Lesions in Stroke Patients

Muscari

Faccioli

Ghinelli

et al. 2016

J of Clinical Hypertension

View full text Add to dashboard Cite

Hypertension is the main risk factor for both white matter lesions (WMLs) and stroke, but many stroke patients do not have WMLs. To find specific determinants of WMLs, the authors assessed 321 ischemic and hemorrhagic stroke patients who had undergone echocardiography. The patients with WMLs (n=160) were more often hypertensive and had a higher systolic blood pressure than the patients without WMLs. However, in a multivariate analysis, only the following variables remained associated with WMLs: (1) age: odds ratio [OR], 1.08 per year (95% confidence interval [CI], 1.06-1.11); (2) left ventricular relative wall thickness (RWT) ≥0.52: OR, 2.78 (95% CI, 1.59-4.88); (3) lacunar strokes: OR, 4.15 (95% CI, 1.83-9.44); (4) hemorrhagic strokes: OR, 5.36 (95% CI, 1.57-18.39); and (5) female: OR, 1.91 (95% CI, 1.12-3.27). Thus, the main modifiable risk factor for WMLs was RWT, which proved to be an even stronger risk factor than hypertension. This suggests that RWT might be a useful target in the treatment of hypertension to counteract the appearance of WMLs.

show abstract

“…In the event of a proximal large vessel occlusion, the downstream tissue is at increased risk of infarction. In the phase following acute stroke, severe LA may also be a major impediment to restoration of new neural networks and, therefore, stroke recovery [12,13]. We assessed the effect of baseline LA on clinical outcome at 3 months in a homogenous cohort of patients with M1 middle cerebral artery (MCA) occlusions treated successfully with MT techniques.…”

Section: Introductionmentioning

confidence: 99%

Severe Leukoaraiosis Is Associated with Poor Outcome after Successful Recanalization of M1 Middle Cerebral Artery Occlusion Strokes

Mutzenbach

Müller-Thies-Broussalis

Killer‐Oberpfalzer

et al. 2020

Cerebrovasc Dis

View full text Add to dashboard Cite

Background: Severe leukoaraiosis (LA) is an established risk factor for poor outcome after mechanical thrombectomy (MT) for large vessel occlusion stroke. There is uncertainty whether this association also applies to successfully recanalized patients with M1 segment middle cerebral artery (MCA) occlusions. Methods: A retrospective single-centre study of patients with successful reperfusion (thrombolysis in cerebral infarction, TICI 2b or 3) after MT for an M1 MCA occlusion was performed over a 7-year period. LA score (LAS) was assessed using the age-related white matter change scale on pre-interventional brain imaging. Results: A total of 209 patients (median age 75.0 years) were included. LAS was assessed on pre-interventional imaging by computed tomography in 177 (84.7%) patients and magnetic resonance imaging in 32 (15.3%) patients. The median LAS was 1 (IQR 0-8), and severe LA consisted of the top 25 percentile, ranging from 9 to 24. Multivariable analysis demonstrated an association of severe LA (OR 0.32, 95% CI 0.12-0.88, p = 0.023), higher NIHSS on admission (OR 0.89, 95% CI 0.84-0.94, p < 0.001), advanced age (OR 0.97, 95% CI 0.95-1.00, p = 0.039), good leptomeningeal collaterals (OR 3.65, 95% CI 1.46-8.15, p = 0.001), and TICI 3 score (OR 3.26, 95% CI 10.52-7.01) with good clinical outcome after 3 months as measured with the modified Rankin scale. Conclusion: Severe LA is associated with poor clinical outcome at 3 months in acute stroke patients undergoing MT due to emergent M1 MCA occlusion.

show abstract

Cognitive Decline in Patients with Leukoaraiosis Within 5 Years after Initial Stroke

Cited by 17 publications

References 42 publications

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Hypertension and Other Determinants of White Matter Lesions in Stroke Patients

Severe Leukoaraiosis Is Associated with Poor Outcome after Successful Recanalization of M1 Middle Cerebral Artery Occlusion Strokes

Contact Info

Product

Resources

About