Cognitive control in alcohol use disorder: deficits and clinical relevance

Wilcox, Claire; Dekonenko, Charlene J.; Mayer, Andrew R.; Bogenschutz, Michael P.; Turner, Jessica A.

doi:10.1515/revneuro-2013-0054

Cited by 132 publications

(121 citation statements)

References 225 publications

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“…There are behaviours or actions that can act like 'drugs', lead to craving, compulsion-like behaviours and even to behavioural addictions because of their rewarding nature [25,30,32]. Everitt & Robbins [33] suggest that an initial conscious choice to engage with a stimulus (a game, sports, certain smart phone apps, social media, hyper-palatable foods, etc.…”

Section: When It Goes Wrong: Addictionmentioning

confidence: 99%

Pleasure junkies all around! Why it matters and why ‘the arts’ might be the answer: a biopsychological perspective

Christensen

2017

Proc. R. Soc. B.

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Today's society is pleasure seeking. We expect to obtain pleasurable experiences fast and easily. We are used to hyper-palatable foods and drinks, and we can get pornography, games and gadgets whenever we want them. The problem: with this type of pleasure-maximizing choice behaviour we may be turning ourselves into mindless pleasure junkies, handing over our free will for the next dopamine shoot. Pleasure-only activities are fun. In excess, however, such activities might have negative effects on our biopsychological health: they provoke a change in the neural mechanisms underlying choice behaviour. Choice behaviour becomes biased towards short-term pleasure-maximizing goals, just as in the addicted brain (modulated by the amygdala, posterior ventromedial prefrontal cortex' (VMPFC), striatum, nucleus accumbens; ‘A-system’) and away from long-term prosperity and general well-being maximizing objectives (normally ensured by the insula, anterior VMPFC, hippocampus, dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC); ‘I-system‘). This paper outlines, first, what ‘pleasure’ is and what ‘pleasure-only’ activities are (e.g. social media engagement, hyper-palatable eating). Second, an account is given of the type of action that might aid to maintain the neural systems underlying choice behaviour balanced. Finally, it is proposed that engagement with the arts might be an activity with the potential to foster healthy choice behaviour—and not be just for pleasure. The evidence in this rather new field of research is still piecemeal and inconclusive. This review aims to motivate targeted research in this domain.

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Section: When It Goes Wrong: Addictionmentioning

confidence: 99%

Pleasure junkies all around! Why it matters and why ‘the arts’ might be the answer: a biopsychological perspective

Christensen

2017

Proc. R. Soc. B.

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“…A meta-analysis conducted by Wilcox et al [7] has revealed consistent results regarding response inhibition deficits in AUD, while less consistent findings were observed for working memory and distractor interference control. Similar findings were reported in a subsequent study: alcohol consumption had a direct impact on response inhibition and working memory [5].…”

Section: Introductionmentioning

confidence: 96%

“…However, this definition of cognitive control is similar to the concept of executive function. In fact, some authors [7] consider cognitive control to be a subset of executive function. At the same time, Lezak et al [12] define executive function as individual capacities that allow a person to successfully engage in independent, purposive, selfdirected and self-serving behavior.…”

Section: Introductionmentioning

confidence: 99%

“…According to Miyake et al [14], these three functions have either no linear relationship or very weak intercorrelations, which reflects their independence. The Three Function Theory approach has been used in many AUD studies, but all three functions were not tested simultaneously [5,7]. The most widely studied cognitive control components include response inhibition, distractor interference and working memory.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive control in patients with alcohol use disorder: testing a three-function model

Trusova¹,

Klimanova

Berezina

et al. 2018

Arch Psych Psych

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“…Several anatomical studies of the alcoholic brain show that changes in the hippocampus, extrahippocampal cortex, and basal forebrain can induce memory dysfunction [7] and learning disabilities [8]. Although the mechanisms having a role in chronic alcohol treatment-induced neurotoxic actions have not yet been clearly identified, different investigations have hypothesized that alcohol intake (i.e.…”

Section: Introductionmentioning

confidence: 99%

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Carito¹

2015

J Alcohol Drug Depend

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Many studies have suggested possible relationships between the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) and alcohol addiction. Previous reports demonstrated severe changes in these neurotrophins in the serum of alcohol dependent patients and during withdrawal. Alcohol dependence syndromes during consumption and/or withdrawal are also characterized by elevated oxidative stress. Polyphenols, including olive polyphenols, are natural compounds known to possess marked antioxidant properties. Thus, this study was carried out in order to verify the effects of a blend of olive polyphenols supplementation containing mostly hydroxytyrosol (50 mg/day for 15 consecutive days) in alcoholic men during withdrawal on serum BDNF and NGF. As controls a group of alcohol dependent patients received sucrose tablets as placebo. BDNF and NGF were measured by ELISA on day 1, 3, 7 and 15 of the detoxification period. Some parameters of oxidative stress were analyzed too as free oxygen radicals defense (FORD) and free oxygen radicals test (FORT). No differences in oxidative status due to polyphenols were found. However, withdrawal elicited a mild increase in BDNF over two weeks that was counteracted on day 3 by polyphenols. As for NGF no effects of polyphenols supplementation were discovered to antagonize the expected NGF serum elevation during withdrawal. In conclusion the present data may indicate that monitoring serum BDNF and/or NGF in alcoholics undergoing detoxification could contribute to characterize alcohol dependence profiles to improve recovery processes throughout also antioxidant compounds.

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Cognitive control in alcohol use disorder: deficits and clinical relevance

Cited by 132 publications

References 225 publications

Pleasure junkies all around! Why it matters and why ‘the arts’ might be the answer: a biopsychological perspective

Pleasure junkies all around! Why it matters and why ‘the arts’ might be the answer: a biopsychological perspective

Cognitive control in patients with alcohol use disorder: testing a three-function model

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

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