Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia

Horimoto, Yoshihiko; Matsumoto, Mitsuhiro; Nakazawa, Hideka; Yuasa, Hiroyuki; Morishita, Manabu; Akatsu, Hiroyasu; Ikari, Hiroyuki; Yamamoto, Takayuki; Kosaka, Kenji

doi:10.1016/s0022-510x(03)00220-x

Cited by 35 publications

(26 citation statements)

References 14 publications

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“…PDD and DLB can be classified into two neuropathological subtypes, defined ''common'' or ''pure'', depending on the presence of senile changes exceeding physiological aging, and it has been suggested that such pathological differences may contribute to other features than cognitive impairment, such as behavioural and motor symptoms. [16].…”

Section: Discussionmentioning

confidence: 99%

Fluctuating cognition and different cognitive and behavioural profiles in Parkinson’s disease with dementia: comparison of dementia with Lewy bodies and Alzheimer’s disease

et al. 2010

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To examine the occurrence of fluctuating cognition (FC) in a group of patients with Parkinson's disease with dementia (PDD), and to determine whether the presence of FC in PDD is associated with a pattern of cognitive and behavioural disturbances similar to the one shown by patients affected by dementia with Lewy bodies (DLB), a cluster analysis was carried out on the scores obtained by 27 PDD patients on the Clinician Assessment of Fluctuation Scale (CAF). The analysis separated the PDD patients into two subgroups, called PDD non-fluctuators (PDDNF; CAF 2). The two groups underwent a cognitive and behavioural evaluation. Their scores were compared with those obtained by DLB and Alzheimer's disease (AD) patients. When exploring the cognitive performance of the patients with the Dementia Rating Scale-2 (DRS-2), PDDF had a similar pattern of impairments compared to DLB, which involved prevalently the attention and initiation/perseveration domains, and which was significantly more pronounced compared to that shown by PDDNF. The main behavioural finding of the study was the similar incidence of visual hallucinations in the PDDF and DLB groups, which was significantly higher compared to PDDNF and AD. Our results confirmed the hypothesis that subgroups with different cognitive profiles exist within PDD and that the occurrence of FC is the clinical variable associated with a DLB pattern of impairment in PDD. In conclusion, our study suggests that when FC occurs in PDD this syndrome becomes clinically undistinguishable from DLB.

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Section: Discussionmentioning

confidence: 99%

Fluctuating cognition and different cognitive and behavioural profiles in Parkinson’s disease with dementia: comparison of dementia with Lewy bodies and Alzheimer’s disease

et al. 2010

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“…For example, PDD tends to affect younger patients than DLB [16] . Patients with DLB may have more executive dysfunction and psychiatric symptoms than patients with PDD [8] .…”

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confidence: 99%

Cognitive Impairment in Parkinson’s Disease and Dementia with Lewy Bodies: A Spectrum of Disease

Gross

Siderowf

Hurtig³

2007

Neurosignals

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Parkinson’s disease (PD) is classically thought of as a movement disorder characterized by tremor, rigidity and postural instability. Nevertheless, there is growing recognition of prominent cognitive impairment in PD and related disorders, which is responsible for substantial disability in these patients. This review will focus on cognitive impairment associated with Lewy body pathology, including PD with dementia (PDD) and dementia with Lewy bodies (DLB). We will review the epidemiology, clinical evaluation, underlying mechanisms and treatment of cognitive impairment in these patients. Despite differences between PDD and DLB, there is clinical, neuropathological and radiological overlap between these disorders, supporting the view that they represent a spectrum of disease. These observations suggest that common targets for diagnosis and treatment of these disorders can be identified.

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“…DLB is characterized by cell loss and Lewy body deposition in brain stem nuclei (e.g., substantia nigra, locus ceuruleus) as in Parkinson’s disease (PD), and by diffuse deposition of Lewy bodies in limbic regions (e.g., hippocampus, amygdala) and the neocortex (Harding and Holliday, 2001). Concomitant AD pathology (i.e., neuritic plaques, neurofibrillary tangles) is also frequently present in a typical limbic/neocortical distribution (Hansen et al , 1993; Harding and Holliday, 2001; Horimoto et al , 2003; Tsuboi and Dickson, 2005). …”

Section: Introductionmentioning

confidence: 99%

Recognition memory span in autopsy-confirmed Dementia with Lewy Bodies and Alzheimer's Disease

et al. 2015

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Evidence from patients with amnesia suggests that recognition memory span tasks engage both long-term memory (i.e., secondary memory) processes mediated by the diencephalic-medial temporal lobe memory system and working memory processes mediated by fronto-striatal systems. Thus, the recognition memory span task may be particularly effective for detecting memory deficits in disorders that disrupt both memory systems. The presence of unique pathology in fronto-striatal circuits in Dementia with Lewy Bodies (DLB) compared to AD suggests that performance on the recognition memory span task might be differentially affected in the two disorders even though they have quantitatively similar deficits in secondary memory. In the present study, patients with autopsy-confirmed DLB or AD, and normal control (NC) participants, were tested on separate recognition memory span tasks that required them to retain increasing amounts of verbal, spatial, or visual object (i.e., faces) information across trials. Results showed that recognition memory spans for verbal and spatial stimuli, but not face stimuli, were lower in patients with DLB than in those with AD, and more impaired relative to NC performance. This was despite similar deficits in the two patient groups on independent measures of secondary memory such as the total number of words recalled from Long-Term Storage on the Buschke Selective Reminding Test. The disproportionate vulnerability of recognition memory span task performance in DLB compared to AD may be due to greater fronto-striatal involvement in DLB and a corresponding decrement in cooperative interaction between working memory and secondary memory processes. Assessment of recognition memory span may contribute to the ability to distinguish between DLB and AD relatively early in the course of disease.

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Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia

Cited by 35 publications

References 14 publications

Fluctuating cognition and different cognitive and behavioural profiles in Parkinson’s disease with dementia: comparison of dementia with Lewy bodies and Alzheimer’s disease

Fluctuating cognition and different cognitive and behavioural profiles in Parkinson’s disease with dementia: comparison of dementia with Lewy bodies and Alzheimer’s disease

Cognitive Impairment in Parkinson’s Disease and Dementia with Lewy Bodies: A Spectrum of Disease

Recognition memory span in autopsy-confirmed Dementia with Lewy Bodies and Alzheimer's Disease

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