Cognitive complaints in Parkinson’s disease patients: from subjective cognitive complaints to dementia and affective disorders

Barbosa, Raquel; Mendonça, M.; Caetano, André; Lampreia, Tânia; Miguel, Rita; Bugalho, Paulo

doi:10.1007/s00702-019-02042-8

Cited by 25 publications

(56 citation statements)

References 27 publications

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“…For the same reasons, we reported a higher SCC prevalence of 28.1% in our cognitively normal participants. In non-early PD cohorts, SCC prevalence ranged from 16 to 85%, due to varying SCC assessment methods and inclusion of participants with greater severity of cognitive impairment or disease [4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Exclusion criteria were history of stroke, active malignancy, significant orthopaedic abnormalities, end-organ failure, neurological or psychiatric conditions. [3,4]. NMSS Domain-5 comprises three questions that assesses memory, attention, and functional impact.…”

Section: Participantsmentioning

confidence: 99%

“…In non-early PD cohorts, depressive symptoms have been linked to increased reporting of SCC [5], and conversely, SCC presence was more tightly associated with depressive symptoms rather than cognition [4]. Another study in non-early PD patients showed that SCC in cognitively normal patients was related to anxiety but not depression [6].…”

Section: Introductionmentioning

confidence: 99%

“…Subjective cognitive complaints (SCC) is a concern of persistent cognitive decline in any domain, with or without objective cognitive deficits [2]. SCC is highly prevalent in PD, ranging from 30.3% in early disease [3] to 85% in advanced disease [4], and may predict future Mild Cognitive Impairment (MCI). Nonetheless, there is no consensus operationalising SCC definition and assessment tools [2].…”

Section: Introductionmentioning

confidence: 99%

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Subjective cognitive Complaints in early Parkinson's disease patients with normal cognition are associated with affective symptoms

Chua

Koh

Chia

et al. 2021

Parkinsonism & Related Disorders

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Subjective cognitive complaints (SCC) and affective symptoms are highly prevalent in Parkinson's Disease (PD). In early PD, SCC prevalence and its affective correlates, using recommended Movement Disorders Society (MDS) Level II Criteria to define the underlying cognitive impairment, has not been previously explored. Methods: We recruited 121 participants with early PD from two tertiary hospitals in Singapore. The presence of SCC was defined using a Non-Motor Symptoms Scale Domain-5 Score ≥1. Comprehensive neuropsychological testing was conducted with Mild Cognitive Impairment (PD-MCI) defined using recommended MDS Level II Criteria. Affective symptoms were assessed using the Hospital Anxiety Depression Scale (HADS), Geriatric Depression Scale (GDS) and Apathy Scale (AS). Analysis using multivariable linear regression model was performed. Results: In our early PD cohort, SCC prevalence independent of underlying cognitive status was 38.8%. Prevalence of SCC in cognitively impaired and cognitively normal participants was 10.7% and 28.1% respectively (р = 0.241). In cognitively normal PD participants, multivariable linear regression analysis revealed that SCC was significantly associated with anxiety (β = 0.28, 95% CI = 0.09-0.79, p = 0.014), depression (β = 0.31, 95% CI = 0.10-0.59, p = 0.006) and apathy (β = 0.32, 95% CI = 1.15-5.98, p = 0.004). Such an association was not found in cognitively impaired PD participants. Conclusion: SCC is highly prevalent even in early PD. Its implications in early PD differ depending on underlying cognitive status. SCC in cognitively impaired participants underestimates the true prevalence of PD-MCI. In contrast, SCC in cognitively normal participants is suggestive of an underlying affective disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Subjective cognitive Complaints in early Parkinson's disease patients with normal cognition are associated with affective symptoms

Chua

Koh

Chia

et al. 2021

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

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“…5,6 The value of subjective cognitive complaint (SCC) and its relationship to objective cognitive decline in patients with PD without dementia is not well understood. Some studies, with sample sizes ranging from 70 to 250 participants, have shown that patients with PD with SCC perform significantly worse on objective cognitive measures than those without SCC, [7][8][9][10][11][12][13] whereas others have not. 14,15 Only 4 of the studies reported longitudinal follow-up data to examine the conversion of nondemented patients with PD to PD-MCI or PD with dementia; 2 of these studies found higher rates of conversion from normal cognition to PD-MCI during a 2 to 2.5-year period in patients with PD with SCCs.…”

mentioning

confidence: 99%

Subjective Cognitive Complaint in Parkinson's Disease Patients With Normal Cognition: Canary in the Coal Mine?

et al. 2020

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Objective The objective of this study was to determine the frequency and impact of subjective cognitive complaint (SCC) in Parkinson's disease (PD) patients with normal cognition. Methods Patients with PD with expert consensus‐determined normal cognition at baseline were asked a single question regarding the presence of SCC. Baseline (N = 153) and longitudinal (up to 4 follow‐up visits during a 5‐year period; N = 121) between‐group differences in patients with PD with (+SCC) and without (−SCC) cognitive complaint were examined, including cognitive test performance and self‐rated and informant‐rated functional abilities. Results A total of 81 (53%) participants reported a cognitive complaint. There were no between‐group differences in global cognition at baseline. Longitudinally, the +SCC group declined more than the −SCC group on global cognition (Mattis Dementia Rating Scale–2 total score, F1,431 = 5.71, P = 0.02), processing speed (Symbol Digit Modalities Test, F1,425 = 7.52, P = 0.006), and executive function (Trail Making Test Part B, F1,419 = 4.48, P = 0.04), although the results were not significant after correction for multiple testing. In addition, the +SCC group was more likely to progress to a diagnosis of cognitive impairment over time (hazard ratio = 2.61, P = 0.02). The +SCC group also demonstrated significantly lower self‐reported and knowledgeable informant–reported cognition‐related functional abilities at baseline, and declined more on an assessment of global functional abilities longitudinally. Conclusions Patients with PD with normal cognition, but with SCC, report poorer cognition‐specific functional abilities, and are more likely to be diagnosed with cognitive impairment and experience global functional ability decline long term. These findings suggest that SCC and worse cognition‐related functional abilities may be sensitive indicators of initial cognitive decline in PD. © 2020 International Parkinson and Movement Disorder Society

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Disease progression in Parkinson‘s disease patients with subjective cognitive complaint

Liang

Wang

et al. 2021

Ann Clin Transl Neurol

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Objective Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI). Methods A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD. Results At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p < 0.05). Longitudinal analyses revealed that the PD‐SCC group exhibited faster progression in terms of BDI scores (p = 0.042) and PDQ‐39 scores (p = 0.035) than the PD‐NC group. The PD‐MCI group exhibited faster progression rates in the Epworth Sleepiness Scale scores (p = 0.001) and PDQ‐39 scores (p = 0.005) than the PD‐NC group. In addition, the PD‐SCC group exhibited a greater reduction in attention (Trail Making Test Part A, p = 0.047) and executive function (Stroop Color‐Word Test, p = 0.037) than the PD‐NC group. Interpretation PD‐SCC patients exhibited faster deterioration of depression and QoL than PD‐NC patients, and SCC may be an indicator of initial attention and executive function decline in PD. Our findings provided a more accurate prognosis in PD‐SCC patients.

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Cognitive complaints in Parkinson’s disease patients: from subjective cognitive complaints to dementia and affective disorders

Cited by 25 publications

References 27 publications

Subjective cognitive Complaints in early Parkinson's disease patients with normal cognition are associated with affective symptoms

Subjective cognitive Complaints in early Parkinson's disease patients with normal cognition are associated with affective symptoms

Subjective Cognitive Complaint in Parkinson's Disease Patients With Normal Cognition: Canary in the Coal Mine?

Disease progression in Parkinson‘s disease patients with subjective cognitive complaint

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