Cognitive compensation failure in multiple sclerosis

Bonnet, Mélissa C.; Allard, Michèle; Dilharreguy, Bixente; Deloire, Mathilde; Petry, Klaus G.; Brochet, Bruno

doi:10.1212/wnl.0b013e3181f612e3

Cited by 69 publications

(59 citation statements)

References 26 publications

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“…The mechanisms by which cerebellar damage could be associated with IPS impairment have been suggested by several fMRI studies 19–21. In early RRMS, when patients showed normal performances in the easiest levels of the tasks and significantly longer reaction times (slow IPS) during the most demanding cognitive conditions, shorter reaction times were not associated with higher cerebellar activation but with an increase in medial prefrontal activation instead and the functional connectivity analysis showed a functional link between the dorsolateral prefrontal cortex and medial prefrontal regions but not with the cerebellum 19. These results suggest that patients with MS are unable to activate the typical cerebellofrontal network associated with the fastest responses in the task and that they activate a substitute compensatory network involving the medial prefrontal cortex.…”

Section: Discussionmentioning

confidence: 89%

Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis

Moroso

Ruet

Lamargue-Hamel

et al. 2016

J Neurol Neurosurg Psychiatry

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Section: Discussionmentioning

confidence: 89%

Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis

Moroso

Ruet

Lamargue-Hamel

et al. 2016

J Neurol Neurosurg Psychiatry

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“…Functional MRI studies have found increased activity during PASAT performance in MS (Bonnet et al, 2010, Chiaravalloti et al, 2015, Ksiazek-Winiarek et al, 2015, Morgen et al, 2007, Rocca et al, 2016). Indeed, Morgen et al (2007) found that low PASAT scores correlated with reduction of activation of anterior cingulate cortex, but also with enlarged activation of frontoparietal regions and more widely distributed cortical recruitment as an effort to maintain cognitive functioning.…”

Section: Discussionmentioning

confidence: 99%

“…Modifications of the cerebral architecture could be integral mechanisms to maintain optimal network functioning or reflect maladaptive changes promoting clinical dysfunction. Altogether, longitudinal studies are needed to understand the positive or deleterious consequences of brain reorganization (Bonnet et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

Structural networks involved in attention and executive functions in multiple sclerosis

Llufriú

Martínez‐Heras

Solana

et al. 2017

NeuroImage: Clinical

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Attention and executive deficits are disabling symptoms in multiple sclerosis (MS) that have been related to disconnection mechanisms. We aimed to investigate changes in structural connectivity in MS and their association with attention and executive performance applying an improved framework that combines high order probabilistic tractography and anatomical exclusion criteria postprocessing. We compared graph theory metrics of structural networks and fractional anisotropy (FA) of white matter (WM) connections or edges between 72 MS subjects and 38 healthy volunteers (HV) and assessed their correlation with cognition. Patients displayed decreased network transitivity, global efficiency and increased path length compared with HV (p < 0.05, corrected). Also, nodal strength was decreased in 26 of 84 gray matter regions. The distribution of nodes with stronger connections or hubs of the network was similar among groups except for the right pallidum and left insula, which became hubs in patients. MS subjects presented reduced edge FA widespread in the network, while FA was increased in 24 connections (p < 0.05, corrected). Decreased integrity of frontoparietal networks, deep gray nuclei and insula correlated with worse attention and executive performance (r between 0.38 and 0.55, p < 0.05, corrected). Contrarily, higher strength in the right transverse temporal cortex and increased FA of several connections (mainly from cingulate, frontal and occipital cortices) were associated with worse functioning (r between − 0.40 and − 0.47, p < 0.05 corrected). In conclusion, structural brain connectivity is disturbed in MS due to widespread impairment of WM connections and gray matter structures. The increased edge connectivity suggests the presence of reorganization mechanisms at the structural level. Importantly, attention and executive performance relates to frontoparietal networks, deep gray nuclei and insula. These results support the relevance of network integrity to maintain optimal cognitive skills.

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“…Brain reorganization has also been observed in CIS patients when performing cognitive [12] and motor tasks [13]. To better characterize differences in the patterns of brain activations between MS patients and HC, a few studies have also analyzed functional/effective connectivity among different brain regions [14,15,16,17,18]. However, only a seminal study has shown an increased connectivity of brain regions of the working memory network in CIS compared to HC [19].…”

mentioning

confidence: 99%

Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study

et al. 2011

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Abstract:Objective. To assess whether abnormalities on functional magnetic resonance imaging (fMRI) are related to cognitive function in patients at presentation with clinically isolated syndrome (CIS) suggestive of MS. Methods. Eighteen CIS patients and 15 healthy controls (HC) performed an adapted fMRI version of the Paced Auditory Serial http://mc.manuscriptcentral.com/multiple-sclerosis Multiple Sclerosis Journal F o r P e e r R e v i e w Addition Test (PASAT). According to their PASAT performance, CIS patients were divided into two groups: 10 with a low PASAT performance (< 1SD from the mean value of HC) were considered "cognitive impairment" (CI); 8 patients were defined as "cognitively preserved" (CP). Between-group differences in the patterns of brain activations and effective connectivity were assessed. Results. During PASAT, compared to HC, CIS patients showed increased activations of the bilateral inferior parietal lobe (IPL), bilateral precuneus, bilateral middle frontal gyrus (MFG), left anterior cingulate cortex (ACC), left claustrum, right thalamus and right caudate nucleus. When CIS patients were analyzed, the CI group had a more significant activation of the bilateral IPL than HC and CP patients. Compared to CP patients, they also had more significant recruitment of the right superior parietal lobe, right cerebellum, left MFG and left ACC. The analysis of effective connectivity showed stronger connections between several regions of the right hemisphere involved in working memory function in CI patients vs. CP and HC. Conclusions. The observed differences in the patterns of cortical recruitment and connectivity in CI patients during PASAT performance are likely to be adaptive and have a role in limiting cognitive dysfunctions early in the course of MS. Methods. Eighteen CIS patients and 15 healthy controls (HC) performed an adapted fMRI version of the Paced Auditory Serial Addition Test (PASAT). According to their PASAT performance, CIS patients were divided into two groups: 10 with a low PASAT performance (< 1SD from the mean value of HC) were considered "cognitive impairment"(CI); 8 patients were defined as "cognitively preserved" (CP). Between-group differences in the patterns of brain activations and effective connectivity were assessed. Conclusions. The observed differences in the patterns of cortical recruitment and connectivity in CI patients during PASAT performance are likely to be adaptive and have a role in limiting cognitive dysfunctions early in the course of MS.

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Cognitive compensation failure in multiple sclerosis

Cited by 69 publications

References 26 publications

Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis

Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis

Structural networks involved in attention and executive functions in multiple sclerosis

Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study

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