Cognitive changes after tDCS and escitalopram treatment in major depressive disorder: Results from the placebo-controlled ELECT-TDCS trial

Moreno, María Alejandra; Goerigk, Stephan; Bertola, Laiss; Suemoto, Cláudia Kimie; Razza, Laís B.; Moffa, Adriano H.; Veronezi, Beatriz P.; Tort, Luara C.; Nogueira, Barbara Schwair; Gattaz, Wagner F.; Fráguas, Renério; Padberg, Frank; Lotufo, Paulo A; Brunoni, André R.

doi:10.1016/j.jad.2019.12.009

Cited by 16 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This exploratory treatment has been tested widely for the treatment of major depressive disorder (MDD) [ 10 – 13 ]. Both clinical trials and systematic reviews with meta-analyses have shown that tDCS not only has the potential to improve mood symptoms in depressive patients [ 11 , 14 , 15 ] but is also able to enhance cognitive functions [ 16 – 18 ]. TDCS showed potential in patients with bipolar disorder in a major depressive episode [ 19 – 21 ] and postpartum depression [ 22 ], as well as in adult [ 23 , 24 ] and elderly [ 25 ] populations.…”

Section: Introductionmentioning

confidence: 99%

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Wang

Luo

Schülke

et al. 2021

BMC Med

View full text Add to dashboard Cite

Background Transcranial direct current stimulation (tDCS) has shown mixed results for depression treatment. The efficacies of tDCS combination therapies have not been investigated deliberately. This review aims to evaluate the clinical efficacy of tDCS as a monotherapy and in combination with medication, psychotherapy, and ECT for treating adult patients with major depressive disorder (MDD) and identified the factors influencing treatment outcome measures (i.e. depression score, dropout, response, and remission rates). Methods The systematic review was performed in PubMed/Medline, EMBASE, PsycINFO, Web of Sciences, and OpenGrey. Two authors performed independent literature screening and data extraction. The primary outcomes were the standardized mean difference (SMD) for continuous depression scores after treatment and odds ratio (OR) dropout rate; secondary outcomes included ORs for response and remission rates. Random effects models with 95% confidence intervals were employed in all outcomes. The overall effect of tDCS was investigated by meta-analysis. Sources of heterogeneity were explored via subgroup analyses, meta-regression, sensitivity analyses, and assessment of publication bias. Results Twelve randomised, sham-controlled trials (active group: N = 251, sham group: N = 204) were included. Overall, the integrated depression score of the active group after treatment was significantly lower than that of the sham group (g = − 0.442, p = 0.017), and further analysis showed that only tDCS + medication achieved a significant lower score (g = − 0.855, p < 0.001). Moreover, this combination achieved a significantly higher response rate than sham intervention (OR = 2.7, p = 0.006), while the response rate remained unchanged for the other three therapies. Dropout and remission rates were similar in the active and sham groups for each therapy and also for the overall intervention. The meta-regression results showed that current intensity is the only predictor for the response rate. None of publication bias was identified. Conclusion The effect size of tDCS treatment was obviously larger in depression score compared with sham stimulation. The tDCS combined selective serotonin re-uptake inhibitors is the optimized therapy that is effective on depression score and response rate. tDCS monotherapy and combined psychotherapy have no significant effects. The most important parameter for optimization in future trials is treatment strategy.

show abstract

Section: Introductionmentioning

confidence: 99%

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Wang

Luo

Schülke

et al. 2021

BMC Med

View full text Add to dashboard Cite

show abstract

“…For instance, Bennabi et al evaluated neuropsychological outcomes after an observational follow-up period of 30 days (Bennabi et al, 2015) and observed no differences between baseline and follow-up measures. Although tDCS appears to be cognitively safe in the acute treatment of depression (Martin et al, 2018;Moreno et al, 2020) and may actually improve cognitive performance in depressed patients after a course of the treatment (Salehinejad et al, 2015), its cognitive effects after long-term application are still unknown and future trials must be conducted in order to more accurately demonstrate these effects.…”

Section: Discussionmentioning

confidence: 99%

Follow-up effects of transcranial direct current stimulation (tDCS) for the major depressive episode: A systematic review and meta-analysis

Razza

Smet

Moffa

et al. 2021

Psychiatry Research

View full text Add to dashboard Cite

“…Among these configurations, bilateral DLPFC with the cathode on the right DLPFC (F4) is one of the most common montages. This tDCS montage has proven effective in treating depression (46)(47)(48), schizophrenia (49), addiction (50,51), ADHD (52), and anxiety (53). Notably, evidence suggests that alterations in FSPV interneurons may play a crucial role in the pathophysiology of these disorders (54)(55)(56).…”

Section: Introductionmentioning

confidence: 99%

Effect of transcranial direct current stimulation on the functionality of 40 Hz auditory steady state response brain network: graph theory approach

et al. 2023

View full text Add to dashboard Cite

IntroductionMeasuring whole-brain networks of the 40 Hz auditory steady state response (ASSR) is a promising approach to describe the after-effects of transcranial direct current stimulation (tDCS). The main objective of this study was to evaluate the effect of tDCS on the brain network of 40 Hz ASSR in healthy adult males using graph theory. The second objective was to identify a population in which tDCS effectively modulates the brain network of 40 Hz ASSR.MethodsThis study used a randomized, sham-controlled, double-blinded crossover approach. Twenty-five adult males (20–24 years old) completed two sessions at least 1 month apart. The participants underwent cathodal or sham tDCS of the dorsolateral prefrontal cortex, after which 40 Hz ASSR was measured using magnetoencephalography. After the signal sources were mapped onto the Desikan–Killiany brain atlas, the statistical relationships between localized activities were evaluated in terms of the debiased weighted phase lag index (dbWPLI). Weighted and undirected graphs were constructed for the tDCS and sham conditions based on the dbWPLI. Weighted characteristic path lengths and clustering coefficients were then measured and compared between the tDCS and sham conditions using mixed linear models.ResultsThe characteristic path length was significantly lower post-tDCS simulation (p = 0.04) than after sham stimulation. This indicates that after tDCS simulation, the whole-brain networks of 40 Hz ASSR show a significant functional integration. Simple linear regression showed a higher characteristic path length at baseline, which was associated with a larger reduction in characteristic path length after tDCS. Hence, a pronounced effect of tDCS is expected for those who have a less functionally integrated network of 40 Hz ASSR.DiscussionGiven that the healthy brain is functionally integrated, we conclude that tDCS could effectively normalize less functionally integrated brain networks rather than enhance functional integration.

show abstract

Cognitive changes after tDCS and escitalopram treatment in major depressive disorder: Results from the placebo-controlled ELECT-TDCS trial

Cited by 16 publications

References 50 publications

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Follow-up effects of transcranial direct current stimulation (tDCS) for the major depressive episode: A systematic review and meta-analysis

Effect of transcranial direct current stimulation on the functionality of 40 Hz auditory steady state response brain network: graph theory approach

Contact Info

Product

Resources

About