Cognitive changes after epilepsy surgery in the posterior cortex

Luerding, Ralf

doi:10.1136/jnnp.2003.014746

Cited by 32 publications

(17 citation statements)

References 16 publications

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“…33 They have shown that overall intelligence in these patients is usually below average. They have also found deficits in specific cognitive functions such as memory, attention and executive functions, in a large percentage of patients.…”

Section: Parietal Lobe Epilepsymentioning

confidence: 98%

Cognitive Disorders Associated with Epilepsy: Diagnosis and Treatment

Carreño

Donaire²,

Sánchez-Carpintero³

2008

The Neurologist

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The heterogeneity of different types of epilepsy makes case-control studies difficult; however, thanks to the growing interest in the neuropsychological deficits associated with epilepsy, we now know some factors that could lead to the appearance of these disorders and their prognosis. Special care must be taken to detect cognitive side effects associated with AEDs, which seem to be more common with classic than with new AEDs, and in those patients receiving polytherapy. Neuropsychological assessment should be routinely performed before epilepsy surgery to predict possible postsurgical cognitive deficits.

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Section: Parietal Lobe Epilepsymentioning

confidence: 98%

Cognitive Disorders Associated with Epilepsy: Diagnosis and Treatment

Carreño

Donaire²,

Sánchez-Carpintero³

2008

The Neurologist

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“…tion within posterior temporal-occipital-parietal areas for treatment of epilepsy resulted in a postoperative decline in nonverbal IQ, but not verbal IQ, as nonverbal skills rely to a greater degree on visual processes. 43 …”

Section: Deficits After Occipital and Parietal Lobe Resectionmentioning

confidence: 99%

Prediction of neuropsychological outcome after resection of temporal and extratemporal seizure foci

Dulay

Busch

2012

FOC

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Resection of seizure foci is an effective treatment for the control of medically intractable epilepsy. However, cognitive morbidity can occur as a result of surgical intervention. This morbidity is dependent on several factors, including location and extent of resection, disease characteristics, patient demographic characteristics, and functional status of the tissue to be resected. In this review article, the authors provide a summary of the neurocognitive outcomes of epilepsy surgery with an emphasis on presurgical predictors of postsurgical cognitive decline.

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“…With one category difference taken as a basis, declines were seen most often in language and memory functions. Luerding et al (2004) found no risk for a substantial decline in general cognition in adult patients with posterior resections. Opposite trends of slightly increasing verbal and slightly decreasing performance IQ led to a significant difference between verbal and performance IQ after surgery in that study.…”

Section: Discussionmentioning

confidence: 75%

Neuropsychological results in pediatric patients with epilepsy surgery in the parietal cortex

Gleißner¹,

Kuczaty²,

Clusmann

et al. 2007

Epilepsia

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SUMMARYThis study evaluated pre-and postoperatively cognitive functions in 15 pediatric patients with surgically treated parietal lobe epilepsy (PLE). Seizure outcome was very satisfying with 87% seizurefree patients 1 year after surgery, and 82% in the long-term follow-up. Preoperative intelligence was in the subaverage range. Impairments in specific cognitive functions (memory, attention, executive functions) were evident preoperatively for 39-66% of patients. Behavioral disorders were rare. No side differences (left versus right PLE) were indicated pre-or postoperatively. Postoperative improvements were found in behavior and attention; other cognitive functions were unchanged. All in all, this preliminary study indicated a satisfactory neuropsychological outcome in pediatric patients with PLE. KEY WORDS: Children, Epilepsy surgery, Neuropsychology, Parietal lobe epilepsy.The parietal lobes (PLs) account for approximately 25% of brain volume, but partial seizures of PL origin account for only 5% of all partial epilepsies (Rasmussen, 1987). Accurately localizing parietal lobe epilepsy (PLE) is often difficult because of its inconsistent semiologic features. Seizures in many parts of the PLs are functionally silent and may only appear after having spread to adjacent brain regions such as the post-or precentral gyrus or temporal lobe. Brain tumors are the most common cause of PLE (Salanova et al., 1995) and surgical treatment is frequently successful. However, the PLs contain highly eloquent areas and resection may lead to deficits in vision, language, praxis, attention, and higher cortical functions. The PL plays a crucial role in linking sensation to action. Lesion studies show that a wide range of sensorimotor functions can be disrupted in patients with PL damage including visual or tactile agnosia, apraxia, acalculia, agraphia, aphasia, impaired cross-modal matching, rightleft disorientation, contralateral neglect, and disorders of body image (Siegel, 2003). Very few studies evaluate neuropsychological patterns associated with PLE and

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Cognitive changes after epilepsy surgery in the posterior cortex

Cited by 32 publications

References 16 publications

Cognitive Disorders Associated with Epilepsy: Diagnosis and Treatment

Cognitive Disorders Associated with Epilepsy: Diagnosis and Treatment

Prediction of neuropsychological outcome after resection of temporal and extratemporal seizure foci

Neuropsychological results in pediatric patients with epilepsy surgery in the parietal cortex

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