Cognitive–behavioural therapy combined with music therapy for chronic fatigue following Epstein-Barr virus infection in adolescents: a feasibility study

Malik, Sadaf; Asprusten, Tarjei Tørre; Pedersen, Maria; Mangersnes, Julie; Trondalen, Gro; Roy, Betty Van; Skovlund, Eva; Wyller, Vegard Bruun

doi:10.1136/bmjpo-2019-000620

Cited by 2 publications

(10 citation statements)

References 41 publications

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“…25–86 Following the full text screening, five papers were deemed appropriate to include in the narrative synthesis (further details in figure 1). 13,87–90…”

Section: Resultsmentioning

confidence: 99%

“…However, they noted that the study was underpowered and recommended the trial should be treated as an exploratory study as sufficient power is needed to assess the effectiveness of this treatment modality. 13…”

Section: Resultsmentioning

confidence: 99%

“…14 13 Intervention: The intervention consisted of a 10-week mental training programme. The patients had one introductory session followed by nine individual therapy sessions (one per week) for 1.5 hours and related homework, combining elements from CBT and music therapy.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

“…The effectiveness of therapies for prolonged symptoms, such as fatigue, following infection with endemic viruses like EBV, have previously been investigated. 13,14 A recent mixed-methods systematic review of post-viral fatigue syndromes provides useful lessons that may guide the development of Long COVID support services. 14 However, to our knowledge, beyond the synthesis of interventions used to support patients with fatigue, there is no review of the wider array of non-pharmacological interventions for patients with symptoms such as dyspnoea or arthralgia, both common with Long COVID.…”

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confidence: 99%

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Non-pharmacological therapies for post-viral syndromes, including Long COVID: A systematic review

Chandan

Brown

Simms-Williams

et al. 2022

Preprint

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Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises evidence for the effectiveness of non-pharmacological treatments for symptoms of PVS. It also summarises the symptoms and health impacts of PVS in individuals recruited to studies evaluating treatments. Methods and findings: We conducted a systematic review to evaluate the effectiveness of non-pharmacological interventions for PVS, as compared to either standard care, alternative non-pharmacological therapy, or placebo. The outcomes of interest were changes in symptoms, exercise capacity, quality of life (including mental health and wellbeing), and work capability. We searched five databases (Embase, MEDLINE, PsycINFO, CINAHL, MedRxiv) for randomised controlled trials (RCTs) published between 1st January 2001 to 29th October 2021. We anticipated that there would be few RCTs specifically pertaining to Long COVID, so we also included observational studies only if they assessed interventions in individuals where the viral pathogen was SARS-COV-2. Relevant outcome data were extracted, study quality appraised using the Cochrane Risk of Bias tool, and the findings were synthesised narratively. Quantitative synthesis was not planned due to substantial heterogeneity between the studies. Overall, five studies of five different interventions (Pilates, music therapy, telerehabilitation, resistance exercise, neuromodulation) met the inclusion criteria. Aside from music-based intervention, all other selected interventions demonstrated some support in the management of PVS in some patients. Conclusions: In this study, we observed a lack of robust evidence evaluating non-pharmacological treatments for PVS, including Long COVID. Considering the prevalence of prolonged symptoms following acute viral infections, there is an urgent need for clinical trials evaluating the effectiveness and cost-effectiveness of non-pharmacological treatments for patients with PVS as well as what may work for certain sub-groups of patients with differential symptom presentation. Registration: The study protocol was registered with PROSPERO [CRD42021282074] in October 2021 and published in BMJ Open in 2022. Keywords: Post-viral syndromes, PVS, COVID-19, Long COVID, post-COVID-19 condition, post-acute sequelae of SARS-CoV-2 infection (PASC), rehabilitation, systematic review, non-pharmacological intervention

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“…25–86 Following the full text screening, five papers were deemed appropriate to include in the narrative synthesis (further details in figure 1). 13,87–90…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Non-pharmacological therapies for post-viral syndromes, including Long COVID: A systematic review

Chandan

Brown

Simms-Williams

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…A pilot trial of physical exercise, which compared two variations (aerobic and resistance training), within a multicomponent inpatient programme (including physiotherapy, occupational therapy and psychological therapy), found that both variations led to improvements in quality of life, but only aerobic training decreased fatigue severity (Gordon et al, 2010). Music therapy has been combined with CBT and has been found to be feasible and acceptable, with indications of favourable outcomes in adolescents with postinfectious chronic fatigue (Malik et al, 2020).…”

Section: Treatmentmentioning

confidence: 99%

Paediatric chronic fatigue syndrome: 25 year perspective

Loades

Crawley

Chalder

et al. 2020

Clin Child Psychol Psychiatry

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Over the lifetime of Clinical Child Psychology and Psychiatry, there has been considerable progress in understanding the epidemiology of Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis (ME) and some progress in testing treatment approaches. Twenty-five years ago, clinicians and researchers did not believe that CFS existed in primary school children, little was known about the experience of children, and there were no randomised controlled trials testing treatment approaches. In this review, major developments in epidemiology, knowledge about clinical presentations and correlates, impact of CFS and treatment approaches will be highlighted. We are clinicians and researchers working in specialist CFS services in the United Kingdom.CFS has been a defined diagnostic entity since 1991 (Sharpe et al., 1991). There are several different diagnostic frameworks for diagnosing CFS (Carruthers et al., 2011;Fukuda et al., 1994;NICE, 2007;Sharpe et al., 1991). All include ongoing, debilitating fatigue which is not secondary to another medical condition or to exertion. Concomitant symptoms include general malaise, headaches, muscle and joint pain, nausea, disrupted sleep, dizziness and cognitive difficulties. Initially, the diagnostic criteria for adults were applied to children and young people. In 2004, the Royal College of Paediatrics and Child Health (RCPCH, 2004) recommended that fatigue lasting > 3 months was sufficient, a shorter duration than is required for adults. This has been reflected in some but not all the diagnostic frameworks. Here, we predominantly draw on evidence from clinical cohorts with a confirmed CFS diagnosis and evidence from general population studies of chronic debilitating fatigue, not necessarily formally assessed and diagnosed CFS. Changes in epidemiologyTwenty-five years ago, we did not know how common CFS was in teenagers, and whether it even existed in primary school aged children. The evidence base for the prevalence, incidence, and risk factors in paediatric CFS has since developed considerably.A recent systematic review and meta-analysis of prevalence studies found six studies in children and adolescents, with an estimated prevalence of 0.89% although there was considerable

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Cognitive–behavioural therapy combined with music therapy for chronic fatigue following Epstein-Barr virus infection in adolescents: a feasibility study

Cited by 2 publications

References 41 publications

Non-pharmacological therapies for post-viral syndromes, including Long COVID: A systematic review

Non-pharmacological therapies for post-viral syndromes, including Long COVID: A systematic review

Paediatric chronic fatigue syndrome: 25 year perspective

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