Cognitive behavioral therapy for depression in Japanese Parkinson&amp;#39;s disease patients: a pilot study

Shinmei, Issei; Kobayashi, Kei; Oe, Yuki; Takagishi, Yukihiro; Kanie, Ayako; Ito, Masaya; Takebayashi, Yoshitake; Murata, Miho; Horikoshi, Masaru; Dobkin, Roseanne D.

doi:10.2147/ndt.s104777

Cited by 19 publications

(15 citation statements)

References 50 publications

(66 reference statements)

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“… 1 , 2 In the People’s Republic of China, non-pharmacological treatments such as the psychotherapy are still not widely available, partly owing to the differences in culture and socioeconomic structures. 3 Although the effectiveness of CBT for depression on depression symptoms and anxiety symptoms had been found, 4 , 5 few studies have been conducted to explore the effectiveness of CBT for depression on insomnia and quality of life (QOL). Therefore, this study sought to examine the effects of CBT for depression on insomnia and QOL.…”

Section: Introductionmentioning

confidence: 99%

Effects of cognitive behavioral therapy for depression on improving insomnia and quality of life in Chinese women with breast cancer: results of a randomized, controlled, multicenter trial

Qiu¹,

Ren²,

Yang³

et al. 2018

NDT

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PurposeCognitive behavioral therapy (CBT) for depression had been found to be effective in reducing depressive and anxiety symptoms in breast cancer survivors. It is not known whether CBT for depression would also improve insomnia and quality of life (QOL). The aim of this study was to investigate whether CBT for depression would improve insomnia and QOL in a randomized controlled multicenter trial.Patients and methodsIn this study, breast cancer survivors (n=392) were randomly allocated to the following three groups: CBT (n=98), self-care management (SCM, n=98), and usual care (UC, n=196) in a ratio of 1:1:2. CBT and SCM received a series of nine sessions for 12 weeks, whereas UC received UC only. Insomnia and QOL were evaluated using Athens Insomnia Scale (AIS) and Functional Assessment of Cancer Therapy-Breast (FACT-B) questionnaire at baseline, 4, 12, and 24 weeks.ResultsThere was a significant intergroup difference in AIS and FACT-B scores (both P<0.01). CBT showed less insomnia problems and better overall QOL compared with those in SCM and UC (both P<0.01). No significant differences were found between SCM and UC in insomnia problems and overall QOL. Moreover, the effects of CBT on insomnia and QOL were maintained during the follow-up period.ConclusionCBT for depression can be effective in improving insomnia problems and QOL in the Chinese breast cancer survivors.

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Section: Introductionmentioning

confidence: 99%

Effects of cognitive behavioral therapy for depression on improving insomnia and quality of life in Chinese women with breast cancer: results of a randomized, controlled, multicenter trial

Qiu¹,

Ren²,

Yang³

et al. 2018

NDT

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“…The uncontrolled study recruited between 4 and 19 patients of similar age and disease duration to the controlled studies (table 1). Therapy duration ranged from 6 to 14 weeks and some studies adapted its content to limitations and problems specific to PD patients 33. The uncontrolled studies also reported significant improvement in depressive and anxiety at therapy end and follow-up (two studies followed participants at 4 weeks30 32 and one at 24 weeks33).…”

Section: Resultsmentioning

confidence: 99%

“…Therapy duration ranged from 6 to 14 weeks and some studies adapted its content to limitations and problems specific to PD patients 33. The uncontrolled studies also reported significant improvement in depressive and anxiety at therapy end and follow-up (two studies followed participants at 4 weeks30 32 and one at 24 weeks33). The two case series (three and five patients) also reported significant improvement for depressive symptoms,34 35 particularly for those with more severe depression at baseline 34…”

Section: Resultsmentioning

confidence: 99%

Cognitive–behavioural therapy for non-motor symptoms of Parkinson's disease: a clinical review

Koychev

Okai

2017

Evid Based Mental Health

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Neuropsychiatric symptoms are common in Parkinson's disease (PD) and have a disproportionate impact on quality of life and carer burden. Pharmacological treatment is the main approach in dealing with these symptoms, but it is limited by variable efficacy and risk of drug interactions. Non-pharmacological approaches using the cognitive-behavioural therapy (CBT) model are viable alternatives and in this review paper we summarise the evidence of CBT for three of the most common psychiatric manifestations of PD: depression and anxiety, impulse-control disorders and insomnia. Most studies modified the usual CBT format to include modules accounting for problems specific to PD: activity scheduling around motoric function, motor symptoms as triggers of anxiety, fear of falling and preparation for disease progression as well as accommodation of materials for suspected executive dysfunction. We found a growing evidence base that CBT (modified to account for PD-specific problems) is effective in the treatment of PD psychiatric symptoms. Where controlled study design was used, moderate effect sizes are reported for the efficacy of CBT for depression, including with distance administration of CBT. The effects were sustained during follow-up which was between 1 and 6 months. In addition, there are some initial data on the effects of CBT on impulse-control disorders and insomnia. The studies were limited by their small and potentially unrepresentative samples and the quality of sample reporting (eg, concomitant antidepressant and dopaminergic therapy use). Additional welldesigned and adequately powered studies are required to determine the utility of CBT in PD. INTRODUCTIONParkinson's disease (PD) is classically defined by a triad of motor symptoms (tremor, rigidity and bradykinesia). It is, however, increasingly conceptualised as a neuropsychiatric disorder 1 in view of the high prevalence of psychiatric features, including depression, impulse control disorders (ICD) and sleep difficulties.2 These non-motor complications are better predictors of disability, distress and rates to institutionalisation than the motor symptoms.3 Of the non-motor complications, mixed depression and anxiety is the most common psychiatric comorbidity, affecting ∼50% of PD patients, significantly more common that rates in the general population.4 Depression and anxiety are the strongest predictors of poorer quality of life, 5 even in the advanced stages of the illness where the motor features have progressed fully.6 ICD are characterised by repetitive, reward-based behaviours, linked to the dopaminergic medication used to treat the motor symptoms. They affect ∼14% of all PD patients 7 and are associated with psychiatric comorbidity and high carer burden.8 Sleep disturbance is another neuropsychiatric symptom that affects up to 60% of all PD patients.9 It is associated with somnolence 10 and impairment in attention and executive function.11 On the basis of their impact on quality of life and outcome, the recognition and treatment of neuropsych...

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“…It seems that by managing depression in the PD population, we can prevent additional syndrome, such as fear of falling. Cognitive-behavioral therapy showed satisfactory effects to control the FoF [54] and depression [52,[54][55][56] in PD, which needs further study. Furthermore, we suggest that researchers consider the level of depression while investigating the mechanism of FoF in participants with PD.…”

Section: The Effects Of the Threatening Conditions On Postural Stratementioning

confidence: 92%

A new postural stability-indicator to predict the level of fear of falling in Parkinson’s disease patients

et al. 2020

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Background: Fear of falling (FoF) is defined as a lasting concern about falling that causes a person to limit or even stop the daily activities that he/she is capable of. Seventy percent of Parkinson's disease (PD) patients report activity limitations due to FoF. Timely identification of FoF is critical to prevent its additional adverse effects on the quality of life. Self-report questionnaires are commonly used to evaluate the FoF, which may be prone to human error. Objectives: In this study, we attempted to identify a new postural stability-indicator to objectively predict the intensity of FoF and its related behavior(s) in PD patients. Methods: Thirty-eight PD patients participated in the study (mean age, 61.2 years), among whom 10 (26.32%) were identified with low FoF and the rest (73.68%) with high FoF, based on Falls Efficacy Scale-International (FES-I). We used a limit of stability task calibrated to each individual and investigated the postural strategies to predict the intensity of FoF. New parameters (FTR i s; functional time ratio) were extracted based on the center of pressure presence pattern in different rectangular areas (i = 1, 2, and 3). The task was performed on two heights to investigate FoF-related behavior(s). Results: FTR 1/2 (the ratio between FTR 1 and FTR 2) was strongly correlated with the FES-I (r = − 0.63, p < 0.001), Pull test (r = − 0.65, p < 0.001), Timed Up and Go test (r = − 0.57, p < 0.001), and Berg Balance Scale (r = 0.62, p < 0.001). The model of FTR 1/2 was identified as a best-fitting model to predicting the intensity of FoF in PD participants (sensitivity = 96.43%, specificity = 80%), using a threshold level of ≤ 2.83. Conclusions: Using the proposed assessment technique, we can accurately predict the intensity of FoF in PD patients. Also, the FTR 1/2 index can be potentially considered as a mechanical biomarker to sense the FoF-related postural instability in PD patients.

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Cognitive behavioral therapy for depression in Japanese Parkinson's disease patients: a pilot study

Cited by 19 publications

References 50 publications

Effects of cognitive behavioral therapy for depression on improving insomnia and quality of life in Chinese women with breast cancer: results of a randomized, controlled, multicenter trial

Effects of cognitive behavioral therapy for depression on improving insomnia and quality of life in Chinese women with breast cancer: results of a randomized, controlled, multicenter trial

Cognitive–behavioural therapy for non-motor symptoms of Parkinson's disease: a clinical review

A new postural stability-indicator to predict the level of fear of falling in Parkinson’s disease patients

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