Cognitive-Behavioral Stress Management Reduces Serum Cortisol By Enhancing Benefit Finding Among Women Being Treated for Early Stage Breast Cancer

Cruess, Dean G.; Antoni, Michael H.; McGregor, Bonnie A.; Kilbourn, Kristin; Boyers, A.; Alferi, Susan M.; Carver, Charles S.; Kumar, Mahendra

doi:10.1097/00006842-200005000-00002

Cited by 259 publications

(173 citation statements)

References 21 publications

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“…Data suggest that patients with advanced disease undergoing chemotherapy are able to successfully implement problem-solving strategies that reduce the severity of symptoms. The results of this study extend the work of other investigators who have reported on the effectiveness of CBIs in decreasing the severity of specific symptoms (Oliver et al, 2001) and for patients with a single cancer site (Antoni et al, 2001;Cruess et al, 2000). The results of this study extend support for using CBIs to affect multiple symptoms in patients with advanced disease across tumor types.…”

Section: Discussionsupporting

confidence: 84%

“…However, most studies have been limited to testing the effectiveness of CBIs in reducing the severity of a particular symptom, such as fatigue or pain (Oliver, Kravitz, Kaplan, & Meyers, 2001;Quesnel et al), or in patients who present with a particular site of cancer, such as breast cancer, regardless of the stage of disease Cruess et al, 2000). The goal of this study was to evaluate the effectiveness of a CBI in decreasing overall symptom severity in patients with advanced cancer undergoing chemotherapy.…”

Section: Resultsmentioning

confidence: 99%

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A Cognitive Behavioral Intervention for Symptom Management in Patients With Advanced Cancer

Sherwood¹,

Given²,

Given³

et al. 2005

Oncology Nursing Forum

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Purpose/Objectives: To evaluate the effectiveness of a cognitive behavioral intervention in decreasing symptom severity in patients with advanced cancer undergoing chemotherapy.Design: Prospective, randomized clinical trial based on cognitive behavioral theory. Setting: Six urban cancer centers in the midwestern United States.Sample: 124 patients 21 years of age or older were recruited and randomized to receive conventional care or conventional care and an intervention. Participants were newly diagnosed with stage III, stage IV, or recurrent cancer (solid tumor or non-Hodgkin lymphoma), undergoing chemotherapy, cognitively intact, and able to read and speak English.Methods: Data were gathered via telephone interviews at baseline and 10 and 20 weeks after randomization. Nurses with experience in oncology delivered a five-contact, eight-week intervention aimed at teaching patients problem-solving techniques to affect symptom severity.

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Section: Discussionsupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

A Cognitive Behavioral Intervention for Symptom Management in Patients With Advanced Cancer

Sherwood¹,

Given²,

Given³

et al. 2005

Oncology Nursing Forum

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“…35 Furthermore, this difference between groups in cortisol appears to have been mediated by the difference between groups in benefit finding. Conceptually similar findings also emerged for testosterone.…”

Section: Psychosocial Interventionmentioning

confidence: 99%

Enhancing adaptation during treatment and the role of individual differences

Carver

2005

Cancer

Self Cite

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With increased effectiveness of medical treatment for cancer, greater attention has been directed to the quality of life of cancer patients and cancer survivors. Work on this topic is aimed at better understanding the determinants of quality of life and creating ways to optimize these outcomes. Insights from many disciplines inform this effort. For example, personality psychology suggests bases for naturally occurring differences in resilience but also suggests ways to enhance adaptation and promote greater resilience. The author's current work relies on a view of individuals as goal-seeking beings whose efforts toward desired outcomes are threatened by diagnosis and treatment of cancer. Some react to such adversity with increased efforts, others with a giving-up response. This difference promotes differences in emotional well being. The author's group is focused on enhancing adaptation and providing patients with skills for stress management that permit patients to remain engaged in the pursuits that form their lives. This stress-management intervention has reduced the prevalence of depression among breast cancer patients and has increased the extent to which they report positive sequelae from cancer. The latter effect also has been related to differential reduction in cortisol. Ongoing work is examining well being in longer term survivors, including the effects of this intervention and the possibility that the intervention will have positive consequences for physical health. Cancer 2005;104(11 Suppl):2602-7.

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“…standardized bed and wake-up times, avoidance of daytime napping, and correction of maladaptive beliefs about sleep). [116][117][118][119][120][121][122][123][124][125][126][127] Such interventions may limit the impact of stress on the immune response and may have direct effects on neuroendocrine-immune interactions. Indeed, psychological interventions such as cognitive-behavioral stress management and mindfulness-based stress reduction have been shown to alleviate psychological distress in breast cancer patients, while increasing lymphocyte proliferative responses and normalizing diurnal cortisol secretion.…”

Section: Therapeutic Ramificationsmentioning

confidence: 99%

Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer

Miller

Ancoli‐Israel

Bower

et al. 2008

JCO

513

406

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Patients with cancer experience a host of behavioral alterations that include depression, fatigue, sleep disturbances and cognitive dysfunction. These behavioral co-morbidities are apparent throughout the process of diagnosis and treatment for cancer and can persist well into the survivorship period. There is a rich literature describing potential consequences of behavioral co-morbidities in patients with cancer including impaired quality of life, reduced treatment adherence and increased diseaserelated morbidity and mortality. Medical complications of cancer and its treatment such as anemia, thyroid dysfunction, and the neurotoxicity of cancer chemotherapeutic agents account in part for these behavioral changes. Nevertheless, recent advances in the neurosciences and immunology/ oncology have revealed novel insights into additional pathophysiologic mechanisms that may significantly contribute to the development of cancer-related behavioral changes. Special attention has been focused on immunologic processes, specifically activation of innate immune inflammatory responses and their regulation by neuroendocrine pathways, which, in turn, impact central nervous system functions including neurotransmitter metabolism, neuropeptide function, sleep-wake cycles, regional brain activity and ultimately behavior. Further understanding of these immunological influences on the brain provides a novel conceptual framework for integrating the wide spectrum of behavioral alterations that occur in cancer patients and may reveal a more focused array of translational targets for therapeutic interventions and future research. Such developments warrant complementary advances in identification of cancer patients at risk as well as those currently suffering, including an increased emphasis on the status of behavior as a "sixth vital sign" to be assessed in all cancer patients throughout their disease encounter.

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Cognitive-Behavioral Stress Management Reduces Serum Cortisol By Enhancing Benefit Finding Among Women Being Treated for Early Stage Breast Cancer

Abstract: These findings suggest that positive growth enhanced during a time-limited intervention can influence physiological parameters such as cortisol among women with early stage breast cancer.

Cited by 259 publications

References 21 publications

A Cognitive Behavioral Intervention for Symptom Management in Patients With Advanced Cancer

A Cognitive Behavioral Intervention for Symptom Management in Patients With Advanced Cancer

Enhancing adaptation during treatment and the role of individual differences

Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer

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