Cognitive Assessment Tools Recommended in Geriatric Oncology Guidelines: A Rapid Review

Tuch, Gina; Soo, Wee Kheng; Luo, Ki Yung; Frearson, Kinglsey; Oh, Ek Leone; Phillips, Jane; Agar, Meera; Lane, Heather

doi:10.3390/curroncol28050339

Cited by 20 publications

(14 citation statements)

References 108 publications

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“…Patients with a score ≥ 50 at SAS were considered anxiety [ 19 ], while a score ≥ 53 at SDS suggests the presence of depressed [ 20 ]. And the Mini-mental Status Examination (MMSE) was evaluated to test cognitive function of subjects [ 21 ] too. In addition, the migraine patients’ disability was quantified using the Migraine Disability Assessment (MIDAS) [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Spatio-temporal dynamics of resting-state brain networks are associated with migraine disability

et al. 2023

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Objective The changes in resting-state functional networks and their correlations with clinical traits remain to be clarified in migraine. Here we aim to investigate the brain spatio-temporal dynamics of resting-state networks and their possible correlations with the clinical traits in migraine. Methods Twenty Four migraine patients without aura and 26 healthy controls (HC) were enrolled. Each included subject underwent a resting-state EEG and echo planar imaging examination. The disability of migraine patients was evaluated by Migraine Disability Assessment (MIDAS). After data acquisition, EEG microstates (Ms) combining functional connectivity (FC) analysis based on Schafer 400-seven network atlas were performed. Then, the correlation between obtained parameters and clinical traits was investigated. Results Compared with HC group, the brain temporal dynamics depicted by microstates showed significantly increased activity in functional networks involving MsB and decreased activity in functional networks involving MsD; The spatial dynamics were featured by decreased intra-network FC within the executive control network( ECN) and inter-network FC between dorsal attention network (DAN) and ECN (P < 0.05); Moreover, correlation analysis showed that the MIDAS score was positively correlated with the coverage and duration of MsC, and negatively correlated with the occurrence of MsA; The FC within default mode network (DMN), and the inter-FC of ECN- visual network (VN), ECN- limbic network, VN-limbic network was negatively correlated with MIDAS. However, the FC of DMN-ECN was positively correlated with MIDAS; Furthermore, significant interactions between the temporal and spatial dynamics were also obtained. Conclusions Our study confirmed the notion that altered spatio-temporal dynamics exist in migraine patients during resting-state. And the temporal dynamics, the spatial changes and the clinical traits such as migraine disability interact with each other. The spatio-temporal dynamics obtained from EEG microstate and fMRI FC analyses may be potential biomarkers for migraine and with a huge potential to change future clinical practice in migraine.

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Section: Methodsmentioning

confidence: 99%

Spatio-temporal dynamics of resting-state brain networks are associated with migraine disability

et al. 2023

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“…The Montreal Cognitive Assessment (MoCA) test was developed as a screening tool to detect the symptoms of mild cognitive impairment (MCI) [ 21 ]. The test is sensitive when applied to older adults with cancer [ 22 ] and is a recommended by the leading organizations in the field [ 14 , 20 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study

et al. 2022

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Cognitive function can be affected by cancer and/or its treatment, and older patients are at a particular risk. In a prospective observational study including patients ≥65 years referred for radiotherapy (RT), we aimed to investigate the association between patient- and cancer-related factors and cognitive function, as evaluated by the Montreal Cognitive Assessment (MoCA), and sought to identify groups with distinct MoCA trajectories. The MoCA was performed at baseline (T0), RT completion (T1), and 8 (T2) and 16 (T3) weeks later, with scores ranging between 0 and 30 and higher scores indicating better function. Linear regression and growth mixture models were estimated to assess associations and to identify groups with distinct MoCA trajectories, respectively. Among 298 patients with a mean age of 73.6 years (SD 6.3), the baseline mean MoCA score was 24.0 (SD 3.7). Compared to Norwegian norm data, 37.9% had cognitive impairment. Compromised cognition was independently associated with older age, lower education, and physical impairments. Four groups with distinct trajectories were identified: the very poor (6.4%), poor (8.1%), fair (37.9%), and good (47.7%) groups. The MoCA trajectories were mainly stable. We conclude that cognitive impairment was frequent but, for most patients, was not affected by RT. For older patients with cancer, and in particular for those with physical impairments, we recommend an assessment of cognitive function.

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“…Even subclinical cognitive changes could seriously disturbed patients' daily activities and many important aspects of their general well-being like medication adherence, comorbidity recognition and overall safety [13]. Majority of general practitioners noticed forgetfulness, decreased concentration, walking instability, thought slowness (symptoms of damage to small blood vessels in the brain) in 5% to 30% of their patients, while 5-20% of their patients complained on forgetfulness, mood swings, walking instability or a feeling of blurry mind themselves (Fig.…”

Section: Discussionmentioning

confidence: 99%

Recognition and treatment of mild cognitive impairment in Serbian general practice

2023

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Introduction/Objective. Mild cognitive impairment (MCI) is a state of progressive cognitive decline, rarely recognized by general practitioners (GPs), which is a reason of late treatment and fast progression towards more serious conditions. The main obstacles for the timely treatment of MCI are lack of diagnostic protocols and clinical guidelines as well as lack of knowledge and disbelief in the pharmacological therapeutic possibilities. The aim of this investigation was to assess level of recognition of MCI symptoms by general practitioners (GPs), and to estimate their perception of distinct risk factors significance for MCI development. Methods. Participants (general practitioners) of the ?Days of General Medicine? Conference (Serbia, March 2018), n = 340, completed 12 items questionnaire about recognition and treatment of the MCI patients. We have used descriptive statistics, Chi-square, Mann-Whitney U tests, binary logistic regression analysis for results presentation, sub-groups comparison, to assess predictors of drug therapy selection, respectively. Results. Study showed GPs recognize diabetes as most important factor for MCI, then hypercholesterolemia, smoking and sedentary behavior, while hypertension and obesity are perceived as less important. Those GPs who estimated diabetes and hypercholesterolemia as more important for all patients are significantly more prone to prescribe symptomatic therapy (pentoxifylline and vinpocetine), p < 0.05 according to Chi-square test. Logistic regression analysis regarding therapy predictions showed that years of GP experience is the most important predictor of drug therapy selection (p < 0.01). Conclusion. Results of this investigation pointed a need for MCI education for young physicians, in order to improve diagnosis and treatment of these patients.

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Cognitive Assessment Tools Recommended in Geriatric Oncology Guidelines: A Rapid Review

Cited by 20 publications

References 108 publications

Spatio-temporal dynamics of resting-state brain networks are associated with migraine disability

Spatio-temporal dynamics of resting-state brain networks are associated with migraine disability

Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study

Recognition and treatment of mild cognitive impairment in Serbian general practice

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