Cognitive and social-communication abilities among young children conceived by assisted reproductive technologies

Friedlander, Edwa; Mankuta, David; Yaari, Maya; Harel, Ayelet; Ebstein, Richard P.; Yirmiya, Nurit

doi:10.1080/17405629.2015.1115343

Cited by 1 publication

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relevant medical data regarding the mother (e.g., background medical conditions, chronic medication administration during pregnancy) and the neonate (e.g., gestational age at birth, birth weight) were obtained from computerized hospital records. Based on these data prenatal risk scores were calculated [Friedlander et al, ; Friedlander et al, ; Yaari et al, ]. This scale comprised the following variables, which each received 1 point if present: placental abruption, gestational age under 34 weeks, birth weight lower than 1,500 g, small size for gestational age—namely under the third percentile of Israeli growth curves, and Apgar score measured 5 min after birth ≤7.…”

Section: Methodsmentioning

confidence: 99%

Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development

et al. 2019

Self Cite

View full text Add to dashboard Cite

Compelling evidence for the far‐reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene–environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty‐three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk‐allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk‐allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087–1100. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD‐related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development.

show abstract

Section: Methodsmentioning

confidence: 99%