Cognitive and psychiatric changes as first clinical presentation in Sneddon syndrome

Fabiani, G; Filho, Raul Martins; Koppe, Gelson Luis; Demartini, Zeferino; Gatto, Luana Antunes Maranha

doi:10.1590/1980-57642018dn12-020016

Cited by 5 publications

(6 citation statements)

References 8 publications

(28 reference statements)

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“…Cerebral angiography, which has not been performed systemically in all reported cases, is usually normal [16]. However, Fabiani et al reported vasculitic changes in some patients [17].…”

Section: Central Nervous System Diseasesmentioning

confidence: 92%

Livedo racemosa in neurological diseases: an update on the differential diagnoses

Mitri

Enk

Bersano

et al. 2020

Euro J of Neurology

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Livedo is a net‐like violaceous skin pattern. It can be classified as physiological or pathological. The physiological livedo reticularis usually appears in cold conditions, whereas the pathological and irregular livedo, which persists in warm temperatures, is often labeled as ‘livedo racemosa’. Some neurological pathologies are associated with livedo, most commonly those with an inflammatory component or those derived from systemic disorders. The present review summarizes the most important central and peripheral neurological diseases in pediatric and adult age groups associated with livedo, providing physicians with an overview of the clinical presentation, etiology, diagnosis and management of these conditions.

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“…Cerebral angiography, which has not been performed systemically in all reported cases, is usually normal [16]. However, Fabiani et al reported vasculitic changes in some patients [17].…”

Section: Central Nervous System Diseasesmentioning

confidence: 92%

Livedo racemosa in neurological diseases: an update on the differential diagnoses

Mitri

Enk

Bersano

et al. 2020

Euro J of Neurology

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“…It is preceded in half of all cases by a transient cerebral accident 5 . Cognitive disorders are another hallmark of the disease, which justifies close neurological monitoring in any patient presenting with an isolated case of livedo racemosa 3 …”

Section: Discussionmentioning

confidence: 99%

“…Clinically, dementia is rarely inaugural in SS. It may simulate the Alzheimer's type of dementia, making the diagnosis more difficult 3 . Concentration, attention, memory, visual perception, and visuospatial construction are the most commonly described cognitive impairments 3 .…”

Section: Discussionmentioning

confidence: 99%

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Cognitive and psychiatric signs revealing Sneddon syndrome: A case report

Karoui,

Baklouti,

Ben Mohamed

et al. 2023

Clinical Case Reports

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Key Clinical MessageThe diagnosis of Sneddon Syndrome should be considered in adults with young‐onset dementia accompanied by neuropsychiatric signs and livedo racemosa. Magnetic resonance imaging and cerebral angiography are essential. A cutaneous biopsy may help in the diagnosis.AbstractSneddon syndrome (SS) is a clinical entity corresponding to a noninflammatory thrombotic vasculopathy that typically includes livedo racemosa and cerebrovascular ischemia. Psychiatric symptoms with cognitive impairment often occur but are rarely the inaugural symptoms. We present a case of secondary SS in a 45‐year‐old man in whom dementia and psychosis revealed the disease.

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“…Это может быть объяснено множественными церебральны-ми инфарктами [18,24]. Тем не менее, пациенты с синдромом Снеддона могут демонстрировать проявления деменции и без предшествующих случаев острого нарушения мозгового кровообращения [23,32,33]. Внутримозговые, внутрижелудочковые и субарахноидальные кровоизлияния не характерны для данного состояния, однако и геморрагические инсульты могут встречаться у пациентов с синдромом Снеддона.…”

Section: клиническая картина 1 сетчатое ливедоunclassified

A rare angiopathy with lesions of the skin and central nervous system: Sneddon syndrome and disease

Gruzmanov

Мазуренко

2022

Juvenis scientia

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Sneddon syndrome is a rare, progressive disease that affects relatively young people, mainly female, and manifests itself in two main symptoms: livedo reticularis and recurrent cerebral infarctions. First described in 1965 by the English dermatologist Ian Bruce Sneddon, the syndrome named in his honor unites a heterogeneous group of diseases with different pathogenesis and similar clinical manifestations. Skin manifestations of the disease in the form of reticular livedo are benign, cerebrovascular manifestations are reduced to repeated cerebral infarctions, progressive dementia and can lead to the death of patients. The literature review describes the basic concepts of the etiology, pathogenesis of primary and secondary forms of Sneddon syndrome, and proposes the concept of Sneddon’s disease to describe the primary forms of the syndrome. The article contains photographs of patients from the clinical practice of the authors of the article. The review also describes methods of diagnosis and differential diagnosis of the disease and recommended methods of treatment, which is based on the elimination of additional risk factors for vascular damage and thrombosis, blood pressure control, lipid and carbohydrate metabolism, as well as the appointment of anticoagulant and disaggregant therapy. The use of anti-inflammatory or immunosuppressive therapy remains controversial. The main goal of treatment is the prevention of organic brain damage and neuropsychiatric complications. Unfortunately, the neuropsychiatric prognosis of Sneddon syndrome is relatively poor with the development of impaired memory, concentration, and visual-spatial skills. In exceptional cases, the progression of the disease can lead to death.

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Cognitive and psychiatric changes as first clinical presentation in Sneddon syndrome

Cited by 5 publications

References 8 publications

Livedo racemosa in neurological diseases: an update on the differential diagnoses

Livedo racemosa in neurological diseases: an update on the differential diagnoses

Cognitive and psychiatric signs revealing Sneddon syndrome: A case report

A rare angiopathy with lesions of the skin and central nervous system: Sneddon syndrome and disease

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