Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia

Burton, Rachel; O’Connell, Megan E; Morgan, Debra

doi:10.1093/arclin/acx112

Cited by 26 publications

(37 citation statements)

References 66 publications

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“…Apathy manifests as a lack of motivation and interest, taking initiative, and goal-directed behavior. This may negatively influence a person’s ability to take initiative in participating in social contact with others, to perform self-care activities, as well as to find things to do without help from others [45]. Depressive symptoms were associated with a worse care relationship, lower positive affect, lower positive self-image, more negative affect, and more restless tense behavior.…”

Section: Discussionmentioning

confidence: 99%

Mood and behavioral problems are important predictors of quality of life of nursing home residents with moderate to severe dementia: A cross-sectional study

et al. 2019

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ObjectivesTo examine the predictors associated with quality of life of nursing home residents with dementia, in order to identify which predictors are most important and hold most promise for future intervention studies.Methods/DesignThis cross-sectional analysis of data collected in two intervention trials included 143 participants with moderate to severe dementia who resided in 40 psychogeriatric wards in 13 nursing homes. The outcome measure quality of life was assessed with the Qualidem. Predictors examined were demographic factors, cognition, mood, behavioral problems, and comorbid conditions.ResultsLinear mixed regression analyses showed that all nine domains of quality of life showed independent (negative) associations with either depression, agitation, apathy, or a combination of these predictors. Agitation, apathy, depression, and the presence of neurological disease explained 50% of the variance in total quality of life. Male gender, psychiatric/mood disorders, and having one or more comorbid conditions was associated with worse social relations, while the presence of comorbid neurological diseases was associated with more social isolation and a worse care relationship. The presence of endocrine/metabolic disorders and pulmonary disorders was associated with less restless tense behavior.ConclusionsDifferent domains of quality of life showed different associations, confirming the multidimensionality of quality of life in nursing home residents with dementia. Quality of life is independently associated with mood and behavioral problems, comorbid conditions, and gender. This knowledge may help to identify older persons at risk of a lower quality of life, and to offer targeted interventions to improve quality of life.Trial registrationDutch Trial registration NTR5641

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Section: Discussionmentioning

confidence: 99%

Mood and behavioral problems are important predictors of quality of life of nursing home residents with moderate to severe dementia: A cross-sectional study

et al. 2019

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“…For example, the Stroop test is used in exercise trials in these patient groups [ 18 , 19 , 20 , 21 ]. However, patients with dementia may have difficulty understanding and executing the task [ 22 ], which should be taken into account in the interpretation of the Stroop results. Furthermore, it should be noted that we assessed Flanker performance in subjects who participated in an exercise or control program for 6 months.…”

Section: Discussionmentioning

confidence: 99%

Psychometric Properties of a Flanker Task in a Sample of Patients with Dementia: A Pilot Study

Sanders

Hortobágyi

Balasingham

et al. 2018

Dement Geriatr Cogn Disord Extra

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Background/Aims: Reliable and valid neuropsychological tests for patients with dementia are scarce. To improve the assessment of attention and inhibitory control in dementia, we determined the feasibility, test-retest reliability, and validity of a Flanker task. Methods: Participants with all-cause diagnosed dementia (n = 22, mean age 84 years; mean Mini-Mental State Examination [MMSE] score = 19.4) performed a computerized Flanker task twice within 7 days. The Flanker task required participants to indicate the direction of target arrows flanked by congruent or incongruent arrows. Number of completed trials, accuracy, and reaction times (RTs) were recorded, and interference scores were calculated from basic scores. We examined the psychometric properties of the Flanker task and its relationship with the MMSE and Stroop test. Results: The Flanker task was feasible. Test-retest reliability was good for number of correct answers and RTs, and fair to poor for accuracy and the interference scores. The correlation of the Flanker task with Stroop and MMSE performance was fair to poor. Conclusion: The Flanker task appears to be feasible, and a reliable and valid measure of selective attention. Although the test-retest reliability for the Flanker RT interference measure was fair, future studies need to confirm its validity to measure inhibitory control in patients with dementia.

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“…Additionally, sleep disorders (nocturnal wakefulness) in AD patients were highly associated with anxiety levels (OR2.1) and ADL disorder (OR1.6) [ 12 ]. Apathy for normal and MCI participants was moderately associated with IADL [ 25 ]. Vascular dementia (VaD) patients’ level of apathy has also been reported as a predictor of BADL/IADL performance [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed that IADL independence declines and BPSD (apathy, depression) emerge from the MCI stage, and the association between the two has already been confirmed [ 23 , 24 , 25 ]. Additionally, studies have highlighted that MCI can lead to BPSD and a decline in IADL [ 14 , 25 ]. For example, it has also been shown that apathy is a predictor of complex ADL, especially in mild AD with a clinical dementia rating = 0.5 [ 26 ].…”

Section: Introductionmentioning

confidence: 93%

Association between Daily Activities and Behavioral and Psychological Symptoms of Dementia in Community-Dwelling Older Adults with Memory Complaints by Their Families

Ikeda

Han

Maruta

et al. 2020

IJERPH

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It is important and useful to consider information provided by family members about individuals with memory complaints’ instrumental activities of daily living (IADL). The purpose of this study was to clarify the characteristics and relevance of individuals with memory complaints’ IADL and behavioral and psychological symptoms of dementia (BPSD) assessed from the perspective of the family members using the Process Analysis of Daily Activity for Dementia and short version Dementia Behavior Disturbance scale. A self-administered questionnaire was sent to 2000 randomly selected members of Consumer’s Co-operative Kagoshima, and 621 responded. Of the returned responses, there were 159 participants who answered about individuals with memory complaints. The stepwise multiple regression analysis was used to examine the association between IADL and BPSD. The result showed that many IADL of the individuals with memory complaints were associated with BPSD of apathy, nocturnal wakefulness, and unwarranted accusations, adjusted for age, gender, and the observation list for early signs of dementia. In addition, each IADL was associated with BPSD of apathy, nocturnal wakefulness, and dresses inappropriately. Modifying lifestyle early on when families recognize these changes may help maintain and improve the long-term quality of life of the individuals with memory complaints and their family.

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Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia

Abstract: The implications for developing cognitive rehabilitation interventions are discussed, with a recommendation for interventions for symptoms of apathy.

Cited by 26 publications

References 66 publications

Mood and behavioral problems are important predictors of quality of life of nursing home residents with moderate to severe dementia: A cross-sectional study

Mood and behavioral problems are important predictors of quality of life of nursing home residents with moderate to severe dementia: A cross-sectional study

Psychometric Properties of a Flanker Task in a Sample of Patients with Dementia: A Pilot Study

Association between Daily Activities and Behavioral and Psychological Symptoms of Dementia in Community-Dwelling Older Adults with Memory Complaints by Their Families

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