Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies

Nagano‐Saito, Atsuko; Kato, Takashi; Arahata, Yutaka; Washimi, Yukihiko; Nakamura, Akinori; Abe, Yuji; Yamada, Takako; Iwai, Katsushige; Hatano, Kentaro; Kawasumi, Yasuhiro; Kachi, Teruhiko; Ito, Kengo

doi:10.1016/j.neuroimage.2004.01.030

Cited by 79 publications

(84 citation statements)

References 85 publications

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“…For example, the CBF (H 2 15 O) template provided within the SPM99 software was created with 12 normal scans. Most templates created for other brain tracers were obtained with a small number of subjects (i.e., 10215 subjects) (20,33,35,36). In our study, we used all of the validated normal images available in each center at the start of the research to create each template.…”

Section: Discussionmentioning

confidence: 99%

Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images

Kas¹,

Payoux²,

Habert³

et al. 2007

Journal of Nuclear Medicine

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(PD). Quantification of 123 I-FP-CIT images is performed at equilibrium using a ratio (BR) of specific (striatal) to nonspecific (occipital) uptake with values obtained from regions of interest drawn manually over these structures. Statistical parametric mapping (SPM) is a fully automated voxel-based statistical approach that has great potential in the context of DAT imaging. However, the accuracy of the spatial normalization provided by SPM has not been validated for 123 I-FP-CIT images. Our first aim was to create an 123 I-FP-CIT template that does not require the acquisition of patient-specific MRI and to validate the spatial normalization procedure. Next, we hypothesized that this customized template could be used by different SPECT centers without affecting the outcomes of imaging analyses. Methods: The spatial normalization to the customized template created with SPM (template A1) was validated using 123 I-FP-CIT images obtained from 6 subjects with essential tremor (ET) with normal DAT status and 6 PD patients. Variability in BR values due to the normalization was evaluated using striatal volume of interest (VOI). To determine whether different SPECT centers could use a unique 123 I-FP-CIT template, we generated 3 other 123 I-FP-CIT templates using different subjects and image-processing schemes. The interchangeability of these templates was assessed using (a) putamen BR values analyzed with the intraclass correlation coefficient (ICC) and the Bland-Altman graphical analysis, and (b) SPM analysis comparing the results of group comparisons-that is, ET versus PD, obtained after normalization to each of the 4 templates. Results: There was no significant difference between pre-and postnormalization striatal BR values in our study. The mean variability calculated with putamen VOI values after normalization to each template was ,10%, with the lowest ICC of 98%. Intergroup analyses performed with VOI and SPM approaches provided similar results independently of the template used. Conclusion: SPM normalization was accurate even in subjects with low striatal 123 I-FP-CIT uptake, making it a promising approach for automatic analysis of 123 I-FP-CIT images using a single customized template at different centers. Parki nson's disease (PD) is characterized by the progressive degeneration of nigrostriatal dopaminergic neurons. This neurodegenerative process is associated with a loss of striatal dopamine transporters (DATs) as shown by postmortem studies (1,2). Therefore, in vivo measurement of DAT density with PET or SPECT is an early marker of the dopaminergic cell loss in subjects with parkinsonian symptoms or in asymptomatic carriers of genetic mutations causing PD (3-7). In clinical routine, DAT SPECT images are often analyzed visually. However, quantitative analysis is useful to differentiate subjects with subtle localized or diffuse loss of DATs that can be difficult to sort out by visual inspection alone. Moreover, quantification is mandatory to measure disease progression (7-11) and to assess the efficacy of ne...

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Section: Discussionmentioning

confidence: 99%

Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images

Kas¹,

Payoux²,

Habert³

et al. 2007

Journal of Nuclear Medicine

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“…The parietal and occipital areas have also been found to be activated during motor tasks in patients with parkinsonism, suggesting a compensatory mechanism. 30 PET studies in PD have demonstrated a positive correlation between UPDRS and metabolic change in the primary motor cortex and supplementary motor areas, 31 and longitudinal studies have also revealed a progressive increase in the metabolic activity of subcortical structures and motor cortex. 32 A SPECT study that compared patients with DLB with and without parkinsonism found that those with parkinsonism had reduced blood flow in the primary and supplementary motor areas.…”

Section: Subject Demographicsmentioning

confidence: 99%

Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

et al. 2012

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Objective: To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging. Methods:The study included 106 subjects (35 with DLB, 36 with AD, and 35 elderly controls) who underwent clinical and neuropsychological assessment and diffusion tensor MRI. We used tract-based spatial statistics to investigate patterns of reduced fractional anisotropy (FA) and increased mean diffusivity (MD) across the entire white matter tract skeleton and also investigated correlations with clinical features. Results:Areas of reduced FA in subjects with DLB vs controls were found primarily in parietooccipital white matter tracts; in AD, the changes were much more diffuse. DLB was also associated with reduced FA in the pons and left thalamus, in comparison with AD. The pattern of MD increase was diffuse in AD and DLB. We found an association between DTI parameters and impaired episodic memory, letter fluency, and severity of motor parkinsonism in DLB. Conclusions:Despite a similar level of dementia severity, patterns of DTI changes in AD and DLB differed significantly. The selective involvement of the visual association areas and subcortical structures and the significant clinical correlations highlight the potential importance of white matter tract change in the pathogenesis of DLB. DTI may be a useful technique to investigate early and possible preclinical changes in DLB and warrants further investigation. Neurology Dementia with Lewy bodies (DLB) is a common form of neurodegenerative dementia in older people, second to Alzheimer disease (AD). The separation between AD and DLB clinically remains a challenge. We therefore need to establish in vivo biomarkers that can distinguish the differing pathologies and their contribution to the clinical features of the conditions. Diffusion tensor imaging (DTI) utilizes the anisotropic nature of diffusion in neuronal white matter tracts.1 With neuronal degeneration, the mean diffusivity (MD) increases with the loss of structural barriers that normally restrict diffusion, and diffusion becomes less directionally oriented, which is associated with a reduction in fractional anisotropy (FA). 2Previous studies investigating the DTI changes in DLB have used conventional region of interest (ROI) or voxel-based morphometry (VBM) methods.3-8 Some studies found widespread FA changes in comparison with healthy controls, 3,7 whereas others have found very little

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“…Most of these studies have involved clinical populations such as patients with schizophrenia (McGowan et al, 2004;Okubo et al, 1997; but see Abi-Dargham et al, 2002), Parkinson's disease (Bruck et al, 2005;Nagano-Saito et al, 2004), and Huntington's disease (Bä ckman et al, 1997;Lawrence et al, 1998). However, similarly strong DA-cognition associations are observed in normal samples of adults using striatal as well as extrastriatal DA markers (Landau et al, 2009;Mozley et al, 2001;Takahashi et al, 2007Takahashi et al, , 2008.…”

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confidence: 99%

Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues

Bäckman

Lindenberger

et al. 2010

Neuroscience & Biobehavioral Reviews

358

284

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Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies

Cited by 79 publications

References 85 publications

Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images

Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images

Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues

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