Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study

Basile, Gianpaolo Antonio; Iannuzzo, Fiammetta; Xerra, Francesco; Genovese, Giovanni; Pandolfo, Gianluca; Cedro, Clemente; Muscatello, Maria Rosaria Anna; Bruno, Antonio

doi:10.3390/ijerph20032358

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…Studies have shown that ALA may contribute to cognitive health [7]. A further study indicated that higher intake of ALA is associated with better cognitive function in older adults [38]. Fruits and vegetables rich in polyphenolic compounds are beneficial for improving cognitive function and preventing cognitive decline [39].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Lin,

Chiang

et al. 2023

Nutrients

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The brain is one of the most critical organs in the human body, regulating functions such as thinking, memory, learning, and perception. Studies have indicated that fish roe, snow fungus, and yeast may have the potential to modulate cognitive, memory, and emotional functions. However, more relevant clinical research in this area still needs to be conducted. This study explored the cognition-enhancing potential of a formula beverage including fish roe, snow fungus, and yeast. Sixty-four subjects were divided into a placebo group (n = 32) and a formula-drink group (n = 32), who consumed the product for 8 weeks. Cognitive tests were administered and analyzed at weeks 0, 4, and 8. After 4 and 8 weeks, there was a significant increase in the number of memory cards, and the response times among those who consumed the formula beverage were significantly faster than those in the placebo group. The subjects remembered the old items better and were more impressed with similar items based on the week effect. There was a significant increase in the cue effect of happy facial expressions after the subjects consumed the formula beverage for 8 weeks. In addition, there was a significant decrease in anxiety and fatigue, and improved quality of life. This formula beverage is a promising option that could be used to prevent further cognitive decline in adults with subjective cognitive complaints.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Lin,

Chiang

et al. 2023

Nutrients

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α-Lipoic acid as an ingredient of specialized food product and dietary supplement

Kodentsova,

Risnik

2023

Medicinskij alfavit

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A review of the literature in recent years was carried out using the RSCI, Google Scholar, Pubmed, and ResearchGate databases.The purpose of the review was to assess the content of α-lipoic acid (ALA) in foods and compare the doses allowed for use in dietary supplements and specialized food products with doses that provide a clinical effect. ALA or thioctic acid is synthesized in the organism and is also found in foods in free oxidized and reduced form, bound to proteins by hydrogen bonds, as well as covalently bound to lysine residues (lipoyl-lysine) in proteins, which complicates the analytical determination and reduces the bioavailability of this vitamin-like substances. Various methods for determining the natural content of individual forms (ALA and lipoyl-lysine) and their total content in food products have been described. The content of free ALA in 100 g of raw products of animal origin varies from 0.22 to 1.35 mg, of plant origin – from 0.22 to 2.04 mg. Losses during heat treatment reach 77–92%. Lipoyl–lysine content ranged from 2.11–3.99 µg/g heart, 0.56–1.17 µg/g liver, 0.71–1.40 µg/g kidney, while ALA amounts ranged from 0.22 up to 0.55 µg/g heart, from 0.38 to 0.51 µg/g liver. It is difficult to estimate the dietary intake of the total amount of all forms of ALA due to differences in extraction and detection methods. According to the domestic regulatory framework, the adequate level of ALA consumption for adults is 30 mg/day, the upper permissible level of daily consumption for adults as part of specialized food products (SFP), preventive and therapeutic nutrition and dietary supplements is 100 mg/day. ALA is often included in multicomponent dietary supplements and SPP in doses from 15 mg to 100 mg. A positive effect when taken for 10 or more weeks on lipid and carbohydrate metabolism, as well as other clinical effects in patients, is observed when taking ≥ 600 mg of ALA per day, which is significantly higher than the doses allowed for inclusion in the SFP.

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Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study

Cited by 2 publications

References 49 publications

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

α-Lipoic acid as an ingredient of specialized food product and dietary supplement

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