Cognitive and hippocampal effects of adult male mice exposure to environmentally relevant doses of phthalates

Ducroq, Suzanne; Duplus, Eric; Grange-Messent, Valérie; Trivelloni, Francesca; Penalva-Mousset, Lucille; Petropoulos, Isabelle; Mhaouty-Kodja, Sakina

doi:10.1016/j.envpol.2023.121341

Cited by 3 publications

(1 citation statement)

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“…Some studies have reported that DEHP disrupts the BBB integrity and surrounding parenchyma in the medial preoptic area and triggers an inflammatory profile in the HPC. 52,53 A recent finding suggested that DEHP-induced neurotoxicity is possibly associated with BBB dysfunction and neuroinflammation. 54 In the present study, DEHP induced TJ protein changes and disrupted the integrity of the BBB, resulting in an increase in permeability.…”

Section: Discussionmentioning

confidence: 99%

Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Zhao,

Chang,

Ren

et al. 2024

J. Agric. Food Chem.

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phthalate (DEHP), as the most common phthalate, has been extensively used as a plasticizer to improve the plasticity of agricultural products, which pose severe harm to human health. Mitochondrial dynamics and endoplasmic reticulum (ER) homeostasis are indispensable for maintaining mitochondria-associated ER membrane (MAM) integrity. In this study, we aimed to explore the effect of DEHP on the nervous system and its association with the ER−mitochondria interaction. Here, we showed that DEHP caused morphological changes, motor deficits, cognitive impairments, and blood−brain barrier disruption in the brain. DEHP triggered ER stress, which is mainly mediated by protein kinase R-like endoplasmic reticulum kinase (PERK) signaling. Moreover, DEHP-induced mitofusin-2 (Mfn2) downregulation results in imbalance of the mitochondrial dynamics. Interestingly, DEHP exposure impaired MAMs by inhibiting the Mfn2-PERK interaction. Above all, this study elucidates the disruption of the Mfn2-PERK axis-mediated ER−mitochondria interaction as a phthalate-induced neurotoxicity that could be potentially developed as a novel therapy for neurological diseases.

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Section: Discussionmentioning

confidence: 99%