Cognitive and clinical moderators of recognition memory in schizophrenia: a meta-analysis

Pelletier, Marc; Achim, Amélie M.; Montoya, Alonso; Lal, Samarthji; Lepage, Martín

doi:10.1016/j.schres.2004.08.017

Cited by 123 publications

(89 citation statements)

References 83 publications

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“…Moreover, the rather generalized impairment found in patients is in accordance with the results of the metaanalysis, which concluded that recollection and familiarity processes are impaired in SZ (Achim and Lepage, 2003;Pelletier et al, 2005). The absence of a deficit in the process of familiarity in unaffected parents can be taken as evidence for dual-process models, which posit that familiarity and recollection processes are distinct and dissociable (the inverse pattern, i.e.…”

Section: Discussionsupporting

confidence: 84%

“…Thus, a lower performance on both item and associative recognition tasks would suggest that recollection as well as familiarity processes are affected in SZ, while a deficit limited to the associative recognition task would indicate a selective impairment of the recollection process. Meta-analyses of studies of recognition memory (item and associative recognition tasks) revealed that people with SZ have impaired performance on both tasks (Achim and Lepage, 2003;Pelletier et al, 2005). The recollection deficit could be a potential endophenotype of SZ, as it has been found in adolescents with psychosis, in prepsychotic patients, in remitted and acutely ill patients (with and without auditory hallucinations) but also in unaffected first-degree relatives (Bartok et al, 2005;Waters et al, 2006;Brunelin et al, 2007;Doré et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Familiarity and recollection processes in patients with recent-onset schizophrenia and their unaffected parents

Lefèbvre

Cellard

Tremblay

et al. 2010

Psychiatry Research

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Episodic memory deficits are present in patients with schizophrenia (SZ) and their unaffected relatives and could be considered as a cognitive indicator of genetic vulnerability to SZ. The present study, involving patients with SZ as well as their parents, used experimental tasks specifically designed to disentangle the contribution of familiarity and recollection processes to episodic memory. The performance of patients with SZ (n=26) and their unaffected parents (n=35) was compared with that of healthy control groups matched on socio-demographic variables (controls of patients, n=26; controls of parents, n=35) on two memory tasks assessing recollection and familiarity. The first task was designed to investigate item recognition and memory for itemspatial context associations whereas the second targeted item-item associations. The results revealed an overall episodic memory deficit in patients with SZ, encompassing both familiarity and recollection, while unaffected parents showed a dysfunction restricted to the recollection process. Our study highlights differences and similarities in the source of the episodic memory deficit found in patients with SZ and their unaffected parents, and it suggests that recollection could act as a cognitive endophenotype of SZ. The results also suggest that use of experimental tasks represents a promising method in the search of cognitive endophenotypes in SZ.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Familiarity and recollection processes in patients with recent-onset schizophrenia and their unaffected parents

Lefèbvre

Cellard

Tremblay

et al. 2010

Psychiatry Research

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“…The level or type of impairments found in different studies were not always the same (Heinrichs and Zakzanis, 1998;Hoff and Kremen, 2003). Material or test specificity, etiologic subtypes, severity of symptoms, and duration of illness are examples of factors reported to contribute to between-subject or between-study heterogeneity in neurocognitive performance in schizophrenia (Heinrichs and Zakzanis, 1998;Kremen et al, 2004;Pelletier et al, 2005). Nonetheless, a meta-analysis found that the largest differences between cases and controls were in verbal memory, motor skills, attention, and executive functions, with effect sizes comparable to those seen in neuroimaging studies (Heinrichs and Zakzanis, 1998).…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive profile in 22q11 deletion syndrome and schizophrenia

Chow

Watson

Young

et al. 2006

Schizophrenia Research

169

192

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Objective-Schizophrenia is associated with neurocognitive deficits, but its etiologic heterogeneity may complicate the delineation of a neurocognitive profile. Schizophrenia associated with 22q11 Deletion Syndrome (22qDS) represents a more genetically homogeneous subtype for study. We hypothesized that in adults with 22qDS the neurocognitive profiles would differ between those with and without schizophrenia.Method-Using a comprehensive battery of tests, we compared the neurocognitive performance profiles in those with schizophrenia (n=27; 14 M, 13 F; mean age=30.6 years, SD=7.7 years) and those with no history of psychosis (n=29; 16 M, 13 F; mean age=25.0 years, SD=9.0 years).Results-The 22qDS groups with and without schizophrenia had similar mean estimated IQ (71.6, SD=8.2 and 74.8, SD=6.1, respectively) and academic achievement, however the neurocognitive profiles of the two groups differed significantly on multivariate analysis (F(24,31)=2.25, p=0.017). The group with schizophrenia performed significantly more poorly on tests of motor skills, verbal learning, and social cognition (effect sizes≥0.8) after correction for multiple comparisons. Other tests, but not the attentional measures used, showed nominally significant differences.Conclusions-In adults with 22qDS, the pattern of neurocognitive differences between those with and without schizophrenia appears similar to that between patients with schizophrenia and controls. Attentional dysfunction may be a more general feature of 22qDS. The findings support 22qDS-schizophrenia as a genetic model for neurodevelopmental investigations of schizophrenia.

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“…Patients with schizophrenia show robust deficits in declarative memory (Aleman et al 1999;Cirillo and Seidman 2003;Heinrichs and Zakzanis 1998;Kuperberg and Heckers 2000;Pelletier et al 2005), but the precise nature of these deficits and their neural underpinnings remain unresolved (Cirillo and Seidman 2003). A prominent model posits that the declarative memory deficits in schizophrenia are in part due to reduced conscious recollection and increased reliance on familiarity assessment as a basis for retrieval Danion et al 1999;Huron et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Remember and know judgments during recognition in chronic schizophrenia

Erp¹,

Lesh²,

Knowlton³

et al. 2008

Schizophrenia Research

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Deficits in learning and memory are among the most robust correlates of schizophrenia. It has been hypothesized that these deficits are in part due to reduced conscious recollection and increased reliance on familiarity assessment as a basis for retrieval. The Remember-Know (R-K) paradigm was administered to 35 patients with chronic schizophrenia and 35 healthy controls. In addition to making "remember" and "know" judgments, the participants were asked to make forced choice recognition judgments with regard to details about the learning episode. Analyses comparing response types showed a significant reduction in "remember" responses and a significant increase in "know" responses in schizophrenia patients relative to controls. Both patients and controls recalled more details of the learning episode for "remember" compared to "know" responses, although, in particular for "remember" responses, patients recalled fewer details compared with controls. Notably, patients recognized fewer inter-item but not intra-item stimulus features compared with controls. These findings suggest deficits in organizing and integrating relational information during the learning episode and/or using relational information for retrieval. A Dual-Process Signal Detection interpretation of these findings suggests that recollection in chronic schizophrenia is significantly reduced, while familiarity is not. Additionally, a unidimensional Signal Detection Theory interpretation suggests that chronic schizophrenia patients show a reduction in memory strength, and an altered criterion on the memory strength distribution for detecting new compared with old stimuli but not for detecting stimuli that are remembered versus familiar. Taken together, these findings are consistent with a deficit in recollection and increased reliance on familiarity in making recognition memory judgments in chronic schizophrenia.

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Cognitive and clinical moderators of recognition memory in schizophrenia: a meta-analysis

Cited by 123 publications

References 83 publications

Familiarity and recollection processes in patients with recent-onset schizophrenia and their unaffected parents

Familiarity and recollection processes in patients with recent-onset schizophrenia and their unaffected parents

Neurocognitive profile in 22q11 deletion syndrome and schizophrenia

Remember and know judgments during recognition in chronic schizophrenia

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