Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers

Meador, Kimford J.; Loring, David W.; Vahle, Victoria; Ray, Paul H.; Werz, Mary Ann; Fessler, A. James; Ogrocki, Paula; Schoenberg, Mike R.; Miller, James M.; Kustra, Robert P.

doi:10.1212/01.wnl.0000165994.46777.be

Cited by 135 publications

(111 citation statements)

References 38 publications

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“…Antiepileptics drugs (AEDs) have both negative and positive effects on cognition and behavior [37]. AEDs are able to improve cognition and behavior, which has been attributed to reduction of seizure activity, and modulating effect on neurotransmitters and their psychotrophic effect.…”

Section: Effect Of Antiepileptic Drugsmentioning

confidence: 99%

A Review of Epilepsy Stigma in Egypt

Shehata¹

2016

Acta Psychopathologica

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Section: Effect Of Antiepileptic Drugsmentioning

confidence: 99%

A Review of Epilepsy Stigma in Egypt

Shehata¹

2016

Acta Psychopathologica

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“…Moreover, no patients were using topiramate for seizure control, a compound that has been shown to affect neuropsychological function. 38 There has been a longstanding debate in epileptology regarding the concept of "idiopathic generalized" epilepsies and seizures. Studies in animal models strongly suggest focal cortical onset of classic "primary generalized" absence seizures, 39 and such findings are beginning to receive support from human investigations.…”

Section: Neuropsychological and Brain Region Relationshipsmentioning

confidence: 99%

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

O’Muircheartaigh¹,

Vollmar²,

Barker³

et al. 2011

Neurology

152

148

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Objective: The aim of this study was to determine if there were focal cortical abnormalities in juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI. Methods:Twenty-eight patients with JME and a large sample of healthy controls were assessed using a series of neuropsychological tests as well as structural and diffusion tensor MRI (DTI). DTI measures assessed fractional anisotropy (FA) within a white matter skeleton.Results: Neuropsychological testing indicated subtle dysfunctions in verbal fluency, comprehension, and expression, as well as nonverbal memory and mental flexibility. Utilizing whole-brain voxel-based morphometry for gray matter MRI data and tract-based spatial statistics for white matter diffusion MRI data, we found reductions in gray matter volume (GMV) in the supplementary motor area and posterior cingulate cortex and reductions in FA in underlying white matter of the corpus callosum. Supplementary motor area FA predicted scores in word naming tasks and expression scores. Posterior cingulate cortex GMV and FA predicted cognitive inhibition scores on the mental flexibility task. Conclusions:The neuropsychological, structural, and tractography results implicate mesial frontal cortex, especially the supplementary motor area, and posterior cingulate cortex in JME. Juvenile myoclonic epilepsy (JME) is a common type of idiopathic generalized epilepsy (IGE), accounting for approximately 4%-11% of all epilepsies. It is characterized by an age-specific onset of epilepsy with myoclonic jerks, generalized tonic-clonic seizures, and, less frequently, absences. 1A typical abnormality detected by EEG is bilateral spike or polyspike and wave complexes, often strongest in frontocentral areas.2 Further focal or asymmetric abnormalities on EEG occur in approximately 30% of patients. 3,4 Fifty years ago patients with JME were noted to have personality traits previously considered to characterize frontal lobe pathology.5 Studies examining neuropsychological aspects have identified a range of deficits, for example impaired performance on tasks of mental flexibility and cognitive speed. 6 More recently, further impairments in executive functions have been highlighted. 7-10

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“…Estudos realizados por e Meador et al (2005) indicam que as drogas antiepiléticas além de reduzir e/ou extinguir a frequência das crises, possuem como efeitos secundários lentidão psicomotora, redução da atenção e concentração, assim como problemas de memória, que poderiam levar a problemas de aprendizagem e outros comprometimentos acadêmicos.…”

Section: Discussionunclassified

Educação especial e inclusão educacional: discussões, práticas e depoimentos dentro das redes de ensino

Ferreira¹,

Dechichi²,

Silva³

2015

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Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers

Cited by 135 publications

References 38 publications

A Review of Epilepsy Stigma in Egypt

A Review of Epilepsy Stigma in Egypt

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

Educação especial e inclusão educacional: discussões, práticas e depoimentos dentro das redes de ensino

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