Cognitive and affective disturbances following focal cerebellar damage in adults: A neuropsychological and SPECT study

Baillieux, Hanne; Smet, Hyo Jung De; Dobbeleir, André; Paquier, Philippe; Deyn, Peter Paul De; Mariën, Peter

doi:10.1016/j.cortex.2009.09.002

Cited by 149 publications

(99 citation statements)

References 51 publications

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“…An Italian group reported similar observations later the same year (Riva and Giorgi 2000). There are now numerous reports of this constellation of deficits in patients with cerebellar lesions of different etiologies, in patients of different ages, and from research groups in different continents (e.g., Molinari et al 1997Molinari et al , 2004Neau et al 2000;Rapoport et al 2000;Sadeh and Cohen 2001;Steinlin et al 2003;Exner et al 2004;Baillieux et al 2010;Timmann et al 2010). Some studies fail to document these findings (Gomez Beldarrain et al 1997;Richter et al 2007), a result that may be related to lesion location, as outlined later.…”

Section: The Cerebellar Cognitive Affective Syndromementioning

confidence: 85%

The Role of the Cerebellum in Cognition and Emotion: Personal Reflections Since 1982 on the Dysmetria of Thought Hypothesis, and Its Historical Evolution from Theory to Therapy

2010

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The cognitive neuroscience of the cerebellum is now an established multidisciplinary field of investigation. This essay traces the historical evolution of this line of inquiry from an emerging field to its current status, with personal reflections over almost three decades on this journey of discovery. It pays tribute to early investigators who recognized the wider role of the cerebellum beyond motor control, traces the origins of new terms and concepts including the dysmetria of thought theory, the universal cerebellar transform, and the cerebellar cognitive affective syndrome, and places these developments within the broader context of the scientific efforts of a growing community of cerebellar cognitive neuroscientists. This account considers the converging evidence from theoretical, anatomical, physiological, clinical, and functional neuroimaging approaches that have resulted in the transition from recognizing the cerebellar incorporation into the distributed neural circuits subserving cognition and emotion, to a hopeful new era of treatment of neurocognitive and neuropsychiatric manifestations of cerebellar diseases, and to cerebellar-based interventions for psychiatric disorders.

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Section: The Cerebellar Cognitive Affective Syndromementioning

confidence: 85%

The Role of the Cerebellum in Cognition and Emotion: Personal Reflections Since 1982 on the Dysmetria of Thought Hypothesis, and Its Historical Evolution from Theory to Therapy

2010

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“…This is supported by the fact that global white matter changes reflecting demyelination and thus disrupting trans-synaptic communications have been implicated as a possible mechanism underlying post-irradiation brain injury causing cognitive deficits [39;40]. Similarly, a diffusion tensor imaging based study in children with posterior fossa tumors revealed that disruption of cerebello-thalamocerebral pathways following irradiation were associated with poorer working memory, a core cognitive skill involved in complex cognitive functions including IQ and academics [41]. The same authors stated that diffuse white matter changes in the posterior fossa following irradiation and disruption of multiple other pathways connecting cerebellum to supratentorial structures may have been responsible for deficits.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cerebellum Radiation Dosimetry on Cognitive Outcomes in Children with Infratentorial Ependymoma

Sharma

Conklin

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…These tend to involve neglect of features in detection tasks with multiple objects and in particular the failure or marked slowing of covert attentional shifts as measured by reaction times (E. Courchesne et al 1994). Changes in a number of executive functions including working memory, set shifting and even emotional dysregulation have been attributed to cerebellar damage in lesion studies (Baillieux et al 2010;Jeremy D. Schmahmann 2004). A group of cerebellar patients with a variety of underlying causes showed modest to moderate impairments in a range of cognitive tasks including visuospatial, sequencing, attention and executive (Tedesco et al 2011).…”

Section: Cerebellum and Spatial Cognitionmentioning

confidence: 99%

“…Subjects with cerebellar lesions have deficits more commonly associated with parietal function, including disturbances of attention (Baillieux et al 2010), ideomotor apraxia and right unilateral neglect (Silveri, Misciagna, and Terrezza 2001).…”

Section: Cerebellum and Spatial Cognitionmentioning

confidence: 99%

A theory inspired proposal for a novel medical treatment in autism. The cerebellar model of autism and the hypothesis of dorsal stream dysfunction: evidence from idiopathic and syndromic cases.

Vakalopoulos¹

2017

Preprint

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The cerebellum figures prominently in the pathophysiology of idiopathic autism. Many syndromic comorbid cases and animal studies also highlight cerebellar involvement. The role of the cerebellum is implicated in cognitive and affective disorders. However, there remains a profound gap in understanding the route from genes, the effect of mutations on Purkinje cells and ultimately the behavioural phenotype. Given that conditions like autism are disorders of consciousness it is likely that progress will be made beyond the data generating enterprise, by improved theoretical models of the mind-body gap. A way forward is the proposal of consciousness as embodiment of a process of world discovery through motor efference copy. The cerebellum and basal ganglia are essential to a component theory of motor efference copy, providing a heuristic for understanding the structure of cortical dorsal and ventral stream pathways of a sensory modality. This then, further suggests that autism results from a selective dorsal stream dysfunction with all the attendant and hierarchical features that follow such a model and lead to both high level social and attentional deficits as well as lower level motor and restrictive interests. The paper aims to present evidence for dorsal stream dysfunction and how it may relate to a primary cerebellar pathology. The involvement of the cerebellum in most if not all syndromic cases of comorbid ASD is then presented. Finally, it is shown how such insights can be used to propose a general medical intervention based on the use of cerebellar rTMS across the disorder spectrum.

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Cognitive and affective disturbances following focal cerebellar damage in adults: A neuropsychological and SPECT study

Cited by 149 publications

References 51 publications

The Role of the Cerebellum in Cognition and Emotion: Personal Reflections Since 1982 on the Dysmetria of Thought Hypothesis, and Its Historical Evolution from Theory to Therapy

The Role of the Cerebellum in Cognition and Emotion: Personal Reflections Since 1982 on the Dysmetria of Thought Hypothesis, and Its Historical Evolution from Theory to Therapy

The Effect of Cerebellum Radiation Dosimetry on Cognitive Outcomes in Children with Infratentorial Ependymoma

A theory inspired proposal for a novel medical treatment in autism. The cerebellar model of autism and the hypothesis of dorsal stream dysfunction: evidence from idiopathic and syndromic cases.

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