2022
DOI: 10.1146/annurev-clinpsy-072720-014213
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Cognitive Aging and the Promise of Physical Activity

Abstract: Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting to emphasize the hope of preservation and enhancement of cognitive function in late life? A fragment of an answer comes from research attempting to understand the reasons for individual variability in the extent and rate of cognitive decline. This body of work has created a sense of optimism based on evidence that there are some health behaviors that amplify cognitive performance or mitigate the rate of age-rel… Show more

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Cited by 66 publications
(54 citation statements)
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“…However, in men, LT was not related to the type of exercise. Several studies are currently looking at associations between PA and cognitive functions [ 4 , 5 , 8 , 12 , 16 , 36 , 37 , 38 ] or learning achievements [ 39 , 40 , 41 , 42 ]. To determine the effectiveness of intuitive thinking and LT, we selected the CRT [ 26 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, in men, LT was not related to the type of exercise. Several studies are currently looking at associations between PA and cognitive functions [ 4 , 5 , 8 , 12 , 16 , 36 , 37 , 38 ] or learning achievements [ 39 , 40 , 41 , 42 ]. To determine the effectiveness of intuitive thinking and LT, we selected the CRT [ 26 ].…”
Section: Discussionmentioning
confidence: 99%
“…There is an increasing amount of evidence-based research showing that various forms and doses of physical activity (PA) or exercise are effective in combating many chronic diseases [ 1 , 2 ] and improving well-being and mental health [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. The health benefits of PA are influenced by age, sex, health, and body mass index (BMI) [ 10 , 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Given that higher levels of physical inactivity and sedentary behavior are associated with detrimental health consequences [ 23 , 39 43 ], the above-presented evidence suggests that, especially in the aging population, appropriate countermeasures such as interventions to promote regular and structured forms of physical activity - defined as physical exercise and/or physical training (see Table 1 ) - should be initiated. The latter idea is strongly reinforced by mounting evidence showing that regular and structured forms of physical activity are a crucial element of healthy aging [ 44 51 ].…”
Section: Introductionmentioning
confidence: 99%
“…There might be a variety of processes behind the benefits of PE, including cellular and molecular, brain structure and function, and psychosocial mechanisms ( Stillman et al, 2020 ). Biological mechanisms underlying cognitive and emotional benefits of PE include increased production of growth factors (e.g., BDNF, IGF-1), and decreased synthesis of pro-inflammatory molecules (e.g., CRP, IL-6), and accumulation of markers of neurodegeneration ( Kandola et al, 2019 ; Stillman et al, 2020 ; Erickson et al, 2022 ). At a brain level, the positive influence of PE on the hippocampus and prefrontal gray matter volume ( Erickson et al, 2014 ), global white matter volume ( Sexton et al, 2016 ), and increased cross-network specificity across various functional networks ( Stillman et al, 2019 ) have been described.…”
Section: Introductionmentioning
confidence: 99%