Cognitive/affective and somatic/affective symptom dimensions of depression are associated with current and future inflammation in heart failure patients

Abstract

Baseline cognitive/affective depressive symptoms were prospectively associated with sTNFR1 and sTNFR2 in HF patients, while change in somatic/affective depressive symptoms was associated with sTNFR2, independent from clinical and demographic covariates. Further studies are warranted to replicate these findings and to examine the association between depression dimensions, inflammation and prognosis in HF.

The role of neutrophil gelatinase associated lipocalin (NGAL) as biological constituent linking depression and cardiovascular disease

“…It is worth mentioning that compared to depressed patients without heart disease, depressed patients with heart disease suffer from somatic/affective-rather than from cognitive/affective symptoms of depression (Holzapfel et al, 2008). Moreover, in heart failure patients, inflammation is associated with somatic symptoms of depression, but not with cognitive/affective symptoms (Kupper et al, 2012).…”

Depressive symptoms and white blood cell count in coronary heart disease patients: Prospective findings from the Heart and Soul Study

“…Depression has been found to have a negative influence on cardiac prognosis (van Melle et al, 2004), but the mechanisms of this association remain unclear (de Jonge et al, 2010). Several studies have evaluated the association between depression and inflammatory markers, including interleukin (IL)6, high sensitive C-reactive protein (hsCRP), tumor necrosis factor (TNF)-a and its soluble receptors (Penninx et al, 2003;Whooley et al, 2007;Kupper et al, 2012;Vogelzangs et al, 2012). A meta-analysis reported small to moderate cross-sectional associations between depression and these cytokines, both in healthy subjects and in cardiac patients (Howren et al, 2009).…”

“…A meta-analysis reported small to moderate cross-sectional associations between depression and these cytokines, both in healthy subjects and in cardiac patients (Howren et al, 2009). Currently, several prospective studies have been performed (Gimeno et al, 2009;Stewart et al, 2009;Duivis et al, 2011;Shaffer et al, 2011;Kupper et al, 2012). In a recent study in heart failure patients, depressive symptoms at baseline were associated with current and future inflammation after 1 year follow-up, independent of classic cardiovascular risk factors, disease severity and adverse health behaviors (Kupper et al, 2012).…”

“…Currently, several prospective studies have been performed (Gimeno et al, 2009;Stewart et al, 2009;Duivis et al, 2011;Shaffer et al, 2011;Kupper et al, 2012). In a recent study in heart failure patients, depressive symptoms at baseline were associated with current and future inflammation after 1 year follow-up, independent of classic cardiovascular risk factors, disease severity and adverse health behaviors (Kupper et al, 2012). In line with this, we found in a previous study that depressive symptoms predicted subsequent levels of hsCRP and IL-6 over a period of 5 years in patients with coronary heart disease (CHD), but not vice versa (Duivis et al, 2011).…”

sTNFr1 and it's contributory role in the evolution and progression of different psychiatric disorders

“…A significant association has been seen between sTNFr1 levels and the cognitive/ affective aspect of depression (2). This is especially more pronounced in patients with coexisting comorbidities such as congestive heart failure.…”