Cognitive adverse events in patients with lung cancer treated with checkpoint inhibitor monotherapy: a propensity score-matched analysis

Ma, Yifei; Liu, Nianqi; Wang, Yanqi; Zhang, Ao; Zhu, Zi‐Zhong; Zhang, Zhiying; Li, Yiming; Jian, Guangmin; Fu, Guangzhen; Dong, Ming; Zheng, Guangmei; Zhu, Pengfei; Zhong, Guanqing; Bai, Shenrui; Chen, Shuqin; Wei, Xiao-Long; Tan, Jia-Yi; Wang, Xinjia

doi:10.1016/j.eclinm.2023.101987

Cited by 3 publications

(5 citation statements)

References 33 publications

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“…Most studies ( n = 5; 41.6%) adopted a prospective study design [ 27 – 31 ]. In terms of the location and region where the studies were conducted, six studies were carried out in Asia [ 28 , 29 , 32 – 35 ], two studies in North America [ 27 , 36 ], and four in Europe [ 30 , 31 , 37 , 38 ]. The sample size of included studies ranged from 8 to 480; the ratio of male cancer survivors in the studies ranged from 46 to 100%.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies (33.3%) reported that CRCI was assessed by neuropsychological tests using the International Cognition and Cancer Task Force (ICCTF) criteria [ 27 , 29 , 36 , 37 ], three studies (25%) applied the Mini-Mental State Examination (MMSE) [ 28 , 30 , 34 ], and one study (8.3%) reported the application of the Short Portable Mental State Questionnaire (SPMSQ) [ 38 ]. Subjective assessments measuring perceived cognitive impairment for CRCI are frequently used as well.…”

Section: Resultsmentioning

confidence: 99%

“…(Memory) 10, 11 Abbreviations. COWA Controlled Oral Word Association, HVLT-R Hopkins Verbal Learning Test-Revised, CANTAB Cambridge Neuropsychological Test Automated Battery, WAIS-R Wechsler Adult Intelligence Scale-Revised, TMT Trail Making Test, MMSE Mini-Mental State Examination, CogPCI Perceived Cognitive Impairments subscale, SPMSQ Short Portable Mental State Questionnaire, FACT-Cog Functional Assessment of Cancer Therapy, EORTC QLQ-C30 European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire References in this table: 1[ 37 ]; 2[ 36 ]; 3[ 27 ]; 4[ 28 ]; 5[ 33 ]; 6[ 29 ]; 7[ 30 ]; 8[ 34 ]; 9[ 38 ]; 10[ 35 ]; 11[ 31 ] …”

Section: Resultsmentioning

confidence: 99%

“…References in this table: 1[ 37 ]; 2[ 36 ]; 3[ 27 ]; 4[ 28 ]; 5[ 33 ]; 6[ 29 ]; 7[ 30 ]; 8[ 34 ]; 9[ 38 ]; 10[ 35 ]; 11[ 31 ]…”

Section: Resultsunclassified

“…In line with the six key domains of cognitive function defined by the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) [ 39 ], most major domains were covered; however, the social cognition and emotions domain was not reported in the included studies. It is noted that the Cambridge Neuropsychological Test Automated Battery (CANTAB) was used in an included study partially (for measuring visuospatial memory only) [ 29 ]. In fact, the CANTAB test batteries include emotion and social cognition domain such as Emotion Bias Task (EBT) and Emotion Recognition Task (ERT) to measure distinct aspects of social cognition [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and assessment tools of cancer-related cognitive impairment in lung cancer survivors: a systematic review and proportional meta-analysis

Ho,

So,

Fan

et al. 2024

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Purpose Cancer-related cognitive impairment (CRCI) is a significant risk factor influencing the quality of life in lung cancer survivors. No absolute assessment tool has been confirmed to assess CRCI in lung cancer survivors. This review was undertaken to pool the overall prevalence of CRCI and to summarize the assessment tools in assessing CRCI among lung cancer survivors. Methods PubMed, Cochrane Library, Embase, CINAHL, and CNKI were searched to retrieve articles reported CRCI prevalence. Summary prevalence estimates were pooled using a random effects model, along with corresponding 95% prediction intervals (PIs). The Freeman-Tukey double arcsine transformation of proportions was incorporated in the analysis. Additionally, subgroup analysis, meta-regression, and leave-one-out analysis were performed. Results A total of 12 studies, involving 1934 survivors, were included in the review. All of these studies were found to have a low risk of bias in terms of their methodological quality. Four studies (33.3%) utilized the International Cognition and Cancer Task Force (ICCTF) criteria to identify CRCI through neuropsychological tests. The pooled prevalence rate of CRCI was found to be 26% (95% PI, 16–37%), I2 = 95.97%. The region in which the studies were conducted was identified as a significant factor contributing to this heterogeneity (p = 0.013). No indication of small-study effects was found (Egger’s test: p = 0.9191). Conclusion This review provides an overview of CRCI prevalence and assessment tools in lung cancer survivors. The findings can serve as epidemiological evidence to enhance clinicians’ and researchers’ understanding of early detection and assessment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…References in this table: 1[ 37 ]; 2[ 36 ]; 3[ 27 ]; 4[ 28 ]; 5[ 33 ]; 6[ 29 ]; 7[ 30 ]; 8[ 34 ]; 9[ 38 ]; 10[ 35 ]; 11[ 31 ]…”

Section: Resultsunclassified

Section: Discussionmentioning

confidence: 99%

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Prevalence and assessment tools of cancer-related cognitive impairment in lung cancer survivors: a systematic review and proportional meta-analysis

Ho,

So,

Fan

et al. 2024

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Immune Checkpoint Inhibitors and Their Impact on Thoughts, Feelings, and Behavior: Cognitive and Psychiatric Manifestations of Immune Checkpoint Therapy

Ahuja,

Varma

2024

Indian Journal of Psychological Medicine

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Expression profile and prognostic value of the circadian clock in clear cell renal cell carcinoma

Kong

Zhao

Wang

et al. 2023

Preprint

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Background A growing number of studies indicate that the circadian clock is a crucial regulator of tumorigenesis and the progression of diverse cancers. Clear cell renal cell carcinoma (ccRCC) is an extremely malignant tumor with a poor prognosis. However, the implications of circadian clock genes in ccRCC remain poorly understood.Methods We evaluated the expression pattern of circadian clock genes and their prognostic significance in ccRCC. Cluster analysis and Gene set enrichment analysis (GSEA) were used to assess the biological mechanisms of subgroups. Cox regression, GO and KEGG enrichment analysis, ESTIMATE, CIBERSORTx, and ceRNA networks were utilized to investigate the prognostic significance and underlying mechanisms of the circadian clock in ccRCC.Results We found a strong correlation between 17 circadian clock genes and ccRCC prognosis. Eight circadian clock genes were chosen to construct a new risk signature that categorized all ccRCC patients as low- or high-risk. The low-risk group had significantly greater chances of survival than the high-risk group (P < 0.001). In conjunction with clinical characteristics, the risk score was identified as an independent prognostic factor for patients with ccRCC. Immune infiltration analysis revealed that T cells CD4 memory resting, Macrophages M1, Mast cells resting, Dendritic cells resting, and Monocytes were significantly higher in the low-risk subgroup, whereas the high-risk subgroup had a greater proportion of T cells regulatory (Tregs), which was consistent with the pathways identified by ssGSEA. Finally, the ceRNA network was constructed successfully, and the significantly low expression levels of FBXL3 and HLF were verified in human RCC tissues.Conclusion Our research uncovered the crucial role of circadian clock genes in tumor immunity and identified a risk signature as a promising biomarker for predicting the prognosis of patients with ccRCC. Our findings lay the groundwork for future research focusing on the circadian clock and immune microenvironment to improve the prognosis and immunotherapy responses in ccRCC.

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Cognitive adverse events in patients with lung cancer treated with checkpoint inhibitor monotherapy: a propensity score-matched analysis

Cited by 3 publications

References 33 publications

Prevalence and assessment tools of cancer-related cognitive impairment in lung cancer survivors: a systematic review and proportional meta-analysis

Prevalence and assessment tools of cancer-related cognitive impairment in lung cancer survivors: a systematic review and proportional meta-analysis

Immune Checkpoint Inhibitors and Their Impact on Thoughts, Feelings, and Behavior: Cognitive and Psychiatric Manifestations of Immune Checkpoint Therapy

Expression profile and prognostic value of the circadian clock in clear cell renal cell carcinoma

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