Cognition in pediatric SDB—Yes, no, maybe?

Garagozzo, Ariana

doi:10.1002/ppul.25420

Cited by 2 publications

(4 citation statements)

References 56 publications

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“…Further research on the impact of snoring on cognition is needed with children born preterm who have lower global and specific cognitive impairments relative to children born at term [70]. This rationale is evidenced from research in the general population, in which school-aged children with SDB have poorer scores on global cognitive assessments, such as IQ [85] not on standardised assessments of working memory, inhibition, shifting, or vigilance [86] compared with children without SDB. However, these scores tend to remain within the average range [85].…”

Section: Sleep-disordered Breathing In Childhood Following Preterm Birthmentioning

confidence: 99%

“…This rationale is evidenced from research in the general population, in which school-aged children with SDB have poorer scores on global cognitive assessments, such as IQ [85] not on standardised assessments of working memory, inhibition, shifting, or vigilance [86] compared with children without SDB. However, these scores tend to remain within the average range [85].…”

Section: Sleep-disordered Breathing In Childhood Following Preterm Birthmentioning

confidence: 99%

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The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications

et al. 2022

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There is emergent literature on the relationship between the development of sleep-wake cycles, sleep architecture, and sleep duration during the neonatal period on neurodevelopmental outcomes among children born preterm. There is also a growing literature on techniques to assess sleep staging in preterm neonates using either EEG methods or heart and respiration rate. Upon discharge from hospital, sleep in children born preterm has been assessed using parent report, actigraphy, and polysomnography. This review describes the ontogeny and measurement of sleep in the neonatal period, the current evidence on the impact of preterm birth on sleep both in the NICU and in childhood and adolescence, and the interaction between sleep, cognition, and social-emotional outcomes in this population.

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Section: Sleep-disordered Breathing In Childhood Following Preterm Birthmentioning

confidence: 99%

Section: Sleep-disordered Breathing In Childhood Following Preterm Birthmentioning

confidence: 99%

The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications

et al. 2022

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Section: Observations and Discussionmentioning

confidence: 99%

“…Previous observational studies appeared to suggest that children with OSA have lower general intelligence, language, visuospatial, and memory skills compared with non-OSA controls. 5,23,24 Therefore, the primary outcome of the CHAT study was the postrandomization change in the attention and executive function score on the Developmental Neuropsychological Assessment (NEPSY A/E). 25 The NEPSY is a cognitive test with well-established psychometric properties and comprises 3 tasks (tower building, visual attention, and auditory attention) performed with the supervision of a psychometrist.…”

Section: Cognitionmentioning

confidence: 99%

Secondary Analyses of the Childhood Adenotonsillectomy Trial

Decuzzi

Redline

Isaiah

2022

JAMA Otolaryngol Head Neck Surg

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ImportanceAdenotonsillectomy, performed for approximately 500 000 children annually in the US alone, is the first line of treatment of pediatric obstructive sleep apnea (OSA). The Childhood Adenotonsillectomy Trial (CHAT), the first randomized clinical trial to test the efficacy of adenotonsillectomy, compared the management of pediatric nonsevere OSA by early adenotonsillectomy (eAT) vs watchful waiting with supportive care. Since the publication of the primary article in 2013, the CHAT study data set were made available via the National Sleep Research Resource, which allowed researchers to address a range of additional clinical questions relevant to the care of children with OSA. This review focuses on secondary analyses associated with the CHAT data set as grouped by the outcome of interest.ObservationsThe results of most secondary analyses suggest that children who underwent eAT experienced the greatest improvements in symptom burden, sleepiness, parent-reported behavior, and quality of life. Changes in other domains, such as cognition, cardiovascular physiology, and metabolic indicators, were modest and selective. The associations between most treatment outcomes and polysomnographic parameters were weak. Symptoms were poor predictors of OSA severity. The results from these secondary analyses benefitted from the rigor of multicenter design and centralized polysomnography interpretation in CHAT. However, the exclusion of younger preschool-aged children and children with primary snoring limited the generalizability of findings. In addition, because caregivers were not masked, some of the parent-reported outcomes may have been inflated.Conclusions and RelevanceThe results of this narrative review suggest that CHAT provides a model for future OSA-related studies in children for design, conduct, and subsequent reuse of the study data set, and its findings have advanced our understanding of the pathophysiology and management of pediatric nonsevere OSA. Directions for future research include whether the findings from this landmark study are generalizable to younger children and children with primary snoring and severe OSA. Similar studies may help address practice variability associated with pediatric OSA and help identify children who are most likely to benefit from undergoing eAT.

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Cognition in pediatric SDB—Yes, no, maybe?

Cited by 2 publications

References 56 publications

The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications

The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications

Secondary Analyses of the Childhood Adenotonsillectomy Trial

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