Cognition in patients with benign epilepsy with centrotemporal spikes: A study with long-term VEEG and RS-fMRI

Yan, X X; Yu, Qing; Gao, Y T; Li, Liting; Yu, D H; Chen, Ying; Yao, Xiaojuan; Yang, Weidong; Chen, Zhijuan; Yin, Jianzhong; An, Yang; Tan, K

doi:10.1016/j.yebeh.2017.06.033

Cited by 17 publications

(29 citation statements)

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“…Although their FSIQ scores fell within the normal range, they were at the lower limit of the normal value, with some patients scoring lower than normal. This is consistent with previous studies [6,9,18]. However, we found that around half of the children with BECTS had poor cognitive function with an FSIQ score of less than 80, suggesting that cognitive function is affected early in a significant proportion of children with BECTS.…”

Section: The Wisc-iv Scoresupporting

confidence: 93%

“…In children with BECTS, these cognitive impairments may be mainly related to frequent discharge during sleep [5]. Some studies have shown that children with early BECTS have significant cognitive impairment [6,7]. However, numerous studies continue to report that cognitive impairment in BECTS is not obvious and that cognitive decline only exists in specific cognitive fields [3,4].…”

Section: Introductionmentioning

confidence: 99%

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The relationship between neuromagnetic activity and cognitive function in benign childhood epilepsy with centrotemporal spikes

Sun

Niu

et al. 2020

Epilepsy & Behavior

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Our aim was to explore the pathophysiological mechanism of cognitive function changes in early untreated children with benign childhood epilepsy with centrotemporal spikes (BECTS). Methods: Magnetoencephalography (MEG) was performed in 33 children with BECTS and 18 healthy children. Wechsler Intelligence Scale for Children, fourth edition (WISC-IV) was used to divide children with BECTS into two groups. Normal cognitive function was defined as a full-scale intelligence quotient (FSIQ) of N 80, while decreased cognitive function was defined as a FSIQ of b 80. Accumulated source imaging was used to evaluate the neuromagnetic source activity in multifrequency bands. Results: Of the 33 patients with early untreated BECTS, a total of 17 had a FSIQ of b 80 and 16 had FSIQ of N 80. The course of epilepsy and number of seizures in the FSIQ b80 group were higher than that in the FSIQ N 80 group. Our MEG results showed that in the 4-8 Hz frequency band, both patient groups had inactivation of the posterior cingulate cortex (PCC) region compared with the healthy control group. In the 30-80 Hz frequency band, the FSIQ b 80 group showed inactivation of the PCC region compared with both the healthy control group and the FSIQ N 80 group. In the 80-250 Hz frequency band, the FSIQ b80 group had inactivated of the medial frontal cortex (MFC) region compared with the healthy control group. In the 30-80 Hz frequency band, the strength of neuromagnetic source in patients with BECTS with FSIQ b80 was higher than that in the FSIQ N 80 group and the healthy control group. Conclusions: The magnetic source inactivation of the MFC and PCC regions during the interictal time may be the reason for cognitive decline in early untreated children with BECTS. Children with BECTS with cognitive decline had a longer course of epilepsy and more seizures. The magnetic source localization in the 4-8 Hz frequency band may be a new imaging marker for the diagnosis of new BECTS.

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Section: The Wisc-iv Scoresupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The relationship between neuromagnetic activity and cognitive function in benign childhood epilepsy with centrotemporal spikes

Sun

Niu

et al. 2020

Epilepsy & Behavior

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“…However, recent studies have shown that BECTS children have some degree of cognitive impairment, behavioral and social impairment, and psychotic comorbidities (Eom et al, 2014;Neri et al, 2012;Völkl-Kernstock et al, 2009;Yan et al, 2017), with speech impairment and executive dysfunction being the most prominent (Neri et al, 2012;Parisi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes

Sun

Zhang

et al. 2020

Brain and Behavior

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“…More than the single ED event, abundance (or frequency) of ED in CECTS is considered a risk factor for epileptogenesis (16) and deficits in cognition processing (17), especially during sleep. Recently, altered widespread functional connectivity patterns were observed in CECTS with spike-wave index during non-rapid eye movement sleep ≥50% compared with the spike-wave index ≤50% group, and these alterations were associated with a worse cognitive profile, while no relationship was detected with age of epilepsy onset, disease course, years of education, and total number of seizures (18). For epileptiform activity in wakefulness, it is shown that reading cognitive performances in children with CECTS were higher disrupted when the awake EEG showed high density of spikes than when the EEG was spike free (19).…”

Section: Introductionmentioning

confidence: 99%

Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes

et al. 2019

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Childhood epilepsy with centrotemporal spikes (CECTS) is the most common type of "self-limited focal epilepsies." In its typical presentation, CECTS is a condition reflecting non-lesional cortical hyperexcitability of rolandic regions. The benign evolution of this disorder is challenged by the frequent observation of associated neuropsychological deficits and behavioral impairment. The abundance (or frequency) of interictal centrotemporal spikes (CTS) in CECTS is considered a risk factor for deficits in cognition. Herein, we captured the hemodynamic changes triggered by the CTS density measure (i.e., the number of CTS for time bin) obtained in a cohort of CECTS, studied by means of video electroencephalophy/functional MRI during quite wakefulness. We aim to demonstrate a direct influence of the diurnal CTS frequency on epileptogenic and cognitive networks of children with CECTS. A total number of 8,950 CTS (range between 27 and 801) were recorded in 23 CECTS (21 male), with a mean number of 255 CTS/patient and a mean density of CTS/30 s equal to 10,866 ± 11.46. Two independent general linear model models were created for each patient based on the effect of interest: "individual CTS" in model 1 and "CTS density" in model 2. Hemodynamic correlates of CTS density revealed the involvement of a widespread cortical-subcortical network encompassing the sensory-motor cortex, the Broca's area, the premotor cortex, the thalamus, the putamen, and red nucleus, while in the CTS event-related model, changes were limited to blood-oxygen-level-dependent (BOLD) signal increases in the sensory-motor cortices. A linear relationship was observed between the CTS density Vaudano et al. Hemodynamic Effects of CTS Density hemodynamic changes and both disease duration (positive correlation) and age (negative correlation) within the language network and the bilateral insular cortices. Our results strongly support the critical role of the CTS frequency, even during wakefulness, to interfere with the normal functioning of language brain networks.

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Cognition in patients with benign epilepsy with centrotemporal spikes: A study with long-term VEEG and RS-fMRI

Cited by 17 publications

References 44 publications

The relationship between neuromagnetic activity and cognitive function in benign childhood epilepsy with centrotemporal spikes

The relationship between neuromagnetic activity and cognitive function in benign childhood epilepsy with centrotemporal spikes

The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes

Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes

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