Cognition-Associated Protein Structural Changes in a Rat Model of Aging are Related to Reduced Refolding Capacity
Haley E. Tarbox,
Audrey Branch,
Stephen D. Fried
Abstract:Cognitive decline during aging represents a major societal burden, causing both personal and economic hardship in an increasingly aging population. There are a few well-known proteins that can misfold and aggregate in an age-dependent manner, such as amyloid β and α-synuclein. However, many studies have found that the proteostasis network, which functions to keep proteins properly folded, is impaired with age, suggesting that there may be many more proteins that incur structural alterations with age. Here, we … Show more
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