Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica

Mishra, Priya; Mittal, Amit; Rajput, Satyendra K.; Sinha, Jitendra Kumar

doi:10.1016/j.jep.2020.113509

Cited by 32 publications

(25 citation statements)

References 95 publications

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“…Various researchers are working on pharmacotherapy and many other therapeutic approaches that can aid in the treatment of epilepsy. Complementary alternative medicines like Cicuta virosa [ 59 ] and Nux vomica [ 9 ] could be used in combination with lower doses of effective drugs for better results. Such newer combinations of drugs need more research to be done to find their efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…Functional Category One crucial feature of epilepsy is cognitive dysfunction. Deregulation of cognitive dysfunction is linked to activity-dependent transcription, which is essential for the transition of neuronal plasticity to long-term from short-term [9]. Therefore, it has been put forward that long-term memory formation, which necessitates activation of transcriptional programs for various processes such as learning, depends on the chromatin modifications of activated neurons [14].…”

Section: Sno Epilepsy Genesmentioning

confidence: 99%

“…Such a situation would warrant the usage of different therapeutic strategies at different levels for better results. Various natural or herbal-based drugs like Cicuta virosa and Nux vomica have been shown to be effective in reducing seizure activity and other physiological parameters in animal models of epilepsy [ 9 , 59 ]. Several animal models have supported evidence that a combination of lamotrigine and sodium valproate aids in the management of partial-onset and generalized seizures.…”

Section: Non-conventional Therapeutic Strategiesmentioning

confidence: 99%

“…This shows the urgent need to develop appropriate therapeutic strategies to tackle the complex situation of epilepsy. Devising better treatment paradigms for epilepsy using various pharmaceutical and therapeutic approaches would need a better understanding of the different clinical and experimental strategies for the development and discovery of more efficient treatment methods that can help prevent and control the diseases [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy

et al. 2021

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Epilepsy affects around 50 million people across the globe and is the third most common chronic brain disorder. It is a non-communicable disease of the brain that affects people of all ages. It is accompanied by depression, anxiety, and substantially increased morbidity and mortality. A large number of third-generation anti-epileptic drugs are available, but they have multiple side-effects causing a decline in the quality of life. The inheritance and etiology of epilepsy are complex with multiple underlying genetic and epigenetic mechanisms. Different neurotransmitters play intricate functions to maintain the normal physiology of various neurons. If there is any dysregulation of neurotransmission due to aberrant transmitter levels or their receptor biology, it can result in seizures. In this review, we have discussed the roles played by various neurotransmitters and their receptors in the pathophysiology of epilepsy. Drug-resistant epilepsy (DRE) has remained one of the forefront areas of epilepsy research for a long time. Understanding the mechanisms underlying DRE is of utmost importance because of its high incidence rate among epilepsy patients and increased risks of psychosocial problems and premature death. Here we have enumerated various hypotheses of DRE. Further, we have discussed different non-conventional therapeutic strategies, including combination therapy and non-drug treatment. The recent studies supporting the modern approaches for the treatment of epilepsy have been deliberated with particular reference to the mTOR pathway, breakdown of the blood-brain barrier, and inflammatory pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Sno Epilepsy Genesmentioning

confidence: 99%

Section: Non-conventional Therapeutic Strategiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy

et al. 2021

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“…In a study, N. vomica and L. trigonocephalus reduced depression, anxiety, and insomnia in climacteric women [ 14 ]. The administration of N. vomica 30CH improves the quality and quantity of sleep in individuals with a history of coffee-induced insomnia [ 15 ], it was also demonstrated that N. vomica (6CH, 12CH, and 30CH), significantly attenuates cognitive impairment and anxiety, in mice that exhibited its anxiolytic potential [ 16 ]. N. vomica contains strychnine, in this regard it was found that neurons in the lateral/basolateral amygdala express functional strychnine-sensitive glycine receptors, thus microinjection of strychnine directly into the basolateral amygdala reduces anxiety-like behavior in rats [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Individualized Homeopathy in Treatment-Resistant Depression

Zepeda-Quiroz

Luna-Reséndiz

Soto‐Sanchez

2021

Cureus

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Investigation of the mechanism of nephrotoxicity of nux‐vomica by PTGS2/CYP2C9‐mediated arachidonic acid pathway and Jian Pi Tong Luo compound's protective effect

Zhang,

An,

Zhao

et al. 2024

Biomedical Chromatography

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The clinical effectiveness of nux‐vomica in treating rheumatism and arthralgia is noteworthy; however, its nephrotoxicity has sparked global concerns. Hence, there is value in conducting studies on detoxification methods based on traditional Chinese medicine compatibility theory. Blood biochemistry, enzyme‐linked immunosorbent assay, and pathological sections were used to evaluate both the nephrotoxicity of nux‐vomica and the efficacy of the Jian Pi Tong Luo (JPTL) compound in mitigating this toxicity. Kidney metabolomics, using ultra‐high‐performance liquid chromatography–quadrupole‐time‐of‐flight–MS (UPLC–Q‐TOF–MS), was applied to elucidate the alterations in small‐molecule metabolites in vivo. In addition, network pharmacology analysis was used to verify the mechanism and pathways underlying the nephrotoxicity associated with nux‐vomica. Finally, essential targets were validated through molecular docking and western blotting. The findings indicated significant nephrotoxicity associated with nux‐vomica, while the JPTL compound demonstrated the ability to alleviate this toxicity. The mechanism potentially involves nux‐vomica activating the “PTGS2/CYP2C9–phosphatidylcholine–arachidonic acid metabolic pathway.” This study establishes a scientific foundation for the clinical use of nux‐vomica and lays groundwork for further research and safety assessment of toxic Chinese herbal medicines.

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Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica

Cited by 32 publications

References 95 publications

Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy

Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy

Efficacy of Individualized Homeopathy in Treatment-Resistant Depression

Investigation of the mechanism of nephrotoxicity of nux‐vomica by PTGS2/CYP2C9‐mediated arachidonic acid pathway and Jian Pi Tong Luo compound's protective effect

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