Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine

SIMONEAUROY, J; Marti, Sebastien; Deal, Cheri; Huot, Céline; Robaey, Philippe; VANVLIET, G

doi:10.1016/s0022-3476(04)00142-8

Cited by 24 publications

(38 citation statements)

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“…These results have been reported previously [2] and are used here only to test their association with ERP variables.…”

Section: Methodsmentioning

confidence: 56%

“…All subjects were born between December 1989 and December 1994, and were 5.8 ± 0.1 years old at the time of evaluation. The intellectual and behavioural outcomes of these children have been described previously [2]. The criterion for severity of CH was the area of the knee epiphyses at diagnosis: severe CH: <0.05 cm 2 (n = 2 boys, 6 girls); moderate CH: >0.05 cm 2 (n = 2 boys, 5 girls).…”

Section: Methodsmentioning

confidence: 99%

“…High-dose (10–15 µg/kg·day) levothyroxine (LT 4 ) given very early after birth has effectively normalised global psychomotor development in our longitudinal cohort of children with congenital hypothyroidism (CH) at 18 months [1] and 5 years 9 months [2]. However, differences on subscales remain and are attributed both to the severity of the disease and to treatment-related factors [2, 3].…”

Section: Introductionmentioning

confidence: 99%

“…However, differences on subscales remain and are attributed both to the severity of the disease and to treatment-related factors [2, 3]. This paper aimed at testing the effects of early high-dose LT 4 treatment on auditory brain event-related potentials (ERPs) at 5 years 9 months, before entry in the elementary school.…”

Section: Introductionmentioning

confidence: 99%

“…(b) Shortly after birth, the baby no longer benefits from maternal T 4 and plasma T 4 levels at diagnosis mostly reflect the residual thyroid function of the newborn. The earliest possible treatment (before 14 days) is crucial [1, 2, 6, 7]. (c) Treatment with high-dose LT 4 then quickly normalises plasma thyrotropin or thyroid-stimulating hormone (TSH) but induces high plasma T 4 levels [8].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Early High-Dose Levothyroxine Treatment on Auditory Brain Event-Related Potentials at School Entry in Children with Congenital Hypothyroidism

Marti¹,

Álvarez

Simoneau-Roy

et al. 2006

Horm Res Paediatr

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Aims: We tested whether brain event-related potentials (ERPs) are normal in children with congenital hypothyroidism (CH) after early high-dose levothyroxine treatment. Methods: Auditory ERPs were recorded in 33 normal controls and in 15 children with CH at 5 years 9/12. Based on bone maturation at diagnosis, the CH group was divided into severe (n = 8) and moderate (n = 7) subgroups. CH patients were treated at a median age of 14 days with a mean initial dose of levothyroxine of 11.6 µg/kg·day. Two ERP components (N100 and N200) were measured and clinical follow-up variables collected. Results: The functional anatomical and cognitive organisation of the auditory system, as revealed by the analyses of ERP measures, did not differ between CH and controls, or between severe and moderate CH subjects. However, N200 latency was globally longer in the CH than in the control group (p = 0.01) and was positively correlated with the over-treatment index (r = 0.61; p < 0.05) and verbal IQ. N200 amplitude was negatively correlated with initial dose (r = –0.74; p < 0.005). Conclusion: These data suggest that sensitive tools such as ERPs can reveal differences between CH and controls and relate these differences to the adequacy of treatment of CH.

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“…These results have been reported previously [2] and are used here only to test their association with ERP variables.…”

Section: Methodsmentioning

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Early High-Dose Levothyroxine Treatment on Auditory Brain Event-Related Potentials at School Entry in Children with Congenital Hypothyroidism

Marti¹,

Álvarez

Simoneau-Roy

et al. 2006

Horm Res Paediatr

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Levothyroxine in Children

Brenta

2021

70 Years of Levothyroxine

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Thyroid hormones are essential for the development of the central nervous system early in life. Congenital hypothyroidism once caused the devastating cognitive and physical deficits of cretinism, but this condition is now detected routinely at birth using population-wide neonatal screening in most countries. Early and continuous treatment of these children with levothyroxine (LT4), according to age-specific reference ranges, ensures near-normal neuropsychological development, with preserved IQ, although the possibility of subtle residual effects on some indices of neuropsychological functioning remain an active area of research. Children who develop overt hypothyroidism also require treatment with LT4. Most children diagnosed with subclinical hypothyroidism are unlikely to require intervention with LT4, as this condition reverses spontaneously over time. These children should be monitored for possible deterioration of thyroid function in future, especially where thyroid autoimmunity is present.

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Influence of Timing and Dose of Thyroid Hormone Replacement on Mental, Psychomotor, and Behavioral Development in Children with Congenital Hypothyroidism

Bongers-Schokking

Keizer‐Schrama

2005

The Journal of Pediatrics

120

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Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine

Abstract: Children with severe CH treated early with a high dose of levothyroxine have normal global development and behavior at school entry.

Cited by 24 publications

References 0 publications

Effects of Early High-Dose Levothyroxine Treatment on Auditory Brain Event-Related Potentials at School Entry in Children with Congenital Hypothyroidism

Effects of Early High-Dose Levothyroxine Treatment on Auditory Brain Event-Related Potentials at School Entry in Children with Congenital Hypothyroidism

Levothyroxine in Children

Influence of Timing and Dose of Thyroid Hormone Replacement on Mental, Psychomotor, and Behavioral Development in Children with Congenital Hypothyroidism

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