Cogan syndrome: Characteristics, outcome and treatment in a French nationwide retrospective study and literature review

Durtette, Charlotte; Hachulla, É.; Resche‐Rigon, Matthieu; Papo, Thomas; Zénone, Thierry; Lioger, Bertrand; Deligny, C.; Lambert, Marc; Landron, C.; Pouchot, J.; Kahn, Jean‐Emmanuel; Lavigne, Christian; Wazières, B. de; Dhôte, Robin; Gondran, G.; Pertuiset, Édouard; Quéméneur, T.; Hamidou, M.; Sève, P.; Gallou, Thomas Le; Grasland, A.; Hatron, Pierre‐Yves; Fain, Olivier; Mékinian, A.

doi:10.1016/j.autrev.2017.10.005

Cited by 54 publications

(24 citation statements)

References 18 publications

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“…In all cases but one, the treatment was able to lead to some improvement or stabilization of hearing loss and corticosteroid tapering. Durtette et al confirmed that patients receiving infliximab experienced significant improvement in vestibuloauditory signs, different from patients with steroids alone or DMARDs, while systemic and ocular signs usually improve with steroids alone [ 75 ]. However, complete remission is rarely reported.…”

Section: Audiovestibular Pathology Associated With Systemic Autoimmentioning

confidence: 99%

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

Girasoli

Cazzador

Padoan

et al. 2018

Journal of Immunology Research

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The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. The association of vertigo and autoimmune diseases has been largely documented, suggesting that autoimmune disorders could be overrepresented in patients with vertigo in comparison to the general population. The aim of this review is to present the recent literature findings in the field of autoimmune-mediated diseases with cochleovestibular involvement, focusing on the clinical presentation, diagnosis, and treatment of immune-mediated inner ear diseases including autoimmune inner ear disease (AIED), Meniere's disease, and bilateral vestibulopathy, as well as of systemic autoimmune diseases with audiovestibular disorders, namely, Behçet's disease, Cogan's syndrome, sarcoidosis, autoimmune thyroid disease, Vogt-Koyanagi-Harada syndrome, relapsing polychondritis, systemic lupus erythematosus, antiphospholipid syndrome, IgG4-related disease, and ANCA-associated vasculitides.

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Section: Audiovestibular Pathology Associated With Systemic Autoimmentioning

confidence: 99%

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

Girasoli

Cazzador

Padoan

et al. 2018

Journal of Immunology Research

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“…In Cogan's syndrome, infliximab was identified as a promising therapy, enabling steroid tapering and improving vestibular-auditory outcomes. (4) Because of the high risk of recurrence, maintenance therapy appears reasonable in aseptic abscesses as well, and efficacy of tumor necrosis factorα inhibitors, azathioprine, and sulfasalazine has been reported. (1) Thus, we started infliximab and azathioprine as a maintenance therapy in the reported case.…”

Section: Discussionmentioning

confidence: 99%

Aseptic Liver Abscesses as an Exceptional Finding in Cogan’s Syndrome

et al. 2021

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A septic abscesses of deep organs are very rare, and their pathogenesis is unclear. Most reported cases affect spleen or liver and are associated with inflammatory bowel disease, Behҫet's disease, and/or other cutaneous or arthritic manifestations. (1,2) Here, we report a case of aseptic liver abscesses diagnosed in a patient with Cogan's syndrome, a rheumatic disease primarily affecting the inner ears and eyes. Case PresentationA 41-year-old Caucasian woman presented with fever (39.1°C), abdominal pain, and unintended weight loss. Alongside, the patient reported a progressive hearing loss for 1 year and several episodes of eye redness. She was on no regular medications and there were no known allergies.Initially, the patient was treated with piperacillin/ tazobactam and metronidazole. As fever continued and Abbreviations: CT, computed tomography; FDG-PET, fluorodeoxyglucose-positron emission tomography.

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“…Systemic corticotherapy associated with disease-modifying antirheumatic drugs and TNF inhibitors currently represents the main treatment of CS. Infliximab showed superior effects in vestibuloauditory outcomes in a retrospective study [6].…”

Section: Discussionmentioning

confidence: 99%

Nail Lichen Planus in a Patient with Cogan Syndrome: Report of a Case and Discussion

Houriet

Haneke

2019

Case Rep Dermatol

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Cogan syndrome and lichen planus represent two autoimmune disorders. Cogan syndrome is a very rare type of ANCA-negative vasculitis affecting the eyes and vestibulocochlear system. It has been associated with other autoimmune disorders, none of them showing any lichenoid inflammation. We herein report the first case of a patient that suffered from Cogan disease and developed isolated lichen planus on all nails a few years after the first diagnosis. The combination of two autoimmune disorders is not unusual and raises the question of common immunogenetic pathomechanisms.

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Cogan syndrome: Characteristics, outcome and treatment in a French nationwide retrospective study and literature review

Cited by 54 publications

References 18 publications

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

Aseptic Liver Abscesses as an Exceptional Finding in Cogan’s Syndrome

Nail Lichen Planus in a Patient with Cogan Syndrome: Report of a Case and Discussion

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