Cofitness network connectivity determines a fuzzy essential zone in open bacterial pangenome
Pan Zhang,
Biliang Zhang,
Yuan‐Yuan Ji
et al.
Abstract:Most in silico evolutionary studies commonly assumed that core genes are essential for cellular function, while accessory genes are dispensable, particularly in nutrient‐rich environments. However, this assumption is seldom tested genetically within the pangenome context. In this study, we conducted a robust pangenomic Tn‐seq analysis of fitness genes in a nutrient‐rich medium for Sinorhizobium strains with a canonical open pangenome. To evaluate the robustness of fitness category assignment, Tn‐seq data for t… Show more
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