Cofilin-1 signaling mediates epithelial-mesenchymal transition by promoting actin cytoskeleton reorganization and cell-cell adhesion regulation in colorectal cancer cells

Sousa-Squiavinato, Annie Cristhine Moraes; Rocha, Murilo Ramos; Barcellos-de-Souza, Pedro; Souza, Waldemir Fernandes de; Morgado‐Díaz, José Andrés

doi:10.1016/j.bbamcr.2018.10.003

Cited by 70 publications

(56 citation statements)

References 38 publications

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“…Among mutp53-driven hyper-secreted proteins, we identified cofilin (COF1), which is involved in tumor cell migration and invasion by promoting actin cytoskeleton reorganization and cell-cell adhesion regulation and the level of cofilin-1 in patient’s sera is associated with PDAC progression and poor prognosis [ 41 , 42 , 43 ]; calsyntenin-1 (CLSTN1), which plays a fundamental role in cellular adhesion and cell communication and its expression level was increased in sera of patients with lung adenocarcinoma or in ovarian adenocarcinoma cell lines, but the molecular mechanisms of CLSTN1 in cancer still need to be investigated [ 44 , 45 , 46 ]; vimentin (VIME), which is a well-known marker for epithelial-mesenchymal transition (EMT), and elevated levels of circulating vimentin were detected in hepatocellular carcinoma and in circulating tumor cells (CTCs) in PDAC. Notably, the presence of vimentin + CTCs was negatively associated with progression-free survival [ 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells

et al. 2020

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The cancer secretome is a rich repository of useful information for both cancer biology and clinical oncology. A better understanding of cancer secretome is particularly relevant for pancreatic ductal adenocarcinoma (PDAC), whose extremely high mortality rate is mainly due to early metastasis, resistance to conventional treatments, lack of recognizable symptoms, and assays for early detection. TP53 gene is a master transcriptional regulator controlling several key cellular pathways and it is mutated in ~75% of PDACs. We report the functional effect of the hot-spot p53 mutant isoforms R175H and R273H on cancer cell secretome, showing their influence on proliferation, chemoresistance, apoptosis, and autophagy, as well as cell migration and epithelial-mesenchymal transition. We compared the secretome of p53-null AsPC-1 PDAC cells after ectopic over-expression of R175H-mutp53 or R273H-mutp53 to identify the differentially secreted proteins by mutant p53. By using high-resolution SWATH-MS technology, we found a great number of differentially secreted proteins by the two p53 mutants, 15 of which are common to both mutants. Most of these secreted proteins are reported to promote cancer progression and epithelial-mesenchymal transition and might constitute a biomarker secreted signature that is driven by the hot-spot p53 mutants in PDAC.

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Section: Discussionmentioning

confidence: 99%

The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells

et al. 2020

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“…PI3K-Akt signaling pathway plays an important role in tumorigenesis and regulates critical cellular functions including survival, proliferation and metabolism [49]. Regulation of actin cytoskeleton is an essential step in cell migration during activation of the epithelialmesenchymal transition program, which is associated with metastatic properties of cancer cells [50]. And Rap1 signaling pathway has also been reported to be involved in tumorigenesis and tumor progression [51].…”

Section: Discussionmentioning

confidence: 99%

Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion

et al. 2018

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Malignant pleural effusion (MPE) is a common complication of lung cancer. Accumulating evidence has suggested that circular RNAs (circRNAs) play important roles in oncogenesis and progression of cancer. However, the expression pattern of circRNAs in MPE remains largely unknown and awaits investigation. The study was designed to elucidate the potential roles of differentially expressed circRNAs in MPE. Herein, we detected a total of 1350 differentially expressed circRNAs and 1727 differentially expressed mRNAs in lung adenocarcinoma-associated malignant pleural effusion (LA-MPE) compared with tuberculous pleural effusion (TPE) by Clariom D Human Microarray. Among the top 5 up-regulated circRNAs (hsa_circ_0067705, hsa_circ_0025542, hsa_circ_0072793, hsa_-circ_0084927, and hsa_circ_0085386), four were verified significantly up-regulated in LA-MPE by qRT-PCR and hsa_circ_0085386 had an increasing trend. CircRNA-miRNA-mRNA network for the top 5 upregulated circRNAs was constructed and pathway analysis indicated that the enriched mRNA targets involved in PI3K-Akt signaling pathway, Axon guidance, Regulation of actin cytoskeleton and Rap1 signaling pathway were potentially regulated by these aberrantly expressed circRNAs. We generated specific circRNA profiles in LA-MPE for the first time. And analysis of circRNA regulatory network could provide evidence that circRNAs are important in MPE development because they participate in cancer-related pathways by sequestering miRNAs. Our findings suggested that aberrantly expressed circRNAs may be involved in the development of LA-MPE. ARTICLE HISTORY

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“…The EMT is suggested to be the rst step in the metastatic of cancer cells by emerging evidence. Loss or reduction of E-cadherin expression is considered to be the primary and most important step in the EMT process, and EMT is a critical step in cancer metastasis [39,40] .…”

Section: Discussionmentioning

confidence: 99%

Variation rs9929218 and Risk of the Colorectal Cancer and Adenomas: A Meta-analysis

Wang

Gu²,

et al. 2020

Preprint

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Backgrounds: Genome-wide association studies (GWAS) have identiﬁed multiple common CRC-related (colorectal cancer) SNPs (single nucleotide polymorphisms) including the Cadherin 1(CDH1) rs9929218 may act by increasing the risk of colorectal cancer, colorectal adenoma, or both. These studies, however, reported inconsistent associations. Methods: To derive a more accurate approximation of the connection, we carried out a meta-analysis of 12 published pieces of research including 11,590 controls and 8,192 cases. We used odds ratios (ORs) and 95% conﬁdence intervals (CIs) to evaluate the associations' strength.Results: Meta-analysis implied considerable association between CRC and rs9929218 (OR = 1.21, 95%CI 1.04-1.42 for GG versus AA; OR = 1.22, 95%CI 1.05-1.42 for GG/AG versus AA).In the subgroup analyses, significantly increased risks were found among Europeans.Conclusions: In summary, our meta-analysis studies in different populations confirmed that SNP rs9929218 is significantly associated with CRC risk and that this variant may have a greater impact on Europeans.

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Cofilin-1 signaling mediates epithelial-mesenchymal transition by promoting actin cytoskeleton reorganization and cell-cell adhesion regulation in colorectal cancer cells

Cited by 70 publications

References 38 publications

The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells

The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells

Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion

Variation rs9929218 and Risk of the Colorectal Cancer and Adenomas: A Meta-analysis

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