2022
DOI: 10.17219/acem/152032
|View full text |Cite
|
Sign up to set email alerts
|

Cofilin-1 and profilin-1 expression in lung microvascular endothelial cells exposed to titanium dioxide nanoparticles

Abstract: and profilin-1 expression in lung microvascular endothelial cells exposed to titanium dioxide nanoparticles [published online as ahead of print on August 24, 2022].

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 43 publications
0
2
0
Order By: Relevance
“…These findings identified cofilin2 phosphorylation and F-actin disassembly as novel downstream effectors of DNA-PKcs activation in endotoxemia-induced endothelial injury, thus elucidating the molecular basis by which LPS promotes endothelial cytoskeleton degradation. Most previous studies focused on the impact of cofilin1 phosphorylation on endothelial dysfunction during physiopathological and toxicological conditions [ 55 57 ]. Cofilin1 is mainly expressed in nonmuscle tissue, while cofilin2 is abundant in muscle [ 58 ].…”
Section: Discussionmentioning
confidence: 99%
“…These findings identified cofilin2 phosphorylation and F-actin disassembly as novel downstream effectors of DNA-PKcs activation in endotoxemia-induced endothelial injury, thus elucidating the molecular basis by which LPS promotes endothelial cytoskeleton degradation. Most previous studies focused on the impact of cofilin1 phosphorylation on endothelial dysfunction during physiopathological and toxicological conditions [ 55 57 ]. Cofilin1 is mainly expressed in nonmuscle tissue, while cofilin2 is abundant in muscle [ 58 ].…”
Section: Discussionmentioning
confidence: 99%
“…Our previous studies showed that a long-term (for 1 and 3 months) intragastric intake of nano-TiО 2 by rats leads to its selective accumulation in tissues and organs, and is accompanied by changes in the motility of visceral SMs (Tsymbalyuk et al, 2017;Tsymbalyuk et al, 2019;An et al, 2022) Since nanoparticles are known to enter the tissues of the digestive tract wall and partially accumulate there, studying the state of the pacemaker mechanisms of regulation of smooth muscle spontaneous contractions in the stomach and large intestine under chronic exposure to TiО 2 nanoparticles is relevant and interesting. Thus the aim of this research work was to study the spontaneous contractile activity of the gastric and large intestine SMs of rats under chronic (for 6 months) intake of an aqueous suspension of TiО 2 nanoparticles.…”
Section: Introductionmentioning
confidence: 99%