The purpose of this study is to investigate the difficulties faced by female business owners in the Bule Hora town administration in Ethiopia's Horn of Africa. Due to problems with how women are regarded, treated, and considered to be, there is a difference between women who are inactive and those who have potential. The researchers used a qualitative research design and an interpretative research technique. The researchers spoke with eight female business owners who were engaged in the company's founding. The purposive sample strategy was used to gather primary data from the respondent using a structured interview. For the analysis of qualitative data, thematic data analysis was used. The primary conclusions of the study showed that social and cultural barriers, lack of money, a lack of adequate employment prospects, a lack of expertise, and lack of training were the biggest challenges for women entrepreneurs in the study area. The study's conclusions will help the government as it updates its policies to address organisational, individual, legal/administrative, economic, social/cultural, and other aspects that affect how women entrepreneurs view entrepreneurship.