Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents

Abstract

Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector's sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material.

Coffee Silverskin: A Review on Potential Cosmetic Applications

“…On the other hand, the tested concentrations of CS extracts were not cytotoxic, and a CS extract of 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. According to the authors, the anti-aging properties of CS may be due to its complex mixture of antioxidants that act in a synergistic combination [33]. In sum, CS extracts have the potential to be used as an ingredient in skin cosmetic product to reduce the production of intracellular ROS in keratinocytes and improving skin health.…”

“…A new approach on anti-aging effect of CS extracts against accelerated aging caused by oxidative agents, was performed by Iriondo-DeHond et al [33]. In this study, accelerated aging in C. elegans (animal model) was induced by ultraviolet radiation C (UVC) and in HaCaT cells (skin model) using tert-butyl hydroperoxide (t-BOOH).…”

Formulation and Stability Assessment of Arabica and Civet Coffee Extracts Based Cosmetic Preparations

“…The results suggested that coffee silverskin extract protects the human keratinocytes from oxidative damages and extends the lifespan of Caenorhabditis elegans [19]. Rodrigues et al [20] proved that coffee silverskin was a cosmetically significant candidate with high antioxidant and antimicrobial property with no cytotoxicity to human cells.…”

Licorice extract attenuates brain aging of d-galactose induced rats through inhibition of oxidative stress and attenuation of neuronal apoptosis

“…While ROS are excessively generated and exceed the ability of organism anti-oxidation the body will be in oxidative stress, which leads to a sharp deterioration of many bodily functions such as a gradual deterioration in learning and memory capacity and acceleration of apoptosis levels in the brain. 36 There are numerous endogenous antioxidants (SOD, GSH-Px, and CAT) that constitute the body's own natural defense systems and keep a certain balance with ROS to limit free radical damage in neuronal tissues. 37 The oxidative stress damage increases in aging, mainly because of anti-oxidation deciency.…”