Coffee reduces the risk of hepatocellular carcinoma probably through inhibition of NLRP3 inflammasome activation by caffeine

Fan, Frank S.

doi:10.3389/fonc.2022.1029491

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…Conversely, it is important to note that both coffee and caffeic acid, a bioactive compound found in various herbs, vegetables, and fruits, hold promising anticancer potential. As an example, coffee consumption has been associated with a reduced risk of hepatocellular carcinoma [ 13 ]. Similarly, caffeic acid exhibits antitumor actions by exerting pro-oxidant and antioxidant properties, inhibiting reactive oxygen species formation, and suppressing angiogenesis and matrix metalloproteinases, suggesting its therapeutic implications for cancer treatment and prevention [ 14 ].…”

Section: Influence Of Dietary Factors On Bladder Cancer Riskmentioning

confidence: 99%

Unraveling the Dietary Puzzle: Exploring the Influence of Diet, Nutraceuticals, and Supplements on Bladder Cancer Risk, Outcomes, and Immunotherapy Efficacy: Insights from the BLOSSOM Study and Beyond

Buonerba,

Ingenito,

Di Trolio

et al. 2024

Oncol Ther

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Bladder cancer is considered a global health concern characterized by significant morbidity and mortality rates. The complex relationship between diet and bladder cancer is examined, with a specific focus on the role of diet in risk, outcomes, and treatment efficacy. Attention is drawn to the burgeoning field of immunotherapy in bladder cancer treatment, and the possible influence of diet on its outcomes is explored. While evidence remains limited, prior studies in other cancer types have suggested a potential connection between diet and immunotherapy response. To address this knowledge gap, the ongoing BLOSSOM study is presented, which aims to investigate the link between dietary factors, lifestyle, and the effectiveness of immunotherapy in patients with non-muscle-invasive bladder cancer. Ongoing efforts to decipher the intricate relationship between diet and bladder cancer care are highlighted, emphasizing the quest to unravel the dietary puzzle for the improvement of bladder cancer management.

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Section: Influence Of Dietary Factors On Bladder Cancer Riskmentioning

confidence: 99%

Unraveling the Dietary Puzzle: Exploring the Influence of Diet, Nutraceuticals, and Supplements on Bladder Cancer Risk, Outcomes, and Immunotherapy Efficacy: Insights from the BLOSSOM Study and Beyond

Buonerba,

Ingenito,

Di Trolio

et al. 2024

Oncol Ther

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“…Espresso coffee is among the best known beverages worldwide, and drinking espresso has become a habit in many countries due to its pleasant taste. For many years, coffee consumption was associated with health risks; however, recent studies showed that when consumed in moderation, this soft drink could have beneficial effects on human health thanks to its biological properties. , The analysis and review of observational studies present in the literature suggest that consuming coffee could be advantageous against a number of chronic diseases, including some cancers (liver, colorectal, endometrial, and prostate), metabolic diseases (type-2 diabetes and metabolic syndrome), and neurological disorders (Parkinson′s disease, Alzheimer′s disease, and depression) . In particular, numerous studies report that moderate and, sometimes, even high coffee consumption exerts a neuroprotective action against two of the most common neurodegenerative diseases, i.e., Parkinson′s and Alzheimer′s. − Many coffee compounds display beneficial properties in alleviating disease symptoms, for instance by reducing cognitive and memory impairment, as antioxidants, or by preventing amyloid formation and neurotoxicity .…”

Section: Introductionmentioning

confidence: 99%

Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer′s Associated Tau Protein

Tira

Viola

Barracchia

et al. 2023

J. Agric. Food Chem.

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Espresso coffee is among the most consumed beverages in the world. Recent studies report a protective activity of the coffee beverage against neurodegenerative disorders such as Alzheimer′s disease. Alzheimer′s disease belongs to a group of disorders, called tauopathies, which are characterized by the intraneuronal accumulation of the microtubule-associated protein tau in fibrillar aggregates. In this work, we characterized by NMR the molecular composition of the espresso coffee extract and identified its main components. We then demonstrated with in vitro and in cell experiments that the whole coffee extract, caffeine, and genistein have biological properties in preventing aggregation, condensation, and seeding activity of the repeat region of tau. We also identified a set of coffee compounds capable of binding to preformed tau fibrils. These results add insights into the neuroprotective potential of espresso coffee and suggest candidate molecular scaffolds for designing therapies targeting monomeric or fibrillized forms of tau.

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Breaking Down the Arsenal: Recent Progress in the Nanotherapeutic Strategies for Hepatocellular Carcinoma Treatment

Roy,

Harish,

Mohd

et al. 2024

Advanced Therapeutics

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Hepatocellular carcinoma (HCC) is a progressed form of advanced liver cancer and is one of the major causes of global cancer burden. The primary causes for high HCC mortality is the delayed diagnosis of the diseaseas early stage HCC is typically asymptomatic and patients frequently overlook the warning signs. Currently, the most efficacious single‐drug therapy approved by the food and drug administration (FDA) for HCC is Sorafenib and Nivolumab as a second‐line therapy for late stage HCC. Nowadays nanotechnology is used to deliver either a diagnostic tool for biomolecular imaging ortherapeutic agent. Gene therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)‐CRISPR associated protein 9 (CRISPR‐Cas9) are currently studied to find a potential curative option for HCC. Natural products from plants are being extensively extracted and isolated as they may offer a promising alternative in order to control and treat HCC. They exhibit anti‐HCC effects by stimulating the immune system and by hindering various growth pathways involved in cancer development and progression. In this review article, an overview is provided on the current global incidence, ongoing systemic treatment strategies, and recent advances in nanomedicine for the management of HCC and also ongoing efforts to overcome these challenges.

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Coffee reduces the risk of hepatocellular carcinoma probably through inhibition of NLRP3 inflammasome activation by caffeine

Abstract: Fan FS (2022) Coffee reduces the risk of hepatocellular carcinoma probably through inhibition of NLRP3 inflammasome activation by caffeine.

Cited by 5 publications

References 52 publications

Unraveling the Dietary Puzzle: Exploring the Influence of Diet, Nutraceuticals, and Supplements on Bladder Cancer Risk, Outcomes, and Immunotherapy Efficacy: Insights from the BLOSSOM Study and Beyond

Unraveling the Dietary Puzzle: Exploring the Influence of Diet, Nutraceuticals, and Supplements on Bladder Cancer Risk, Outcomes, and Immunotherapy Efficacy: Insights from the BLOSSOM Study and Beyond

Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer′s Associated Tau Protein

Breaking Down the Arsenal: Recent Progress in the Nanotherapeutic Strategies for Hepatocellular Carcinoma Treatment

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