Coffee prevents IQ-induced liver damage by regulating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and the MAPK/NF-κB signaling pathway in zebrafish

Comparison of the hepatoprotection of intragastric and intravenous cyanidin-3-glucoside administration: focus on the key metabolites and gut microbiota modulation

“…Moreover, TUNEL staining was performed to visualize cell apoptosis, in which blue or green fluorescence represents cell nuclei or fragmented DNA, respectively. 18 As shown in Fig. 2B, few TUNEL-positive cells were observed in the liver tissue of the NC group, whereas the MC group exhibited a noticeable increase in green fluorescence.…”

Evaluating the Neuroprotective Potential of Caffeinated Coffee in the Context of Aluminum-Induced Neurotoxicity: Insights from a PC12 Cell Culture Model

“…Its activation increases along with the activation of MAPK (Al activates MAPK, as it was already mentioned in this paragraph) and leads to an elevation in the production of pro-inflammatory factors, potentially causing cell damage [ 78 ]. As indicated by the latest research, CGA inhibits NF-κB by suppressing p38 MAPK activation, contributing to the prevention of cell death [ 79 , 80 , 81 ]. It can be concluded that constituents of caffeinated coffee, likely primarily CGA, mitigate the neurotoxicity of Al and thus reduce the risk of neurodegenerative diseases development.…”

“…Figure 3. Effect of caffeine(5,80, and 320 µg/mL), coffee (caffeine concentration of 5, 80, and 320 µg/mL), aluminum maltolate (50 µM and 100 µM), and H 2 0 2 (200 µM) on the viability of PC12 cells after 24 h incubation in comparison to the control cells without additives. The results are presented as mean ± standard deviation (SD) (indicated as the upper edge of the column and whiskers, respectively) of three independent experiments.…”