Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults

Jokura, Hiroko; Watanabe, Isamu; Umeda, Mika; Hase, Tadashi; Shimotoyodome, Akira

doi:10.1016/j.nutres.2015.07.005

Cited by 58 publications

(43 citation statements)

References 37 publications

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“…Numerous biological and pharmacological properties of this compound, such as antiinflammatory (JOYEUX et al, 1995), anticancerogenic (CHALLIS and BARTLETT, 1975), antiviral (FRANK et al, 1989) and ability to completely block the production of reactive oxygen species (ROS) (SUDINA et al, 1993) have been discovered. In addition, the daily consumption of coffee lowers the risk of cardiovascular diseases and diabetes (JOKURA et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic features of caffeic acid: Theoretical study

Tošović¹

2017

Kragujevac J Sci

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ABSTRACT. In order to investigate spectroscopic features of caffeic acid (CA), the IR, Raman, 13 C-NMR, 1 H-NMR, and UV spectra of this compound were simulated. For this purpose the B3LYP-D3/6-311+G(d,p) theoretical model was used in combination with CPCM solvation model. Very good agreement between all experimental and simulated spectra was achieved. This result indicates that B3LYP-D3 can be a method of choice in studies that refer to spectroscopic investigations. Spectroscopic features of CA are very similar to those of chlorogenic acid (5-O-caffeoylquinic acid) (MARKOVIĆ, TOŠOVIĆ and DIMITRIĆ MARKOVIĆ, 2016), pointing out the significance of caffeic moiety.

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Section: Introductionmentioning

confidence: 99%

Spectroscopic features of caffeic acid: Theoretical study

Tošović¹

2017

Kragujevac J Sci

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“…Caffeic acid (3,4‐dihydroxycinnamic acid, CA) is one of the most representative hydroxycinnamic acids in the diet, being present in many foods and beverages, including coffee. More recently, many studies have demonstrated the potential health benefits of daily coffee consumption, and several epidemiological studies reported that a life‐long regular though moderate consumption of coffee lowers the risk of diabetes and cardiovascular diseases . In food, CA is mainly found as chlorogenic acid, the quinic acid conjugated form.…”

Section: Introductionmentioning

confidence: 99%

Low nanomolar caffeic acid attenuates high glucose‐induced endothelial dysfunction in primary human umbilical‐vein endothelial cells by affecting NF‐κB and Nrf2 pathways

Fratantonio

Speciale

Canali³

et al. 2016

BioFactors

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Hyperglycemia contributes to dysregulate endothelial function associated with diabetes, leading to initiation and propagation of vascular complications and dysfunction. Caffeic acid (CA), a dietary hydroxycinnamic acid abundant in coffee, has been reported to exert antidiabetic effects in rat models. Herein, we investigated the molecular effects of physiological concentrations of CA (10 nM) against endothelial dysfunction induced by high glucose (HG) in human endothelial cells (HUVECs). HUVECs were exposed to HG 25 mM, to mimic diabetic condition, in presence of CA. Intracellular redox status (reduced glutathione, superoxide dismutase (SOD) and total antioxidant activity levels), and NF-κB pathway were examined. We also evaluated the involvement of NF-E2-related factor 2 (Nrf2)/electrophile responsive element (EpRE) pathway. Our data show that CA inhibits HG-induced nuclear translocation of NF-κB and the downstream expression of endothelial adhesion molecule 1 and restores antioxidant levels by upregulating Nrf2/EpRE pathway. Our data suggest that CA can suppress several aspects of HG-induced endothelial dysfunction through the modulation of intracellular redox status controlled by the transcription factor Nrf2. These findings highlight that low physiological concentration of CA achievable specifically upon food consumption are able to prevent endothelial dysfunction associated with inflammation and oxidative stress induced by high concentration of glucose. © 2016 BioFactors, 43(1):54-62, 2017.

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“…We found three studies that examined heterogeneity in health responses to the chlorogenic acid fraction of coffee. [ 79–81 ] A recent review on the inter‐individual variability of chlorogenic acids in cardiometabolic biomarkers evaluated seven studies addressing this topic, however, they also included studies with a dietary source other than coffee, for example, artichokes. [ 106 ] Chlorogenic acids exert favorable effects on human health, as they show anti‐inflammatory, antioxidant, anti‐carcinogenic, anti‐diabetic, and anti‐atherogenic properties.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, 24 studies were related to cancer ( Table 1 ), [ 17–40 ] and 50 studies to cardiometabolic diseases ( Table 2 ). [ 41–90 ]…”

Section: Methodsmentioning

confidence: 99%

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

Visser

Geleijnse

Roos

2020

Molecular Nutrition Food Res

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Scope: Coffee is associated with a lower risk of cancer, cardiovascular disease, and type 2 diabetes at the population level. However, individual susceptibility to the effects of coffee consumption will cause heterogeneity in health responses between individuals. In this critical review determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption are systematically evaluated. Methods and results: Embase and MEDLINE are searched for observational studies and clinical trials that examined variation in the response to coffee consumption. A total of 74 studies meet the inclusion criteria, which report variation in cancer (n = 24) and cardiometabolic health (n = 50) outcomes. The qualitative analysis shows that sex, BMI, smoking, alcohol intake, menopausal status, and genetic polymorphisms are probable or possible determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption, albeit the majority of studies have insufficient statistical power to detect significant interaction between these factors and coffee consumption. Conclusion: Several genetic and non-genetic determinants of inter-individual variability in the responses to coffee and caffeine consumption are identified, indicating that some of the health benefits of coffee may only occur in a subgroup of subjects.

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Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults

Cited by 58 publications

References 37 publications

Spectroscopic features of caffeic acid: Theoretical study

Spectroscopic features of caffeic acid: Theoretical study

Low nanomolar caffeic acid attenuates high glucose‐induced endothelial dysfunction in primary human umbilical‐vein endothelial cells by affecting NF‐κB and Nrf2 pathways

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

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