Coffee consumption revealed sex differences in host endogenous metabolism and gut microbiota in healthy adults

Chong, Chun Wie; Wong, Lai Chun; Teh, Cindy Shuan Ju; Ismail, Nor Hadiani; Chan, Pei Qi; Lim, Chiu Sien; Yap, Siu Ching; Yap, Ivan Kok Seng

doi:10.1111/jfbc.13535

Cited by 10 publications

(9 citation statements)

References 55 publications

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“…Coffee has been confirmed to confer various health benefits, and drinking coffee can alter a host's gut microbiota (Chong et al, 2020). Coffee may partly depend on the modulation of gut microbiota to influence health (González et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats

Zhang

et al. 2022

Front. Microbiol.

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ObjectiveBased on our previous research, chronic paradoxical sleep deprivation (PSD) can cause depression-like behaviors and microbial changes in gut microbiota. Coffee, as the world’s most popular drink for the lack of sleep, is beneficial to health and attention and can eliminate the cognitive sequelae caused by poor sleep. The purpose of this study is to investigate the effects of coffee and decaffeinated coffee on PSD rats.Research Design and MethodsA total of 32 rats were divided into four groups: control group, PSD model group, conventional coffee group, and decaffeinated coffee group. Behavioral tests, including sucrose preference test, open field test, forced swimming test, and tail suspension test, as well as biochemical detection for inflammatory and antioxidant indexes were performed. The effects of coffee and decaffeinated coffee on the gut microbiota of PSD rats were investigated by 16S rRNA gene sequencing.ResultsCoffee and decaffeinated coffee significantly improved the depression-like behaviors. Moreover, the serum levels of interleukin-6 and tumor necrosis factor alpha were decreased in both coffee and decaffeinated coffee groups, as well as the levels of superoxide dismutase and GSH-Px were increased. Gut microbiota analysis revealed that the abundance of S24-7, Lachnospiraceae, Oscillospira, and Parabacteroides were significantly increased in PSD rats, while the abundance of Akkermansia and Klebsiella were significantly decreased. After the treatment of coffee and decaffeinated coffee, the abundance of the above gut microbiota was all restored in different degrees. Coffee had relatively more significant effects on PSD-induced depressive-like behaviors, while the difference between coffee and decaffeinated coffee was not obvious in correcting the disorder of gut microbiota.ConclusionsThese findings have shown that both coffee and decaffeinated coffee are effective for sleep deprivation-induced depression-like behaviors and the dysbiosis of gut microbiota and indicated that caffeine may be not the only key substance of coffee for regulating gut microbiota.

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Section: Discussionmentioning

confidence: 99%

The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats

Zhang

et al. 2022

Front. Microbiol.

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“…These differences may confound the association between coffee drinking and health outcomes across the world. In addition, biological differences may exist between men and women in response to caffeine consumption [51,52]. There might a potential gender difference in hemodynamic effects of coffee in the body [53].…”

Section: Cups Per Day Amentioning

confidence: 99%

Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose–response meta-analysis of cohort studies

Shahinfar

Jayedi

Khan

et al. 2021

Nutrition, Metabolism and Cardiovascular Diseases

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Aims: To evaluate the long-term consequences of coffee drinking in patients with type 2 diabetes. Data synthesis: PubMed, Scopus, and Web of Sciences were searched to November 2020 for prospective cohort studies evaluating the association of coffee drinking with risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes. Two reviewers extracted data and rated the certainty of evidence using GRADE approach. Random-effects models were used to estimate the hazard ratios (HRs) and 95% CIs. Doseeresponse associations were modeled by a onestage mixed-effects meta-analysis. Ten prospective cohort studies with 82,270 cases were included. Compared to those with no coffee consumption, the HRs for consumption of 4 cups/ d were 0.79 (95%CI: 0.72, 0.87; n Z 10 studies) for all-cause mortality, 0.60 (95%CI: 0.46, 0.79; n Z 4) for CVD mortality, 0.68 (95%CI: 0.51, 0.91; n Z 3) for coronary heart disease (CHD) mortality, 0.72 (95%CI: 0.54, 0.98; n Z 2) for CHD, and 0.77 (95%CI: 0.61, 0.98; n Z 2) for total CVD events. There was no significant association for cancer mortality and stroke. There was an inverse monotonic association between coffee drinking and all-cause and CVD mortality, and inverse linear association for CHD and total CVD events. The certainty of evidence was graded moderate for all-cause mortality, and low or very low for other outcomes. Conclusions: Drinking coffee may be inversely associated with the risk of mortality in patients with type 2 diabetes. However, more research is needed considering type of coffee, sugar and cream added to coffee, and history of CVD to present more confident results. Registry and registry number: The protocol of this systematic review was registered at Open Science Framework (https://osf.io/8uaf3, registered form: osf.io/xur76, registration

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“…In a more recent study conducted on a small number (30) of healthy volunteers, it was found that coffee administration led to alterations in the gut microbiota, although this was not significant [56].…”

Section: Studies On Humansmentioning

confidence: 89%

Coffee and Microbiota: A Narrative Review

Rosa,

Marigliano,

Mannucci

et al. 2024

CIMB

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Coffee is one of the most widely consumed beverages in the world, which has important repercussions on the health of the individual, mainly because of certain compounds it contains. Coffee consumption exerts significant influences on the entire body, including the gastrointestinal tract, where a central role is played by the gut microbiota. Dysbiosis in the gut microbiota is implicated in the occurrence of numerous diseases, and knowledge of the microbiota has proven to be of fundamental importance for the development of new therapeutic strategies. In this narrative review, we thoroughly investigated the link between coffee consumption and its effects on the gut microbiota and the ensuing consequences on human health. We have selected the most significant articles published on this very interesting link, with the aim of elucidating the latest evidence about the relationship between coffee consumption, its repercussions on the composition of the gut microbiota, and human health. Based on the various studies carried out in both humans and animal models, it has emerged that coffee consumption is associated with changes in the gut microbiota, although further research is needed to understand more about this link and the repercussions for the whole organism.

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Coffee consumption revealed sex differences in host endogenous metabolism and gut microbiota in healthy adults

Abstract: Williamson, 2017) such as chlorogenic acids which is a major source of antioxidants, and contains significant amount of polysaccharides such galactomannans and arabinogalactan (Gniechwitz,

Cited by 10 publications

References 55 publications

The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats

The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats

Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose–response meta-analysis of cohort studies

Coffee and Microbiota: A Narrative Review

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